Neurobrucellosis with ischemic stroke and spinal cord involvement: a case report
Abstract Background Brucellosis is a common zoonotic disease that may have a variety of clinical manifestations when it affects the nervous system. Ischemic stroke is a rare clinical symptom, but if it is not diagnosed and treated early, it may cause more severe consequences. Case presentation We re...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-021-02155-2 |
| _version_ | 1818565028040671232 |
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| author | Hongfeng Wen Di Jin Lina Cai Tao Wu Haichao Liu |
| author_facet | Hongfeng Wen Di Jin Lina Cai Tao Wu Haichao Liu |
| author_sort | Hongfeng Wen |
| collection | DOAJ |
| description | Abstract Background Brucellosis is a common zoonotic disease that may have a variety of clinical manifestations when it affects the nervous system. Ischemic stroke is a rare clinical symptom, but if it is not diagnosed and treated early, it may cause more severe consequences. Case presentation We report a 38-year-old man presenting with hearing impairment for four years and sudden weakness of the right limb for two years, recurrent aphasia, and gradual weakness of bilateral lower limbs for nine months. He had bilateral positive Babinski’s sign. Cerebrospinal fluid (CSF) showed raised protein and pleocytosis. Magnetic resonance imaging (MRI) showed ischemic infarcts in the pons and extensive enhancement of spinal meninges combined with spinal cord atrophy and ischemia. The tests revealed Brucella Rose Bengal positive in serum and CSF. Brucella culture in CSF was also positive. Next-generation sequencing (NGS) of CSF revealed positive for Brucella with 105 species were detected. He showed significant improvement with antibiotics at five months follow-up. Conclusions Neurobrucellosis may mimic stroke and transverse myelitis like syndromes. NB is a treatable infectious condition and should always be considered in the differentials, especially if there are risk factors, as in our case. |
| first_indexed | 2024-12-14T01:36:06Z |
| format | Article |
| id | doaj.art-e572eb72b1df4e55b23a3918327edd78 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-14T01:36:06Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-e572eb72b1df4e55b23a3918327edd782022-12-21T23:21:53ZengBMCBMC Neurology1471-23772021-03-012111510.1186/s12883-021-02155-2Neurobrucellosis with ischemic stroke and spinal cord involvement: a case reportHongfeng Wen0Di Jin1Lina Cai2Tao Wu3Haichao Liu4Department of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalDepartment of Neurology, Aerospace Center HospitalAbstract Background Brucellosis is a common zoonotic disease that may have a variety of clinical manifestations when it affects the nervous system. Ischemic stroke is a rare clinical symptom, but if it is not diagnosed and treated early, it may cause more severe consequences. Case presentation We report a 38-year-old man presenting with hearing impairment for four years and sudden weakness of the right limb for two years, recurrent aphasia, and gradual weakness of bilateral lower limbs for nine months. He had bilateral positive Babinski’s sign. Cerebrospinal fluid (CSF) showed raised protein and pleocytosis. Magnetic resonance imaging (MRI) showed ischemic infarcts in the pons and extensive enhancement of spinal meninges combined with spinal cord atrophy and ischemia. The tests revealed Brucella Rose Bengal positive in serum and CSF. Brucella culture in CSF was also positive. Next-generation sequencing (NGS) of CSF revealed positive for Brucella with 105 species were detected. He showed significant improvement with antibiotics at five months follow-up. Conclusions Neurobrucellosis may mimic stroke and transverse myelitis like syndromes. NB is a treatable infectious condition and should always be considered in the differentials, especially if there are risk factors, as in our case.https://doi.org/10.1186/s12883-021-02155-2NeurobrucellosisStrokeSpinal cordCerebrospinal fluid |
| spellingShingle | Hongfeng Wen Di Jin Lina Cai Tao Wu Haichao Liu Neurobrucellosis with ischemic stroke and spinal cord involvement: a case report BMC Neurology Neurobrucellosis Stroke Spinal cord Cerebrospinal fluid |
| title | Neurobrucellosis with ischemic stroke and spinal cord involvement: a case report |
| title_full | Neurobrucellosis with ischemic stroke and spinal cord involvement: a case report |
| title_fullStr | Neurobrucellosis with ischemic stroke and spinal cord involvement: a case report |
| title_full_unstemmed | Neurobrucellosis with ischemic stroke and spinal cord involvement: a case report |
| title_short | Neurobrucellosis with ischemic stroke and spinal cord involvement: a case report |
| title_sort | neurobrucellosis with ischemic stroke and spinal cord involvement a case report |
| topic | Neurobrucellosis Stroke Spinal cord Cerebrospinal fluid |
| url | https://doi.org/10.1186/s12883-021-02155-2 |
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