Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
Pancreatic beta-cell glucose metabolism is coupled to insulin secretion. Here the authors set out to characterize changes in beta-cell metabolism in hyperglycemia which may contribute to insufficient insulin secretion in type 2 diabetes and, using a multi-omics approach, find that mitochondrial meta...
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Bibliographic Details
| Main Authors: |
Elizabeth Haythorne,
Maria Rohm,
Martijn van de Bunt,
Melissa F. Brereton,
Andrei I. Tarasov,
Thomas S. Blacker,
Gregor Sachse,
Mariana Silva dos Santos,
Raul Terron Exposito,
Simon Davis,
Otto Baba,
Roman Fischer,
Michael R. Duchen,
Patrik Rorsman,
James I. MacRae,
Frances M. Ashcroft |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2019-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-019-10189-x
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