DTI Abnormalities Related to Glioblastoma: A Prospective Comparative Study with Metastasis and Healthy Subjects
(1) Background: Glioblastoma multiforme (GBM) shows complex mechanisms of spreading of the tumor cells, up to remote areas, and little is still known of these mechanisms, thus we focused on MRI abnormalities observable in the tumor and the brain adjacent to the lesion, up to the contralateral hemisp...
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MDPI AG
2022-04-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/29/4/230 |
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| author | Youssef El Ouadih Bruno Pereira Julian Biau Béatrice Claise Rémi Chaix Pierre Verrelle Toufik Khalil Xavier Durando Jean-Jacques Lemaire |
| author_facet | Youssef El Ouadih Bruno Pereira Julian Biau Béatrice Claise Rémi Chaix Pierre Verrelle Toufik Khalil Xavier Durando Jean-Jacques Lemaire |
| author_sort | Youssef El Ouadih |
| collection | DOAJ |
| description | (1) Background: Glioblastoma multiforme (GBM) shows complex mechanisms of spreading of the tumor cells, up to remote areas, and little is still known of these mechanisms, thus we focused on MRI abnormalities observable in the tumor and the brain adjacent to the lesion, up to the contralateral hemisphere, with a special interest on tensor diffusion imaging informing on white matter architecture; (2) Material and Methods: volumes, macroscopic volume (MV), brain-adjacent-tumor (BAT) volume and abnormal color-coded DTI volume (aCCV), and region-of-interest samples (probe volumes, ipsi, and contra lateral to the lesion), with their MRI characteristics, apparent diffusion coefficient (ADC), fractional anisotropy (FA) values, and number of fibers (DTI fiber tracking) were analyzed in patients suffering GBM (<i>n</i> = 15) and metastasis (<i>n</i> = 9), and healthy subjects (<i>n</i> = 15), using ad hoc statistical methods (type I error = 5%) (3) Results: GBM volumes were larger than metastasis volumes, aCCV being larger in GBM and BAT ADC was higher in metastasis, ADC decreased centripetally in metastasis, FA increased centripetally either in GBM or metastasis, MV and BAT FA values were higher in GBM, ipsi FA values of GBM ROIs were higher than those of metastasis, and the GBM ipsi number of fibers was higher than the GBM contra number of fibers; (4) Conclusions: The MV, BAT and especially the aCCV, as well as their related water diffusion characteristics, could be useful biomarkers in oncology and functional oncology. |
| first_indexed | 2024-03-09T10:58:41Z |
| format | Article |
| id | doaj.art-e58449c5d7c44606a31278c1624b7bfe |
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| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T10:58:41Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-e58449c5d7c44606a31278c1624b7bfe2023-12-01T01:27:53ZengMDPI AGCurrent Oncology1198-00521718-77292022-04-012942823283410.3390/curroncol29040230DTI Abnormalities Related to Glioblastoma: A Prospective Comparative Study with Metastasis and Healthy SubjectsYoussef El Ouadih0Bruno Pereira1Julian Biau2Béatrice Claise3Rémi Chaix4Pierre Verrelle5Toufik Khalil6Xavier Durando7Jean-Jacques Lemaire8Service de Neurochirurgie, Institut Pascal, Université Clermont Auvergne, Clermont Auvergne INP, CHU Clermont-Ferrand, CNRS, F-63000 Clermont-Ferrand, FranceDelegation for Clinical Research and Innovation, Université Clermont Auvergne, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, FranceDepartment of Radiation Oncology, Université Clermont Auvergne, Centre Jean Perrin, F-63000 Clermont-Ferrand, FranceService de Neurochirurgie, Institut Pascal, Université Clermont Auvergne, Clermont Auvergne INP, CHU Clermont-Ferrand, CNRS, F-63000 Clermont-Ferrand, FranceService de Neurochirurgie, Institut Pascal, Université Clermont Auvergne, Clermont Auvergne INP, CHU Clermont-Ferrand, CNRS, F-63000 Clermont-Ferrand, FranceDepartment of Radiation Oncology, Université Clermont Auvergne, Centre Jean Perrin, F-63000 Clermont-Ferrand, FranceService de Neurochirurgie, Institut Pascal, Université Clermont Auvergne, Clermont Auvergne INP, CHU Clermont-Ferrand, CNRS, F-63000 Clermont-Ferrand, FranceDepartment of Radiation Oncology, Université Clermont Auvergne, Centre Jean Perrin, F-63000 Clermont-Ferrand, FranceService de Neurochirurgie, Institut Pascal, Université Clermont Auvergne, Clermont Auvergne INP, CHU Clermont-Ferrand, CNRS, F-63000 Clermont-Ferrand, France(1) Background: Glioblastoma multiforme (GBM) shows complex mechanisms of spreading of the tumor cells, up to remote areas, and little is still known of these mechanisms, thus we focused on MRI abnormalities observable in the tumor and the brain adjacent to the lesion, up to the contralateral hemisphere, with a special interest on tensor diffusion imaging informing on white matter architecture; (2) Material and Methods: volumes, macroscopic volume (MV), brain-adjacent-tumor (BAT) volume and abnormal color-coded DTI volume (aCCV), and region-of-interest samples (probe volumes, ipsi, and contra lateral to the lesion), with their MRI characteristics, apparent diffusion coefficient (ADC), fractional anisotropy (FA) values, and number of fibers (DTI fiber tracking) were analyzed in patients suffering GBM (<i>n</i> = 15) and metastasis (<i>n</i> = 9), and healthy subjects (<i>n</i> = 15), using ad hoc statistical methods (type I error = 5%) (3) Results: GBM volumes were larger than metastasis volumes, aCCV being larger in GBM and BAT ADC was higher in metastasis, ADC decreased centripetally in metastasis, FA increased centripetally either in GBM or metastasis, MV and BAT FA values were higher in GBM, ipsi FA values of GBM ROIs were higher than those of metastasis, and the GBM ipsi number of fibers was higher than the GBM contra number of fibers; (4) Conclusions: The MV, BAT and especially the aCCV, as well as their related water diffusion characteristics, could be useful biomarkers in oncology and functional oncology.https://www.mdpi.com/1718-7729/29/4/230glioblastomametastasisinfiltrationMRIDTItractography |
| spellingShingle | Youssef El Ouadih Bruno Pereira Julian Biau Béatrice Claise Rémi Chaix Pierre Verrelle Toufik Khalil Xavier Durando Jean-Jacques Lemaire DTI Abnormalities Related to Glioblastoma: A Prospective Comparative Study with Metastasis and Healthy Subjects Current Oncology glioblastoma metastasis infiltration MRI DTI tractography |
| title | DTI Abnormalities Related to Glioblastoma: A Prospective Comparative Study with Metastasis and Healthy Subjects |
| title_full | DTI Abnormalities Related to Glioblastoma: A Prospective Comparative Study with Metastasis and Healthy Subjects |
| title_fullStr | DTI Abnormalities Related to Glioblastoma: A Prospective Comparative Study with Metastasis and Healthy Subjects |
| title_full_unstemmed | DTI Abnormalities Related to Glioblastoma: A Prospective Comparative Study with Metastasis and Healthy Subjects |
| title_short | DTI Abnormalities Related to Glioblastoma: A Prospective Comparative Study with Metastasis and Healthy Subjects |
| title_sort | dti abnormalities related to glioblastoma a prospective comparative study with metastasis and healthy subjects |
| topic | glioblastoma metastasis infiltration MRI DTI tractography |
| url | https://www.mdpi.com/1718-7729/29/4/230 |
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