The Cancer SENESCopedia: A delineation of cancer cell senescence
Summary: Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells. However, senescence features may be different in cancer cells, since the pathways that are involv...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124721008585 |
| _version_ | 1818619135943245824 |
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| author | Fleur Jochems Bram Thijssen Giulia De Conti Robin Jansen Ziva Pogacar Kelvin Groot Liqin Wang Arnout Schepers Cun Wang Haojie Jin Roderick L. Beijersbergen Rodrigo Leite de Oliveira Lodewyk F.A. Wessels René Bernards |
| author_facet | Fleur Jochems Bram Thijssen Giulia De Conti Robin Jansen Ziva Pogacar Kelvin Groot Liqin Wang Arnout Schepers Cun Wang Haojie Jin Roderick L. Beijersbergen Rodrigo Leite de Oliveira Lodewyk F.A. Wessels René Bernards |
| author_sort | Fleur Jochems |
| collection | DOAJ |
| description | Summary: Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells. However, senescence features may be different in cancer cells, since the pathways that are involved in senescence induction are often deregulated in cancer. We report here a comprehensive analysis of the transcriptome and senolytic responses in a panel of 13 cancer cell lines rendered senescent by two distinct compounds. We show that in cancer cells, the response to senolytic agents and the composition of the senescence-associated secretory phenotype are more influenced by the cell of origin than by the senescence trigger. Using machine learning, we establish the SENCAN gene expression classifier for the detection of senescence in cancer cell samples. The expression profiles and senescence classifier are available as an interactive online Cancer SENESCopedia. |
| first_indexed | 2024-12-16T17:32:41Z |
| format | Article |
| id | doaj.art-e5885b546531426bb7c25ec795372518 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-16T17:32:41Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-e5885b546531426bb7c25ec7953725182022-12-21T22:22:54ZengElsevierCell Reports2211-12472021-07-01364109441The Cancer SENESCopedia: A delineation of cancer cell senescenceFleur Jochems0Bram Thijssen1Giulia De Conti2Robin Jansen3Ziva Pogacar4Kelvin Groot5Liqin Wang6Arnout Schepers7Cun Wang8Haojie Jin9Roderick L. Beijersbergen10Rodrigo Leite de Oliveira11Lodewyk F.A. Wessels12René Bernards13Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the NetherlandsDivision of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the NetherlandsDivision of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the NetherlandsDivision of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the NetherlandsDivision of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the NetherlandsDivision of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the NetherlandsDivision of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the NetherlandsDivision of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the NetherlandsDivision of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the NetherlandsDivision of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the NetherlandsDivision of Molecular Carcinogenesis, The NKI Robotics and Screening Center, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the NetherlandsDivision of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the NetherlandsDivision of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands; Faculty of EEMCS, Delft University of Technology, Delft, the Netherlands; Corresponding authorDivision of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Plesmanlaan 121, 1066 Amsterdam, the Netherlands; Corresponding authorSummary: Cellular senescence is characterized as a stable proliferation arrest that can be triggered by multiple stresses. Most knowledge about senescent cells is obtained from studies in primary cells. However, senescence features may be different in cancer cells, since the pathways that are involved in senescence induction are often deregulated in cancer. We report here a comprehensive analysis of the transcriptome and senolytic responses in a panel of 13 cancer cell lines rendered senescent by two distinct compounds. We show that in cancer cells, the response to senolytic agents and the composition of the senescence-associated secretory phenotype are more influenced by the cell of origin than by the senescence trigger. Using machine learning, we establish the SENCAN gene expression classifier for the detection of senescence in cancer cell samples. The expression profiles and senescence classifier are available as an interactive online Cancer SENESCopedia.http://www.sciencedirect.com/science/article/pii/S2211124721008585senescencecancerABT-263gene expression classifiertranscriptome profilingsenolytics |
| spellingShingle | Fleur Jochems Bram Thijssen Giulia De Conti Robin Jansen Ziva Pogacar Kelvin Groot Liqin Wang Arnout Schepers Cun Wang Haojie Jin Roderick L. Beijersbergen Rodrigo Leite de Oliveira Lodewyk F.A. Wessels René Bernards The Cancer SENESCopedia: A delineation of cancer cell senescence Cell Reports senescence cancer ABT-263 gene expression classifier transcriptome profiling senolytics |
| title | The Cancer SENESCopedia: A delineation of cancer cell senescence |
| title_full | The Cancer SENESCopedia: A delineation of cancer cell senescence |
| title_fullStr | The Cancer SENESCopedia: A delineation of cancer cell senescence |
| title_full_unstemmed | The Cancer SENESCopedia: A delineation of cancer cell senescence |
| title_short | The Cancer SENESCopedia: A delineation of cancer cell senescence |
| title_sort | cancer senescopedia a delineation of cancer cell senescence |
| topic | senescence cancer ABT-263 gene expression classifier transcriptome profiling senolytics |
| url | http://www.sciencedirect.com/science/article/pii/S2211124721008585 |
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