Molecular Functions of WWOX Potentially Involved in Cancer Development
The WW domain-containing oxidoreductase gene (<i>WWOX</i>) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of <i>WWOX</i> in a chromosomal region frequently altered in human cancers has initiated multipl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/5/1051 |
| _version_ | 1827693593534398464 |
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| author | Karim Taouis Keltouma Driouch Rosette Lidereau François Lallemand |
| author_facet | Karim Taouis Keltouma Driouch Rosette Lidereau François Lallemand |
| author_sort | Karim Taouis |
| collection | DOAJ |
| description | The WW domain-containing oxidoreductase gene (<i>WWOX</i>) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of <i>WWOX</i> in a chromosomal region frequently altered in human cancers has initiated multiple current studies to establish its role in this disease. All of this work suggests that WWOX, due to its ability to interact with a large number of partners, exerts its tumor suppressive activity through a wide variety of molecular actions that are mostly cell specific. |
| first_indexed | 2024-03-10T11:46:42Z |
| format | Article |
| id | doaj.art-e570052e2bfb47e1b8f04ee931ea0126 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T11:46:42Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e570052e2bfb47e1b8f04ee931ea01262023-11-21T18:03:55ZengMDPI AGCells2073-44092021-04-01105105110.3390/cells10051051Molecular Functions of WWOX Potentially Involved in Cancer DevelopmentKarim Taouis0Keltouma Driouch1Rosette Lidereau2François Lallemand3Pharmacogenomics Unit, Department of Genetics, Institut Curie, 75005 Paris, FrancePharmacogenomics Unit, Department of Genetics, Institut Curie, 75005 Paris, FrancePharmacogenomics Unit, Department of Genetics, Institut Curie, 75005 Paris, FrancePharmacogenomics Unit, Department of Genetics, Institut Curie, 75005 Paris, FranceThe WW domain-containing oxidoreductase gene (<i>WWOX</i>) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of <i>WWOX</i> in a chromosomal region frequently altered in human cancers has initiated multiple current studies to establish its role in this disease. All of this work suggests that WWOX, due to its ability to interact with a large number of partners, exerts its tumor suppressive activity through a wide variety of molecular actions that are mostly cell specific.https://www.mdpi.com/2073-4409/10/5/1051WWOXcancersmolecular functions |
| spellingShingle | Karim Taouis Keltouma Driouch Rosette Lidereau François Lallemand Molecular Functions of WWOX Potentially Involved in Cancer Development Cells WWOX cancers molecular functions |
| title | Molecular Functions of WWOX Potentially Involved in Cancer Development |
| title_full | Molecular Functions of WWOX Potentially Involved in Cancer Development |
| title_fullStr | Molecular Functions of WWOX Potentially Involved in Cancer Development |
| title_full_unstemmed | Molecular Functions of WWOX Potentially Involved in Cancer Development |
| title_short | Molecular Functions of WWOX Potentially Involved in Cancer Development |
| title_sort | molecular functions of wwox potentially involved in cancer development |
| topic | WWOX cancers molecular functions |
| url | https://www.mdpi.com/2073-4409/10/5/1051 |
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