The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment
Stress-associated disruptions in the development of frontolimbic regions may play a critical role in the emergence of adolescent-onset depression. These regions are particularly sensitive to Hypothalamic-Pituitary-Adrenal (HPA) axis signaling. The HPA axis is hyperactive in adolescent depression, an...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
|
| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354622001314 |
| _version_ | 1797991316445986816 |
|---|---|
| author | Daniel Freimer Tony T. Yang Tiffany C. Ho Olga Tymofiyeva Cherry Leung |
| author_facet | Daniel Freimer Tony T. Yang Tiffany C. Ho Olga Tymofiyeva Cherry Leung |
| author_sort | Daniel Freimer |
| collection | DOAJ |
| description | Stress-associated disruptions in the development of frontolimbic regions may play a critical role in the emergence of adolescent-onset depression. These regions are particularly sensitive to Hypothalamic-Pituitary-Adrenal (HPA) axis signaling. The HPA axis is hyperactive in adolescent depression, and interventions that attenuate such hyperactivity hold promise as potential treatments. The Microbiome-Gut-Brain (MGB) axis is an important pathway through which stress dysregulates HPA-axis activity and thus exerts deleterious effects on the adolescent brain. Probiotic agents, which alter the gut microbiota composition by introducing bacterial strains with beneficial physiological effects, normalize aberrant HPA-axis activity and reduce depressive symptoms in both animal studies and adult clinical trials. While the potential utility of such agents in treating or preventing adolescent depression remains largely unexplored, recent data suggest the existence of an adolescent sensitive window during which probiotics may be especially efficacious in reducing depressive symptoms compared to effects observed in adult populations. In this review, we outline evidence that probiotic use may attenuate stress effects on frontolimbic development, providing a novel means of improving depressive symptoms among adolescent populations. |
| first_indexed | 2024-04-11T08:50:07Z |
| format | Article |
| id | doaj.art-e58eaadfad77494a84f7502a587d2bfb |
| institution | Directory Open Access Journal |
| issn | 2666-3546 |
| language | English |
| last_indexed | 2024-04-11T08:50:07Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain, Behavior, & Immunity - Health |
| spelling | doaj.art-e58eaadfad77494a84f7502a587d2bfb2022-12-22T04:33:47ZengElsevierBrain, Behavior, & Immunity - Health2666-35462022-12-0126100541The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatmentDaniel Freimer0Tony T. Yang1Tiffany C. Ho2Olga Tymofiyeva3Cherry Leung4University of California, San Francisco (UCSF), School of Medicine, USA; Corresponding author.University of California, San Francisco (UCSF), School of Medicine, USA; Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, USA; Division of Child and Adolescent Psychiatry, USA; The Langley Porter Psychiatric Institute, USAUniversity of California, San Francisco (UCSF), School of Medicine, USA; Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, USAUniversity of California, San Francisco (UCSF), School of Medicine, USA; Department of Radiology and Biomedical Imaging, USAUniversity of California, San Francisco (UCSF), School of Nursing, Department of Community Health Systems, USAStress-associated disruptions in the development of frontolimbic regions may play a critical role in the emergence of adolescent-onset depression. These regions are particularly sensitive to Hypothalamic-Pituitary-Adrenal (HPA) axis signaling. The HPA axis is hyperactive in adolescent depression, and interventions that attenuate such hyperactivity hold promise as potential treatments. The Microbiome-Gut-Brain (MGB) axis is an important pathway through which stress dysregulates HPA-axis activity and thus exerts deleterious effects on the adolescent brain. Probiotic agents, which alter the gut microbiota composition by introducing bacterial strains with beneficial physiological effects, normalize aberrant HPA-axis activity and reduce depressive symptoms in both animal studies and adult clinical trials. While the potential utility of such agents in treating or preventing adolescent depression remains largely unexplored, recent data suggest the existence of an adolescent sensitive window during which probiotics may be especially efficacious in reducing depressive symptoms compared to effects observed in adult populations. In this review, we outline evidence that probiotic use may attenuate stress effects on frontolimbic development, providing a novel means of improving depressive symptoms among adolescent populations.http://www.sciencedirect.com/science/article/pii/S2666354622001314AdolescentDepressionStressHPA axisNeurodevelopmentMicrobiota |
| spellingShingle | Daniel Freimer Tony T. Yang Tiffany C. Ho Olga Tymofiyeva Cherry Leung The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment Brain, Behavior, & Immunity - Health Adolescent Depression Stress HPA axis Neurodevelopment Microbiota |
| title | The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment |
| title_full | The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment |
| title_fullStr | The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment |
| title_full_unstemmed | The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment |
| title_short | The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment |
| title_sort | gut microbiota hpa axis and brain in adolescent onset depression probiotics as a novel treatment |
| topic | Adolescent Depression Stress HPA axis Neurodevelopment Microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S2666354622001314 |
| work_keys_str_mv | AT danielfreimer thegutmicrobiotahpaaxisandbraininadolescentonsetdepressionprobioticsasanoveltreatment AT tonytyang thegutmicrobiotahpaaxisandbraininadolescentonsetdepressionprobioticsasanoveltreatment AT tiffanycho thegutmicrobiotahpaaxisandbraininadolescentonsetdepressionprobioticsasanoveltreatment AT olgatymofiyeva thegutmicrobiotahpaaxisandbraininadolescentonsetdepressionprobioticsasanoveltreatment AT cherryleung thegutmicrobiotahpaaxisandbraininadolescentonsetdepressionprobioticsasanoveltreatment AT danielfreimer gutmicrobiotahpaaxisandbraininadolescentonsetdepressionprobioticsasanoveltreatment AT tonytyang gutmicrobiotahpaaxisandbraininadolescentonsetdepressionprobioticsasanoveltreatment AT tiffanycho gutmicrobiotahpaaxisandbraininadolescentonsetdepressionprobioticsasanoveltreatment AT olgatymofiyeva gutmicrobiotahpaaxisandbraininadolescentonsetdepressionprobioticsasanoveltreatment AT cherryleung gutmicrobiotahpaaxisandbraininadolescentonsetdepressionprobioticsasanoveltreatment |