Pharmacogenetic Testing in Acute and Chronic Pain: A Preliminary Study
<i>Background and Objectives: </i>Pain is one of the most common symptoms that weighs on life’s quality and health expenditure. In a reality where increasingly personalized therapies are needed, the early use of genetic tests that highlights the individual response to analgesic drugs cou...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/5/147 |
| _version_ | 1797721737729671168 |
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| author | Lorenzo Panella Laura Volontè Nicola Poloni Antonello Caserta Marta Ielmini Ivano Caselli Giulia Lucca Camilla Callegari |
| author_facet | Lorenzo Panella Laura Volontè Nicola Poloni Antonello Caserta Marta Ielmini Ivano Caselli Giulia Lucca Camilla Callegari |
| author_sort | Lorenzo Panella |
| collection | DOAJ |
| description | <i>Background and Objectives: </i>Pain is one of the most common symptoms that weighs on life’s quality and health expenditure. In a reality where increasingly personalized therapies are needed, the early use of genetic tests that highlights the individual response to analgesic drugs could be a valuable help in clinical practice. The aim of this preliminary study is to observe if the therapy set to 5 patients suffering of chronic or acute pain is concordant to the Pharmacogenetic test (PGT) results. <i>Materials and Methods: </i>This preliminary study compares the genetic results of pharmacological effectiveness and tolerability analyzed by the genetic test Neurofarmagen Analgesia, with the results obtained in clinical practice of 5 patients suffering from acute and chronic pain. <i>Results:</i> Regarding the genetic results of the 5 samples analyzed, 2 reports were found to be completely comparable with the evidences of the clinical practice, while in 3 reports the profile of tolerability and effectiveness were partially discordant. <i>Conclusion: </i>In light of the data not completely overlapping with results observed in clinical practice, further studies would be appropriate in order to acquire more information on the use of Neurofarmagen<i> </i>in routine clinical settings. |
| first_indexed | 2024-03-12T09:37:39Z |
| format | Article |
| id | doaj.art-e57f6291181c4faba897e87c72e55777 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T09:37:39Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-e57f6291181c4faba897e87c72e557772023-09-02T13:32:09ZengMDPI AGMedicina1010-660X2019-05-0155514710.3390/medicina55050147medicina55050147Pharmacogenetic Testing in Acute and Chronic Pain: A Preliminary StudyLorenzo Panella0Laura Volontè1Nicola Poloni2Antonello Caserta3Marta Ielmini4Ivano Caselli5Giulia Lucca6Camilla Callegari7Department of Rehabilitation, ASST Gaetano Pini—CTO, Via Isocrate 19, 20122 Milan, ItalyDepartment of Rehabilitation, ASST Gaetano Pini—CTO, Via Isocrate 19, 20122 Milan, ItalyDepartment of Medicine and Surgery, Division of Psychiatry, University of Insubria, Viale Luigi Borri 57, 21100 Varese, ItalyDepartment of Rehabilitation, ASST Gaetano Pini—CTO, Via Isocrate 19, 20122 Milan, ItalyDepartment of Medicine and Surgery, Division of Psychiatry, University of Insubria, Viale Luigi Borri 57, 21100 Varese, ItalyDepartment of Medicine and Surgery, Division of Psychiatry, University of Insubria, Viale Luigi Borri 57, 21100 Varese, ItalyDepartment of Medicine and Surgery, Division of Psychiatry, University of Insubria, Viale Luigi Borri 57, 21100 Varese, ItalyDepartment of Medicine and Surgery, Division of Psychiatry, University of Insubria, Viale Luigi Borri 57, 21100 Varese, Italy<i>Background and Objectives: </i>Pain is one of the most common symptoms that weighs on life’s quality and health expenditure. In a reality where increasingly personalized therapies are needed, the early use of genetic tests that highlights the individual response to analgesic drugs could be a valuable help in clinical practice. The aim of this preliminary study is to observe if the therapy set to 5 patients suffering of chronic or acute pain is concordant to the Pharmacogenetic test (PGT) results. <i>Materials and Methods: </i>This preliminary study compares the genetic results of pharmacological effectiveness and tolerability analyzed by the genetic test Neurofarmagen Analgesia, with the results obtained in clinical practice of 5 patients suffering from acute and chronic pain. <i>Results:</i> Regarding the genetic results of the 5 samples analyzed, 2 reports were found to be completely comparable with the evidences of the clinical practice, while in 3 reports the profile of tolerability and effectiveness were partially discordant. <i>Conclusion: </i>In light of the data not completely overlapping with results observed in clinical practice, further studies would be appropriate in order to acquire more information on the use of Neurofarmagen<i> </i>in routine clinical settings.https://www.mdpi.com/1010-660X/55/5/147painanalgesicpharmacogenetic testingpharmacological therapyeffectivenessadverse effects |
| spellingShingle | Lorenzo Panella Laura Volontè Nicola Poloni Antonello Caserta Marta Ielmini Ivano Caselli Giulia Lucca Camilla Callegari Pharmacogenetic Testing in Acute and Chronic Pain: A Preliminary Study Medicina pain analgesic pharmacogenetic testing pharmacological therapy effectiveness adverse effects |
| title | Pharmacogenetic Testing in Acute and Chronic Pain: A Preliminary Study |
| title_full | Pharmacogenetic Testing in Acute and Chronic Pain: A Preliminary Study |
| title_fullStr | Pharmacogenetic Testing in Acute and Chronic Pain: A Preliminary Study |
| title_full_unstemmed | Pharmacogenetic Testing in Acute and Chronic Pain: A Preliminary Study |
| title_short | Pharmacogenetic Testing in Acute and Chronic Pain: A Preliminary Study |
| title_sort | pharmacogenetic testing in acute and chronic pain a preliminary study |
| topic | pain analgesic pharmacogenetic testing pharmacological therapy effectiveness adverse effects |
| url | https://www.mdpi.com/1010-660X/55/5/147 |
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