GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population
Objective. Many conflicting results have been obtained in the study of leptin (LEP) and leptin receptor (LEPR) gene variants that are associated with the obesity and diabetes possibly due to differences in the study populations. The aim of this study was to evaluate changes in the metabolic hormones...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2023-01-01
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| Series: | Endocrine Regulations |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/enr-2023-0030 |
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| author | Prodan Andrii Dzubanovsky Ihor Kamyshnyi Oleksandr Melnyk Natalia Pidruchna Svitlana Voloshyn Stanislava |
| author_facet | Prodan Andrii Dzubanovsky Ihor Kamyshnyi Oleksandr Melnyk Natalia Pidruchna Svitlana Voloshyn Stanislava |
| author_sort | Prodan Andrii |
| collection | DOAJ |
| description | Objective. Many conflicting results have been obtained in the study of leptin (LEP) and leptin receptor (LEPR) gene variants that are associated with the obesity and diabetes possibly due to differences in the study populations. The aim of this study was to evaluate changes in the metabolic hormones (leptin, ghrelin, adiponectin, resistin) levels in the blood of obese patients in relation to the GHRL (rs696217), LEP (rs7799039), LEPR (rs1137100, rs1137101, rs1805094) polymorphism in Ukrainian population. |
| first_indexed | 2024-03-08T19:31:55Z |
| format | Article |
| id | doaj.art-e57d4869f8764e2ab0e1b91b7ad46379 |
| institution | Directory Open Access Journal |
| issn | 1336-0329 |
| language | English |
| last_indexed | 2024-03-08T19:31:55Z |
| publishDate | 2023-01-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Endocrine Regulations |
| spelling | doaj.art-e57d4869f8764e2ab0e1b91b7ad463792023-12-26T07:42:09ZengSciendoEndocrine Regulations1336-03292023-01-0157126927810.2478/enr-2023-0030GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian populationProdan Andrii0Dzubanovsky Ihor1Kamyshnyi Oleksandr2Melnyk Natalia3Pidruchna Svitlana4Voloshyn Stanislava51Department of Surgery of Postgraduate Faculty1Department of Surgery of Postgraduate Faculty2Department of Microbiology, Virology, and Immunology3Department of General Hygiene and Ecology4Department of Medical Biochemistry5Department of Pediatrics No2, I. Horbachevsky Ternopil National Medical University, Ternopil, UkraineObjective. Many conflicting results have been obtained in the study of leptin (LEP) and leptin receptor (LEPR) gene variants that are associated with the obesity and diabetes possibly due to differences in the study populations. The aim of this study was to evaluate changes in the metabolic hormones (leptin, ghrelin, adiponectin, resistin) levels in the blood of obese patients in relation to the GHRL (rs696217), LEP (rs7799039), LEPR (rs1137100, rs1137101, rs1805094) polymorphism in Ukrainian population.https://doi.org/10.2478/enr-2023-0030metabolic syndromeleprlepghrl gene polymorphismadiponectinresistinghrelinleptin |
| spellingShingle | Prodan Andrii Dzubanovsky Ihor Kamyshnyi Oleksandr Melnyk Natalia Pidruchna Svitlana Voloshyn Stanislava GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population Endocrine Regulations metabolic syndrome lepr lep ghrl gene polymorphism adiponectin resistin ghrelin leptin |
| title | GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population |
| title_full | GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population |
| title_fullStr | GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population |
| title_full_unstemmed | GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population |
| title_short | GHRL, LEP, LEPR genes polymorphism and their association with the metabolic syndrome in the Ukrainian population |
| title_sort | ghrl lep lepr genes polymorphism and their association with the metabolic syndrome in the ukrainian population |
| topic | metabolic syndrome lepr lep ghrl gene polymorphism adiponectin resistin ghrelin leptin |
| url | https://doi.org/10.2478/enr-2023-0030 |
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