Dandelion (Taraxacum officinale) seeds extract attenuates hypercholesterolemia in swiss albino mice
Objectives: The present search aimed to investigate the effect of dandelion seeds extract to reduce hypercholesterolemia and its hazardous effects on liver. Methods: Forty male albino mice were divided into 4 groups, 10 mice per each, the first was the untreated control, the second treated with 400 ...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364722003792 |
| _version_ | 1811266556477308928 |
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| author | Doaa Mohamed El-Nagar Badr Abdullah Al-Dahmash Saad Alkahtani Areej Ahmed Kalu Ahmed Rady |
| author_facet | Doaa Mohamed El-Nagar Badr Abdullah Al-Dahmash Saad Alkahtani Areej Ahmed Kalu Ahmed Rady |
| author_sort | Doaa Mohamed El-Nagar |
| collection | DOAJ |
| description | Objectives: The present search aimed to investigate the effect of dandelion seeds extract to reduce hypercholesterolemia and its hazardous effects on liver. Methods: Forty male albino mice were divided into 4 groups, 10 mice per each, the first was the untreated control, the second treated with 400 mg/kg dandelion seed extract, the third treated with 5 mg/kg of cholesterol powder dissolved in oil and the fourth treated with cholesterol and dandelion extract. Results: It was showed that dandelion seeds extract reduced the weight of the mice. Cholesterol treatment resulted in highly significant increase of liver enzymes activities, total cholesterol, how-density lipoprotein (HDL) and low-density lipoprotein (LDL) of serum besides to pathological changes as steatosis, inflammation, fibrosis and high pathological score in the liver. Dandelion seeds extraction treatment resulted in marked decrease of liver enzymes activities total cholesterol, HDL and LDL of serum, in addition to hepatic tissue improvement with less steatosis, inflammation, fibrosis and lowered pathological score. Conclusion: Dandelion seeds extract could reduce hypercholesterolemia in swiss albino mice. |
| first_indexed | 2024-04-12T20:45:27Z |
| format | Article |
| id | doaj.art-e5871fce7880427abb5dcb41c2745523 |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-04-12T20:45:27Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-e5871fce7880427abb5dcb41c27455232022-12-22T03:17:17ZengElsevierJournal of King Saud University: Science1018-36472022-10-01347102198Dandelion (Taraxacum officinale) seeds extract attenuates hypercholesterolemia in swiss albino miceDoaa Mohamed El-Nagar0Badr Abdullah Al-Dahmash1Saad Alkahtani2Areej Ahmed Kalu3Ahmed Rady4Corresponding author.; Zoology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Kingdom of Saudi ArabiaZoology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Kingdom of Saudi ArabiaZoology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Kingdom of Saudi ArabiaZoology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Kingdom of Saudi ArabiaZoology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Kingdom of Saudi ArabiaObjectives: The present search aimed to investigate the effect of dandelion seeds extract to reduce hypercholesterolemia and its hazardous effects on liver. Methods: Forty male albino mice were divided into 4 groups, 10 mice per each, the first was the untreated control, the second treated with 400 mg/kg dandelion seed extract, the third treated with 5 mg/kg of cholesterol powder dissolved in oil and the fourth treated with cholesterol and dandelion extract. Results: It was showed that dandelion seeds extract reduced the weight of the mice. Cholesterol treatment resulted in highly significant increase of liver enzymes activities, total cholesterol, how-density lipoprotein (HDL) and low-density lipoprotein (LDL) of serum besides to pathological changes as steatosis, inflammation, fibrosis and high pathological score in the liver. Dandelion seeds extraction treatment resulted in marked decrease of liver enzymes activities total cholesterol, HDL and LDL of serum, in addition to hepatic tissue improvement with less steatosis, inflammation, fibrosis and lowered pathological score. Conclusion: Dandelion seeds extract could reduce hypercholesterolemia in swiss albino mice.http://www.sciencedirect.com/science/article/pii/S1018364722003792HypercholesterolemiaDandelionSteatosisInflammation |
| spellingShingle | Doaa Mohamed El-Nagar Badr Abdullah Al-Dahmash Saad Alkahtani Areej Ahmed Kalu Ahmed Rady Dandelion (Taraxacum officinale) seeds extract attenuates hypercholesterolemia in swiss albino mice Journal of King Saud University: Science Hypercholesterolemia Dandelion Steatosis Inflammation |
| title | Dandelion (Taraxacum officinale) seeds extract attenuates hypercholesterolemia in swiss albino mice |
| title_full | Dandelion (Taraxacum officinale) seeds extract attenuates hypercholesterolemia in swiss albino mice |
| title_fullStr | Dandelion (Taraxacum officinale) seeds extract attenuates hypercholesterolemia in swiss albino mice |
| title_full_unstemmed | Dandelion (Taraxacum officinale) seeds extract attenuates hypercholesterolemia in swiss albino mice |
| title_short | Dandelion (Taraxacum officinale) seeds extract attenuates hypercholesterolemia in swiss albino mice |
| title_sort | dandelion taraxacum officinale seeds extract attenuates hypercholesterolemia in swiss albino mice |
| topic | Hypercholesterolemia Dandelion Steatosis Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S1018364722003792 |
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