Treated Dentin Matrix in Tissue Regeneration: Recent Advances
Tissue engineering is a new therapeutic strategy used to repair serious damage caused by trauma, a tumor or other major diseases, either for vital organs or tissues sited in the oral cavity. Scaffold materials are an indispensable part of this. As an extracellular-matrix-based bio-material, treated...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/1/91 |
| _version_ | 1797437875755679744 |
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| author | Fei Bi Zhijun Zhang Weihua Guo |
| author_facet | Fei Bi Zhijun Zhang Weihua Guo |
| author_sort | Fei Bi |
| collection | DOAJ |
| description | Tissue engineering is a new therapeutic strategy used to repair serious damage caused by trauma, a tumor or other major diseases, either for vital organs or tissues sited in the oral cavity. Scaffold materials are an indispensable part of this. As an extracellular-matrix-based bio-material, treated dentin matrixes have become promising tissue engineering scaffolds due to their unique natural structure, astonishing biological induction activity and benign bio-compatibility. Furthermore, it is important to note that besides its high bio-activity, a treated dentin matrix can also serve as a carrier and release controller for drug molecules and bio-active agents to contribute to tissue regeneration and immunomodulation processes. This paper describes the research advances of treated dentin matrixes in tissue regeneration from the aspects of its vital properties, biologically inductive abilities and application explorations. Furthermore, we present the concerning challenges of signaling mechanisms, source extension, individualized 3D printing and drug delivery system construction during our investigation into the treated dentin matrix. This paper is expected to provide a reference for further research on treated dentin matrixes in tissue regeneration and better promote the development of relevant disease treatment approaches. |
| first_indexed | 2024-03-09T11:28:57Z |
| format | Article |
| id | doaj.art-e58121f99ff646d697ea630d07f5f172 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:28:57Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-e58121f99ff646d697ea630d07f5f1722023-11-30T23:57:31ZengMDPI AGPharmaceutics1999-49232022-12-011519110.3390/pharmaceutics15010091Treated Dentin Matrix in Tissue Regeneration: Recent AdvancesFei Bi0Zhijun Zhang1Weihua Guo2State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610017, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610017, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610017, ChinaTissue engineering is a new therapeutic strategy used to repair serious damage caused by trauma, a tumor or other major diseases, either for vital organs or tissues sited in the oral cavity. Scaffold materials are an indispensable part of this. As an extracellular-matrix-based bio-material, treated dentin matrixes have become promising tissue engineering scaffolds due to their unique natural structure, astonishing biological induction activity and benign bio-compatibility. Furthermore, it is important to note that besides its high bio-activity, a treated dentin matrix can also serve as a carrier and release controller for drug molecules and bio-active agents to contribute to tissue regeneration and immunomodulation processes. This paper describes the research advances of treated dentin matrixes in tissue regeneration from the aspects of its vital properties, biologically inductive abilities and application explorations. Furthermore, we present the concerning challenges of signaling mechanisms, source extension, individualized 3D printing and drug delivery system construction during our investigation into the treated dentin matrix. This paper is expected to provide a reference for further research on treated dentin matrixes in tissue regeneration and better promote the development of relevant disease treatment approaches.https://www.mdpi.com/1999-4923/15/1/91treated dentin matrixbio-materialbio-induction activitytissue regeneration |
| spellingShingle | Fei Bi Zhijun Zhang Weihua Guo Treated Dentin Matrix in Tissue Regeneration: Recent Advances Pharmaceutics treated dentin matrix bio-material bio-induction activity tissue regeneration |
| title | Treated Dentin Matrix in Tissue Regeneration: Recent Advances |
| title_full | Treated Dentin Matrix in Tissue Regeneration: Recent Advances |
| title_fullStr | Treated Dentin Matrix in Tissue Regeneration: Recent Advances |
| title_full_unstemmed | Treated Dentin Matrix in Tissue Regeneration: Recent Advances |
| title_short | Treated Dentin Matrix in Tissue Regeneration: Recent Advances |
| title_sort | treated dentin matrix in tissue regeneration recent advances |
| topic | treated dentin matrix bio-material bio-induction activity tissue regeneration |
| url | https://www.mdpi.com/1999-4923/15/1/91 |
| work_keys_str_mv | AT feibi treateddentinmatrixintissueregenerationrecentadvances AT zhijunzhang treateddentinmatrixintissueregenerationrecentadvances AT weihuaguo treateddentinmatrixintissueregenerationrecentadvances |