Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer
Objective: To detect the relationship between molecular subtypes of breast cancer with expressions of androgen receptor, cytokeratin 5/6 (CK5/6)and Ki-67.Materials and Methods: Expressions of androgen receptor, CK5/6 and Ki67 were determined by immunohistochemistry in paraffin-embedded sections obta...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2014-10-01
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| Series: | European Journal of Breast Health |
| Subjects: | |
| Online Access: |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/cinical-significance-of-androgen-receptor-ck-5-6-k/42254
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| _version_ | 1797908566983573504 |
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| author | Münire Kayahan Ufuk Oguz İdiz Zuhal Gucin Fazilet Erozgen Naim Memmi Mahmut Müslümanoğlu |
| author_facet | Münire Kayahan Ufuk Oguz İdiz Zuhal Gucin Fazilet Erozgen Naim Memmi Mahmut Müslümanoğlu |
| author_sort | Münire Kayahan |
| collection | DOAJ |
| description | Objective: To detect the relationship between molecular subtypes of breast cancer with expressions of androgen receptor, cytokeratin 5/6 (CK5/6)and Ki-67.Materials and Methods: Expressions of androgen receptor, CK5/6 and Ki67 were determined by immunohistochemistry in paraffin-embedded sections obtained from 86 invasive breast cancer cases of stages I/IIa/IIb in 4 molecular subtypes. Patients treated for recurrent disease and locally advanced disease were excluded.Results: Forty one luminal A cases, ie. positive estrogen receptor(ER) and/or progesteron receptor (PR) with negative epidermal growth factor receptor (HER2), 14 luminal B, ie. positive ER and/or PR and positive HER2, 14 HER2-enriched (HER2+), ie. negative ER and PR with positive HER2, and 17 triple negative (negative ER and PR and HER2) invasive breast cancers were included. Mean follow-up was 17.46±11.70 mo. Androgen receptornegativity and CK5/6-positivity were significantly more common in HER2+ and triple negative groups. Ki-67 and histological grade were higher in HER2+ group, significantly. Two deaths were triple negative (P=0.04). Androgen receptor-negativity, CK5/6 and Ki-67 status did not affect survival or systemic metastases, significantly. All groups had local recurrences. Local recurrence was significantly associated with androgen receptor-negativity in luminal A and high Ki-67 value in HER2+ groups. Systemic metastases were significantly more common in triple negative and HER2+ groups.Conclusion: Molecular subtypes of breast cancer are prognostic and predictive. Androgen receptor is expressed more commonly in luminal subtypes with better prognosis and androgen receptor negativity is associated with development of local recurrence in luminal A cancers. |
| first_indexed | 2024-04-10T10:55:49Z |
| format | Article |
| id | doaj.art-e581e50ab746468094068254cc51efcf |
| institution | Directory Open Access Journal |
| issn | 2587-0831 |
| language | English |
| last_indexed | 2024-04-10T10:55:49Z |
| publishDate | 2014-10-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | European Journal of Breast Health |
| spelling | doaj.art-e581e50ab746468094068254cc51efcf2023-02-15T16:20:00ZengGalenos Publishing HouseEuropean Journal of Breast Health2587-08312014-10-0110420120810.5152/tjbh.2014.177713049054Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast CancerMünire Kayahan0Ufuk Oguz İdiz1Zuhal Gucin2Fazilet Erozgen3Naim Memmi4Mahmut Müslümanoğlu5 Bezmialem Vakıf Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye Bezmialem Vakıf Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye Bezmialem Vakıf Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye Haseki Eğitim ve Araştırma Hastanesi, Genel Cerrahi Kliniği, İstanbul, Türkiye Bezmialem Vakıf Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye Bezmialem Vakıf Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye Objective: To detect the relationship between molecular subtypes of breast cancer with expressions of androgen receptor, cytokeratin 5/6 (CK5/6)and Ki-67.Materials and Methods: Expressions of androgen receptor, CK5/6 and Ki67 were determined by immunohistochemistry in paraffin-embedded sections obtained from 86 invasive breast cancer cases of stages I/IIa/IIb in 4 molecular subtypes. Patients treated for recurrent disease and locally advanced disease were excluded.Results: Forty one luminal A cases, ie. positive estrogen receptor(ER) and/or progesteron receptor (PR) with negative epidermal growth factor receptor (HER2), 14 luminal B, ie. positive ER and/or PR and positive HER2, 14 HER2-enriched (HER2+), ie. negative ER and PR with positive HER2, and 17 triple negative (negative ER and PR and HER2) invasive breast cancers were included. Mean follow-up was 17.46±11.70 mo. Androgen receptornegativity and CK5/6-positivity were significantly more common in HER2+ and triple negative groups. Ki-67 and histological grade were higher in HER2+ group, significantly. Two deaths were triple negative (P=0.04). Androgen receptor-negativity, CK5/6 and Ki-67 status did not affect survival or systemic metastases, significantly. All groups had local recurrences. Local recurrence was significantly associated with androgen receptor-negativity in luminal A and high Ki-67 value in HER2+ groups. Systemic metastases were significantly more common in triple negative and HER2+ groups.Conclusion: Molecular subtypes of breast cancer are prognostic and predictive. Androgen receptor is expressed more commonly in luminal subtypes with better prognosis and androgen receptor negativity is associated with development of local recurrence in luminal A cancers. http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/cinical-significance-of-androgen-receptor-ck-5-6-k/42254 androgen receptorcytokeratinki-67 antigenmolecular typingbreast cancer |
| spellingShingle | Münire Kayahan Ufuk Oguz İdiz Zuhal Gucin Fazilet Erozgen Naim Memmi Mahmut Müslümanoğlu Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer European Journal of Breast Health androgen receptor cytokeratin ki-67 antigen molecular typing breast cancer |
| title | Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer |
| title_full | Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer |
| title_fullStr | Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer |
| title_full_unstemmed | Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer |
| title_short | Cinical Significance of Androgen Receptor, CK-5/6, KI-67 and Molecular Subtypes in Breast Cancer |
| title_sort | cinical significance of androgen receptor ck 5 6 ki 67 and molecular subtypes in breast cancer |
| topic | androgen receptor cytokeratin ki-67 antigen molecular typing breast cancer |
| url |
http://www.eurjbreasthealth.com/archives/archive-detail/article-preview/cinical-significance-of-androgen-receptor-ck-5-6-k/42254
|
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