Modification of Vegetable Proteins to Release Bioactive Peptides Able to Treat Metabolic Syndrome—In Silico Assessment
Metabolic syndrome comprises a cluster of diseases like hypertension, dyslipidemia, and insulin resistance, among others. Its treatment is based on lifestyle modification; however, this treatment often fails to improve metabolic syndrome indicators over the long term. In this work, sequences of some...
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MDPI AG
2020-04-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/10/7/2604 |
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| author | Diego Armando Maldonado-Torres D. Alejandro Fernández-Velasco Gema Morales-Olán Flor de Fátima Rosas-Cárdenas Silvia Luna-Suárez |
| author_facet | Diego Armando Maldonado-Torres D. Alejandro Fernández-Velasco Gema Morales-Olán Flor de Fátima Rosas-Cárdenas Silvia Luna-Suárez |
| author_sort | Diego Armando Maldonado-Torres |
| collection | DOAJ |
| description | Metabolic syndrome comprises a cluster of diseases like hypertension, dyslipidemia, and insulin resistance, among others. Its treatment is based on lifestyle modification; however, this treatment often fails to improve metabolic syndrome indicators over the long term. In this work, sequences of some representative vegetable proteins were explored to find bioactive peptides with activity toward metabolic disorders of metabolic syndrome. Five proteins, i.e., legumin (chickpea), glutelin type A-2 (chickpea), glutelin type B-2 (rice), prolamin PPROL 17 (maize), and glutelin (rice) revealed a high potential to be effective against metabolic syndrome. We designed and evaluated in silico modifications to their amino acid sequence to release bioactive peptides after simulating gastrointestinal digestion (SGD). The approach presented here allows the design of proteins that could combat metabolic syndrome, for later production and study. In the future, these proteins can be used as functional foods. |
| first_indexed | 2024-03-10T20:34:21Z |
| format | Article |
| id | doaj.art-e57b25fd427f49488c13ed39509337c2 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T20:34:21Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-e57b25fd427f49488c13ed39509337c22023-11-19T21:11:53ZengMDPI AGApplied Sciences2076-34172020-04-01107260410.3390/app10072604Modification of Vegetable Proteins to Release Bioactive Peptides Able to Treat Metabolic Syndrome—In Silico AssessmentDiego Armando Maldonado-Torres0D. Alejandro Fernández-Velasco1Gema Morales-Olán2Flor de Fátima Rosas-Cárdenas3Silvia Luna-Suárez4Centro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, CIBA-IPN, Carretera estatal Tecuexcomac-Tepetitla Km. 1.5, Tepetitla 90700, Tlaxcala, MexicoLaboratorio de Fisicoquímica e Ingeniería de Proteínas, Departamento de Bioquímica, Facultad de Medicina, UNAM, Ciudad de México 04510, MexicoCentro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, CIBA-IPN, Carretera estatal Tecuexcomac-Tepetitla Km. 1.5, Tepetitla 90700, Tlaxcala, MexicoCentro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, CIBA-IPN, Carretera estatal Tecuexcomac-Tepetitla Km. 1.5, Tepetitla 90700, Tlaxcala, MexicoCentro de Investigación en Biotecnología Aplicada, Instituto Politécnico Nacional, CIBA-IPN, Carretera estatal Tecuexcomac-Tepetitla Km. 1.5, Tepetitla 90700, Tlaxcala, MexicoMetabolic syndrome comprises a cluster of diseases like hypertension, dyslipidemia, and insulin resistance, among others. Its treatment is based on lifestyle modification; however, this treatment often fails to improve metabolic syndrome indicators over the long term. In this work, sequences of some representative vegetable proteins were explored to find bioactive peptides with activity toward metabolic disorders of metabolic syndrome. Five proteins, i.e., legumin (chickpea), glutelin type A-2 (chickpea), glutelin type B-2 (rice), prolamin PPROL 17 (maize), and glutelin (rice) revealed a high potential to be effective against metabolic syndrome. We designed and evaluated in silico modifications to their amino acid sequence to release bioactive peptides after simulating gastrointestinal digestion (SGD). The approach presented here allows the design of proteins that could combat metabolic syndrome, for later production and study. In the future, these proteins can be used as functional foods.https://www.mdpi.com/2076-3417/10/7/2604metabolic syndromebioactive peptidesstorage proteinsin silico design |
| spellingShingle | Diego Armando Maldonado-Torres D. Alejandro Fernández-Velasco Gema Morales-Olán Flor de Fátima Rosas-Cárdenas Silvia Luna-Suárez Modification of Vegetable Proteins to Release Bioactive Peptides Able to Treat Metabolic Syndrome—In Silico Assessment Applied Sciences metabolic syndrome bioactive peptides storage proteins in silico design |
| title | Modification of Vegetable Proteins to Release Bioactive Peptides Able to Treat Metabolic Syndrome—In Silico Assessment |
| title_full | Modification of Vegetable Proteins to Release Bioactive Peptides Able to Treat Metabolic Syndrome—In Silico Assessment |
| title_fullStr | Modification of Vegetable Proteins to Release Bioactive Peptides Able to Treat Metabolic Syndrome—In Silico Assessment |
| title_full_unstemmed | Modification of Vegetable Proteins to Release Bioactive Peptides Able to Treat Metabolic Syndrome—In Silico Assessment |
| title_short | Modification of Vegetable Proteins to Release Bioactive Peptides Able to Treat Metabolic Syndrome—In Silico Assessment |
| title_sort | modification of vegetable proteins to release bioactive peptides able to treat metabolic syndrome in silico assessment |
| topic | metabolic syndrome bioactive peptides storage proteins in silico design |
| url | https://www.mdpi.com/2076-3417/10/7/2604 |
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