The Oak–Wood Extract Robuvit<sup>®</sup> Improves Recovery and Oxidative Stress after Hysterectomy: A Randomized, Double-blind, Placebo-Controlled Pilot Study
Hysterectomy has a variety of medical indications and improves pre-operative symptoms but might compromise the quality of life during recovery due to symptoms such as fatigue, headache, nausea, depression, or pain. The aim of the present study was to determine the effect of a standardized extract fr...
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MDPI AG
2020-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/4/913 |
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| author | Vladimír Ferianec Matej Fülöp Miriam Ježovičová Jana Radošinská Marta Husseinová Michaela Feriancová Dominika Radošinská Miroslav Barančík Jana Muchová Petra Hȍgger Zdeňka Ďuračková |
| author_facet | Vladimír Ferianec Matej Fülöp Miriam Ježovičová Jana Radošinská Marta Husseinová Michaela Feriancová Dominika Radošinská Miroslav Barančík Jana Muchová Petra Hȍgger Zdeňka Ďuračková |
| author_sort | Vladimír Ferianec |
| collection | DOAJ |
| description | Hysterectomy has a variety of medical indications and improves pre-operative symptoms but might compromise the quality of life during recovery due to symptoms such as fatigue, headache, nausea, depression, or pain. The aim of the present study was to determine the effect of a standardized extract from French oak wood (<i>Quercus robur</i>) containing at least 40% polyphenols of the ellagitannins class, Robuvit<sup>®</sup>, on convalescence and oxidative stress of women after hysterectomy. Recovery status was monitored with the SF-36 questionnaire. The supplementation with Robuvit<sup>®</sup> (300 mg/day) during 4 weeks significantly improved general and mental health, while under placebo some items significantly deteriorated. Oxidative stress and enhancement of MMP–9 activity was significantly reduced by Robuvit<sup>®</sup> versus placebo. After 8 weeks of intervention, the patients’ condition improved independently of the intervention. Our results suggest that the use of Robuvit<sup>®</sup> as a natural supplement relieves post-operative symptoms of patients after hysterectomy and reduces oxidative stress. The study was registered with ID ISRCTN 11457040 (13/09/2019). |
| first_indexed | 2024-03-11T10:13:17Z |
| format | Article |
| id | doaj.art-e57b4c1955e147668cb68df66e6bd7b0 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T10:13:17Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e57b4c1955e147668cb68df66e6bd7b02023-11-16T14:25:49ZengMDPI AGNutrients2072-66432020-03-0112491310.3390/nu12040913The Oak–Wood Extract Robuvit<sup>®</sup> Improves Recovery and Oxidative Stress after Hysterectomy: A Randomized, Double-blind, Placebo-Controlled Pilot StudyVladimír Ferianec0Matej Fülöp1Miriam Ježovičová2Jana Radošinská3Marta Husseinová4Michaela Feriancová5Dominika Radošinská6Miroslav Barančík7Jana Muchová8Petra Hȍgger9Zdeňka Ďuračková10Department of II. Gynecology and Obstetrics, Medical Faculty, Comenius University, 82606 Bratislava, SlovakiaInstitute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Medical Faculty, Comenius University, 81108 Bratislava, SlovakiaInstitute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Medical Faculty, Comenius University, 81108 Bratislava, SlovakiaInstitute of Physiology, Faculty of Medicine, Comenius University in Bratislava, 81108 Bratislava, SlovakiaInstitute of Physiology, Faculty of Medicine, Comenius University in Bratislava, 81108 Bratislava, SlovakiaDepartment of II. Gynecology and Obstetrics, Medical Faculty, Comenius University, 82606 Bratislava, SlovakiaFaculty of Natural Sciences, Comenius University in Bratislava, 84215 Bratislava, SlovakiaCenter of Experimental Medicine, Institute for Heart Research, Slovak Academy of Sciences, 84104 Bratislava, SlovakiaInstitute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Medical Faculty, Comenius University, 81108 Bratislava, SlovakiaInstitut für Pharmazie und Lebensmittelchemie, Universität Würzburg, 97074 Würzburg, GermanyInstitute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Medical Faculty, Comenius University, 81108 Bratislava, SlovakiaHysterectomy has a variety of medical indications and improves pre-operative symptoms but might compromise the quality of life during recovery due to symptoms such as fatigue, headache, nausea, depression, or pain. The aim of the present study was to determine the effect of a standardized extract from French oak wood (<i>Quercus robur</i>) containing at least 40% polyphenols of the ellagitannins class, Robuvit<sup>®</sup>, on convalescence and oxidative stress of women after hysterectomy. Recovery status was monitored with the SF-36 questionnaire. The supplementation with Robuvit<sup>®</sup> (300 mg/day) during 4 weeks significantly improved general and mental health, while under placebo some items significantly deteriorated. Oxidative stress and enhancement of MMP–9 activity was significantly reduced by Robuvit<sup>®</sup> versus placebo. After 8 weeks of intervention, the patients’ condition improved independently of the intervention. Our results suggest that the use of Robuvit<sup>®</sup> as a natural supplement relieves post-operative symptoms of patients after hysterectomy and reduces oxidative stress. The study was registered with ID ISRCTN 11457040 (13/09/2019).https://www.mdpi.com/2072-6643/12/4/913hysterectomyRobuvit<sup>®</sup>oak wood extractpost-operative recoveryoxidative stressmatrix metalloproteinases |
| spellingShingle | Vladimír Ferianec Matej Fülöp Miriam Ježovičová Jana Radošinská Marta Husseinová Michaela Feriancová Dominika Radošinská Miroslav Barančík Jana Muchová Petra Hȍgger Zdeňka Ďuračková The Oak–Wood Extract Robuvit<sup>®</sup> Improves Recovery and Oxidative Stress after Hysterectomy: A Randomized, Double-blind, Placebo-Controlled Pilot Study Nutrients hysterectomy Robuvit<sup>®</sup> oak wood extract post-operative recovery oxidative stress matrix metalloproteinases |
| title | The Oak–Wood Extract Robuvit<sup>®</sup> Improves Recovery and Oxidative Stress after Hysterectomy: A Randomized, Double-blind, Placebo-Controlled Pilot Study |
| title_full | The Oak–Wood Extract Robuvit<sup>®</sup> Improves Recovery and Oxidative Stress after Hysterectomy: A Randomized, Double-blind, Placebo-Controlled Pilot Study |
| title_fullStr | The Oak–Wood Extract Robuvit<sup>®</sup> Improves Recovery and Oxidative Stress after Hysterectomy: A Randomized, Double-blind, Placebo-Controlled Pilot Study |
| title_full_unstemmed | The Oak–Wood Extract Robuvit<sup>®</sup> Improves Recovery and Oxidative Stress after Hysterectomy: A Randomized, Double-blind, Placebo-Controlled Pilot Study |
| title_short | The Oak–Wood Extract Robuvit<sup>®</sup> Improves Recovery and Oxidative Stress after Hysterectomy: A Randomized, Double-blind, Placebo-Controlled Pilot Study |
| title_sort | oak wood extract robuvit sup r sup improves recovery and oxidative stress after hysterectomy a randomized double blind placebo controlled pilot study |
| topic | hysterectomy Robuvit<sup>®</sup> oak wood extract post-operative recovery oxidative stress matrix metalloproteinases |
| url | https://www.mdpi.com/2072-6643/12/4/913 |
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