Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient
Abstract: Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, by contrast, is characterized by two autoantibodies (anti-desmoglein 1 and 3). Coexistence of autoantibodies of bullous pemphigoid and pemphigus in a patient...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2017-01-01
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| Series: | Anais Brasileiros de Dermatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962017001100034&tlng=en |
| _version_ | 1818732314996244480 |
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| author | Shu Ding Qiancheng Deng Yaping Xiang Jing Chen Jinhua Huang Jianyun Lu |
| author_facet | Shu Ding Qiancheng Deng Yaping Xiang Jing Chen Jinhua Huang Jianyun Lu |
| author_sort | Shu Ding |
| collection | DOAJ |
| description | Abstract: Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, by contrast, is characterized by two autoantibodies (anti-desmoglein 1 and 3). Coexistence of autoantibodies of bullous pemphigoid and pemphigus in a patient is rare. A 25-year-old male patient was admitted to our hospital, reporting a 3-month history of multiple papules, vesicles, and erosions over an extensive erythema on the entire body. Laboratory tests showed high levels of serum IgE, anti-BP180 antibodies, and anti-desmoglein 1 and 3. Histopathologic and immunopathologic features were characterized by bullous pemphigoid. No improvement was seen with systemic corticosteroid therapy, however, pulse corticosteriod therapy combined with methylprednisolone, immunosuppressants, immunomodulators, and plasmapheresis led to the recovery of his condition with numerous milia. |
| first_indexed | 2024-12-17T23:31:37Z |
| format | Article |
| id | doaj.art-e588a93d23484953978a8c04e3722823 |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-12-17T23:31:37Z |
| publishDate | 2017-01-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-e588a93d23484953978a8c04e37228232022-12-21T21:28:39ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962017-01-01925 suppl 1343610.1590/abd1806-4841.20176124Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patientShu DingQiancheng DengYaping XiangJing ChenJinhua HuangJianyun LuAbstract: Bullous pemphigoid is a blistering autoimmune disease characterized by two hemidesmosomal proteins (anti-BP180 and 230). Pemphigus, by contrast, is characterized by two autoantibodies (anti-desmoglein 1 and 3). Coexistence of autoantibodies of bullous pemphigoid and pemphigus in a patient is rare. A 25-year-old male patient was admitted to our hospital, reporting a 3-month history of multiple papules, vesicles, and erosions over an extensive erythema on the entire body. Laboratory tests showed high levels of serum IgE, anti-BP180 antibodies, and anti-desmoglein 1 and 3. Histopathologic and immunopathologic features were characterized by bullous pemphigoid. No improvement was seen with systemic corticosteroid therapy, however, pulse corticosteriod therapy combined with methylprednisolone, immunosuppressants, immunomodulators, and plasmapheresis led to the recovery of his condition with numerous milia.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962017001100034&tlng=enDesmoglein 1MiliariaPemphigoid, bullousPemphigus |
| spellingShingle | Shu Ding Qiancheng Deng Yaping Xiang Jing Chen Jinhua Huang Jianyun Lu Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient Anais Brasileiros de Dermatologia Desmoglein 1 Miliaria Pemphigoid, bullous Pemphigus |
| title | Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient |
| title_full | Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient |
| title_fullStr | Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient |
| title_full_unstemmed | Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient |
| title_short | Bullous pemphigoid associated with milia, increased serum IgE, autoantibodies against desmogleins, and refractory treatment in a young patient |
| title_sort | bullous pemphigoid associated with milia increased serum ige autoantibodies against desmogleins and refractory treatment in a young patient |
| topic | Desmoglein 1 Miliaria Pemphigoid, bullous Pemphigus |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962017001100034&tlng=en |
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