Astragaloside IV Improves Bleomycin-Induced Pulmonary Fibrosis in Rats by Attenuating Extracellular Matrix Deposition

Astragaloside IV Improves Bleomycin-Induced Pulmonary Fibrosis in Rats by Attenuating Extracellular Matrix Deposition

Pulmonary fibrosis is a devastating lung disorder with mysterious pathogenesis and limited treatment options. It is well-recognized that the uncontrolled proliferation of lung fibroblasts and differentiation of fibroblasts into myofibroblasts excessively produce extracellular matrix (ECM) proteins w...

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Bibliographic Details
Main Authors: Liu-Cheng Li, Liang Xu, Yan Hu, Wen-Jie Cui, Wen-Hui Cui, Wen-Cheng Zhou, Lian-Di Kan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary fibrosis
bleomycin
astragaloside IV
extracellular matrix
high-mobility group box1
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00513/full

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