Emerging Role of MicroRNAs in the Therapeutic Response in Cervical Cancer: A Systematic Review
Cervical cancer is a common female cancer, with nearly 600,000 cases and more than 300,000 deaths worldwide every year. From a clinical point of view, surgery plays a key role in early cancer management, whereas advanced stages are treated with chemotherapy and/or radiation as adjuvant therapies. Ne...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.847974/full |
| _version_ | 1818532407027957760 |
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| author | Gloria Ravegnini Francesca Gorini Giulia Dondi Giulia Dondi Marco Tesei Eugenia De Crescenzo Eugenia De Crescenzo Alessio G. Morganti Patrizia Hrelia Pierandrea De Iaco Pierandrea De Iaco Sabrina Angelini Anna Myriam Perrone Anna Myriam Perrone |
| author_facet | Gloria Ravegnini Francesca Gorini Giulia Dondi Giulia Dondi Marco Tesei Eugenia De Crescenzo Eugenia De Crescenzo Alessio G. Morganti Patrizia Hrelia Pierandrea De Iaco Pierandrea De Iaco Sabrina Angelini Anna Myriam Perrone Anna Myriam Perrone |
| author_sort | Gloria Ravegnini |
| collection | DOAJ |
| description | Cervical cancer is a common female cancer, with nearly 600,000 cases and more than 300,000 deaths worldwide every year. From a clinical point of view, surgery plays a key role in early cancer management, whereas advanced stages are treated with chemotherapy and/or radiation as adjuvant therapies. Nevertheless, predicting the degree of cancer response to chemotherapy or radiation therapy at diagnosis in order to personalize the clinical approach represents the biggest challenge in locally advanced cancers. The feasibility of such predictive models has been repeatedly assessed using histopathological factors, imaging and nuclear methods, tissue and fluid scans, however with poor results. In this context, the identification of novel potential biomarkers remains an unmet clinical need, and microRNAs (miRNAs) represent an interesting opportunity. With this in mind, the aim of this systematic review was to map the current literature on tumor and circulating miRNAs identified as significantly associated with the therapeutic response in cervical cancer; finally, a perspective point of view sheds light on the challenges ahead in this tumor.Systematic Review RegistrationPROSPERO (CRD42021277980). |
| first_indexed | 2024-12-11T17:45:07Z |
| format | Article |
| id | doaj.art-e58305fd3df2413b8d812e7ad7e90f17 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-11T17:45:07Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e58305fd3df2413b8d812e7ad7e90f172022-12-22T00:56:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.847974847974Emerging Role of MicroRNAs in the Therapeutic Response in Cervical Cancer: A Systematic ReviewGloria Ravegnini0Francesca Gorini1Giulia Dondi2Giulia Dondi3Marco Tesei4Eugenia De Crescenzo5Eugenia De Crescenzo6Alessio G. Morganti7Patrizia Hrelia8Pierandrea De Iaco9Pierandrea De Iaco10Sabrina Angelini11Anna Myriam Perrone12Anna Myriam Perrone13Department of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna, ItalyDepartment of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna, ItalyDivision of Oncologic Gynecology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, ItalyDivision of Oncologic Gynecology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDivision of Oncologic Gynecology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, ItalyDepartment of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna, ItalyDivision of Oncologic Gynecology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, ItalyDepartment of Pharmacy and Biotechnology (FABIT), University of Bologna, Bologna, ItalyDivision of Oncologic Gynecology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDepartment of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, ItalyCervical cancer is a common female cancer, with nearly 600,000 cases and more than 300,000 deaths worldwide every year. From a clinical point of view, surgery plays a key role in early cancer management, whereas advanced stages are treated with chemotherapy and/or radiation as adjuvant therapies. Nevertheless, predicting the degree of cancer response to chemotherapy or radiation therapy at diagnosis in order to personalize the clinical approach represents the biggest challenge in locally advanced cancers. The feasibility of such predictive models has been repeatedly assessed using histopathological factors, imaging and nuclear methods, tissue and fluid scans, however with poor results. In this context, the identification of novel potential biomarkers remains an unmet clinical need, and microRNAs (miRNAs) represent an interesting opportunity. With this in mind, the aim of this systematic review was to map the current literature on tumor and circulating miRNAs identified as significantly associated with the therapeutic response in cervical cancer; finally, a perspective point of view sheds light on the challenges ahead in this tumor.Systematic Review RegistrationPROSPERO (CRD42021277980).https://www.frontiersin.org/articles/10.3389/fonc.2022.847974/fullcervical cancermiRNAsradiotherapychemotherapyHPVtherapeutic response |
| spellingShingle | Gloria Ravegnini Francesca Gorini Giulia Dondi Giulia Dondi Marco Tesei Eugenia De Crescenzo Eugenia De Crescenzo Alessio G. Morganti Patrizia Hrelia Pierandrea De Iaco Pierandrea De Iaco Sabrina Angelini Anna Myriam Perrone Anna Myriam Perrone Emerging Role of MicroRNAs in the Therapeutic Response in Cervical Cancer: A Systematic Review Frontiers in Oncology cervical cancer miRNAs radiotherapy chemotherapy HPV therapeutic response |
| title | Emerging Role of MicroRNAs in the Therapeutic Response in Cervical Cancer: A Systematic Review |
| title_full | Emerging Role of MicroRNAs in the Therapeutic Response in Cervical Cancer: A Systematic Review |
| title_fullStr | Emerging Role of MicroRNAs in the Therapeutic Response in Cervical Cancer: A Systematic Review |
| title_full_unstemmed | Emerging Role of MicroRNAs in the Therapeutic Response in Cervical Cancer: A Systematic Review |
| title_short | Emerging Role of MicroRNAs in the Therapeutic Response in Cervical Cancer: A Systematic Review |
| title_sort | emerging role of micrornas in the therapeutic response in cervical cancer a systematic review |
| topic | cervical cancer miRNAs radiotherapy chemotherapy HPV therapeutic response |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.847974/full |
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