T-cell leukemogenesis is an inappropriate lineage decision-making process: implications for precision oncology

T-cell leukemogenesis is an inappropriate lineage decision-making process: implications for precision oncology

Genetic lineage tracing in cell type-specific mouse models of T-cell acute lymphoblastic leukemia (T-ALL) have revealed that tumor cell identity is imposed by expression of the oncogene Lim Domain Only 2 (LMO2), rather than by the target cell phenotype. This approach allowed to identify that seconda...

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Bibliographic Details
Main Authors: Guillermo Rodríguez-Hernández, Sanil Bhatia, Carolina Vicente-Dueñas, Arndt Borkhardt, Julia Hauer, Isidro Sánchez-García
Format: Article
Language:English
Published: Taylor & Francis Group 2018-07-01
Series:Molecular & Cellular Oncology
Subjects:
lmo2
notch1
stem cells
cancer
mouse models
target cell
cancer cell-of-origin
cancer-stem-cell and tumor reprogramming
Online Access:http://dx.doi.org/10.1080/23723556.2018.1497860

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