Biomarkers for monitoring intestinal health in poultry: present status and future perspectives
Abstract Intestinal health is determined by host (immunity, mucosal barrier), nutritional, microbial and environmental factors. Deficiencies in intestinal health are associated with shifts in the composition of the intestinal microbiome (dysbiosis), leakage of the mucosal barrier and/or inflammation...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | Veterinary Research |
| Online Access: | http://link.springer.com/article/10.1186/s13567-018-0538-6 |
| _version_ | 1819077333409071104 |
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| author | Richard Ducatelle Evy Goossens Fien De Meyer Venessa Eeckhaut Gunther Antonissen Freddy Haesebrouck Filip Van Immerseel |
| author_facet | Richard Ducatelle Evy Goossens Fien De Meyer Venessa Eeckhaut Gunther Antonissen Freddy Haesebrouck Filip Van Immerseel |
| author_sort | Richard Ducatelle |
| collection | DOAJ |
| description | Abstract Intestinal health is determined by host (immunity, mucosal barrier), nutritional, microbial and environmental factors. Deficiencies in intestinal health are associated with shifts in the composition of the intestinal microbiome (dysbiosis), leakage of the mucosal barrier and/or inflammation. Since the ban on growth promoting antimicrobials in animal feed, these dysbiosis-related problems have become a major issue, especially in intensive animal farming. The economical and animal welfare consequences are considerable. Consequently, there is a need for continuous monitoring of the intestinal health status, particularly in intensively reared animals, where the intestinal function is often pushed to the limit. In the current review, the recent advances in the field of intestinal health biomarkers, both in human and veterinary medicine are discussed, trying to identify present and future markers of intestinal health in poultry. The most promising new biomarkers will be stable molecules ending up in the feces and litter that can be quantified, preferably using rapid and simple pen-side tests. It is unlikely, however, that a single biomarker will be sufficient to follow up all aspects of intestinal health. Combinations of multiple biomarkers and/or metabarcoding, metagenomic, metatranscriptomic, metaproteomic and metabolomic approaches will be the way to go in the future. Candidate biomarkers currently are being investigated by many research groups, but the validation will be a major challenge, due to the complexity of intestinal health in the field. |
| first_indexed | 2024-12-21T18:55:32Z |
| format | Article |
| id | doaj.art-e5733918f09741b1aec297fc41ba6456 |
| institution | Directory Open Access Journal |
| issn | 1297-9716 |
| language | English |
| last_indexed | 2024-12-21T18:55:32Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Veterinary Research |
| spelling | doaj.art-e5733918f09741b1aec297fc41ba64562022-12-21T18:53:37ZengBMCVeterinary Research1297-97162018-05-014911910.1186/s13567-018-0538-6Biomarkers for monitoring intestinal health in poultry: present status and future perspectivesRichard Ducatelle0Evy Goossens1Fien De Meyer2Venessa Eeckhaut3Gunther Antonissen4Freddy Haesebrouck5Filip Van Immerseel6Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent UniversityDepartment of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent UniversityDepartment of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent UniversityDepartment of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent UniversityDepartment of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent UniversityDepartment of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent UniversityDepartment of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent UniversityAbstract Intestinal health is determined by host (immunity, mucosal barrier), nutritional, microbial and environmental factors. Deficiencies in intestinal health are associated with shifts in the composition of the intestinal microbiome (dysbiosis), leakage of the mucosal barrier and/or inflammation. Since the ban on growth promoting antimicrobials in animal feed, these dysbiosis-related problems have become a major issue, especially in intensive animal farming. The economical and animal welfare consequences are considerable. Consequently, there is a need for continuous monitoring of the intestinal health status, particularly in intensively reared animals, where the intestinal function is often pushed to the limit. In the current review, the recent advances in the field of intestinal health biomarkers, both in human and veterinary medicine are discussed, trying to identify present and future markers of intestinal health in poultry. The most promising new biomarkers will be stable molecules ending up in the feces and litter that can be quantified, preferably using rapid and simple pen-side tests. It is unlikely, however, that a single biomarker will be sufficient to follow up all aspects of intestinal health. Combinations of multiple biomarkers and/or metabarcoding, metagenomic, metatranscriptomic, metaproteomic and metabolomic approaches will be the way to go in the future. Candidate biomarkers currently are being investigated by many research groups, but the validation will be a major challenge, due to the complexity of intestinal health in the field.http://link.springer.com/article/10.1186/s13567-018-0538-6 |
| spellingShingle | Richard Ducatelle Evy Goossens Fien De Meyer Venessa Eeckhaut Gunther Antonissen Freddy Haesebrouck Filip Van Immerseel Biomarkers for monitoring intestinal health in poultry: present status and future perspectives Veterinary Research |
| title | Biomarkers for monitoring intestinal health in poultry: present status and future perspectives |
| title_full | Biomarkers for monitoring intestinal health in poultry: present status and future perspectives |
| title_fullStr | Biomarkers for monitoring intestinal health in poultry: present status and future perspectives |
| title_full_unstemmed | Biomarkers for monitoring intestinal health in poultry: present status and future perspectives |
| title_short | Biomarkers for monitoring intestinal health in poultry: present status and future perspectives |
| title_sort | biomarkers for monitoring intestinal health in poultry present status and future perspectives |
| url | http://link.springer.com/article/10.1186/s13567-018-0538-6 |
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