Added Value of Biophysics to Study Lipid-Driven Biological Processes: The Case of Surfactins, a Class of Natural Amphiphile Molecules
The role of membrane lipids is increasingly claimed to explain biological activities of natural amphiphile molecules. To decipher this role, biophysical studies with biomimetic membrane models are often helpful to obtain insights at the molecular and atomic levels. In this review, the added value of...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/13831 |
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| author | Guillaume Gilliard Aurélien L. Furlan Willy Smeralda Jelena Pršić Magali Deleu |
| author_facet | Guillaume Gilliard Aurélien L. Furlan Willy Smeralda Jelena Pršić Magali Deleu |
| author_sort | Guillaume Gilliard |
| collection | DOAJ |
| description | The role of membrane lipids is increasingly claimed to explain biological activities of natural amphiphile molecules. To decipher this role, biophysical studies with biomimetic membrane models are often helpful to obtain insights at the molecular and atomic levels. In this review, the added value of biophysics to study lipid-driven biological processes is illustrated using the case of surfactins, a class of natural lipopeptides produced by <i>Bacillus</i> sp. showing a broad range of biological activities. The mechanism of interaction of surfactins with biomimetic models showed to be dependent on the surfactins-to-lipid ratio with action as membrane disturber without membrane lysis at low and intermediate ratios and a membrane permeabilizing effect at higher ratios. These two mechanisms are relevant to explain surfactins’ biological activities occurring without membrane lysis, such as their antiviral and plant immunity-eliciting activities, and the one involving cell lysis, such as their antibacterial and hemolytic activities. In both biological and biophysical studies, influence of surfactin structure and membrane lipids on the mechanisms was observed with a similar trend. Hence, biomimetic models represent interesting tools to elucidate the biological mechanisms targeting membrane lipids and can contribute to the development of new molecules for pharmaceutical or agronomic applications. |
| first_indexed | 2024-03-09T18:18:08Z |
| format | Article |
| id | doaj.art-e57c6cd8577f43738732dc8ba97306c7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:18:08Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e57c6cd8577f43738732dc8ba97306c72023-11-24T08:34:16ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221383110.3390/ijms232213831Added Value of Biophysics to Study Lipid-Driven Biological Processes: The Case of Surfactins, a Class of Natural Amphiphile MoleculesGuillaume Gilliard0Aurélien L. Furlan1Willy Smeralda2Jelena Pršić3Magali Deleu4Laboratoire de Biophysique Moléculaire aux Interfaces, Gembloux Agro-Bio Tech, Université de Liège, 2 Passage des Déportés, B-5030 Gembloux, BelgiumLaboratoire de Biophysique Moléculaire aux Interfaces, Gembloux Agro-Bio Tech, Université de Liège, 2 Passage des Déportés, B-5030 Gembloux, BelgiumLaboratoire de Biophysique Moléculaire aux Interfaces, Gembloux Agro-Bio Tech, Université de Liège, 2 Passage des Déportés, B-5030 Gembloux, BelgiumLaboratoire de Biophysique Moléculaire aux Interfaces, Gembloux Agro-Bio Tech, Université de Liège, 2 Passage des Déportés, B-5030 Gembloux, BelgiumLaboratoire de Biophysique Moléculaire aux Interfaces, Gembloux Agro-Bio Tech, Université de Liège, 2 Passage des Déportés, B-5030 Gembloux, BelgiumThe role of membrane lipids is increasingly claimed to explain biological activities of natural amphiphile molecules. To decipher this role, biophysical studies with biomimetic membrane models are often helpful to obtain insights at the molecular and atomic levels. In this review, the added value of biophysics to study lipid-driven biological processes is illustrated using the case of surfactins, a class of natural lipopeptides produced by <i>Bacillus</i> sp. showing a broad range of biological activities. The mechanism of interaction of surfactins with biomimetic models showed to be dependent on the surfactins-to-lipid ratio with action as membrane disturber without membrane lysis at low and intermediate ratios and a membrane permeabilizing effect at higher ratios. These two mechanisms are relevant to explain surfactins’ biological activities occurring without membrane lysis, such as their antiviral and plant immunity-eliciting activities, and the one involving cell lysis, such as their antibacterial and hemolytic activities. In both biological and biophysical studies, influence of surfactin structure and membrane lipids on the mechanisms was observed with a similar trend. Hence, biomimetic models represent interesting tools to elucidate the biological mechanisms targeting membrane lipids and can contribute to the development of new molecules for pharmaceutical or agronomic applications.https://www.mdpi.com/1422-0067/23/22/13831surfactinbiomimetic membrane modelsmolecular biophysicslipid-mediated sensingmembrane interactionsbiological mechanism |
| spellingShingle | Guillaume Gilliard Aurélien L. Furlan Willy Smeralda Jelena Pršić Magali Deleu Added Value of Biophysics to Study Lipid-Driven Biological Processes: The Case of Surfactins, a Class of Natural Amphiphile Molecules International Journal of Molecular Sciences surfactin biomimetic membrane models molecular biophysics lipid-mediated sensing membrane interactions biological mechanism |
| title | Added Value of Biophysics to Study Lipid-Driven Biological Processes: The Case of Surfactins, a Class of Natural Amphiphile Molecules |
| title_full | Added Value of Biophysics to Study Lipid-Driven Biological Processes: The Case of Surfactins, a Class of Natural Amphiphile Molecules |
| title_fullStr | Added Value of Biophysics to Study Lipid-Driven Biological Processes: The Case of Surfactins, a Class of Natural Amphiphile Molecules |
| title_full_unstemmed | Added Value of Biophysics to Study Lipid-Driven Biological Processes: The Case of Surfactins, a Class of Natural Amphiphile Molecules |
| title_short | Added Value of Biophysics to Study Lipid-Driven Biological Processes: The Case of Surfactins, a Class of Natural Amphiphile Molecules |
| title_sort | added value of biophysics to study lipid driven biological processes the case of surfactins a class of natural amphiphile molecules |
| topic | surfactin biomimetic membrane models molecular biophysics lipid-mediated sensing membrane interactions biological mechanism |
| url | https://www.mdpi.com/1422-0067/23/22/13831 |
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