Biomarkers for Sepsis: What is and What Might Be?
Every year numerous individuals develop the morbid condition of sepsis. Therefore, novel biomarkers that might better inform clinicians treating such patients are sorely needed. Difficulty in identifying such markers is in part due to the complex heterogeneity of sepsis, resulting from the broad and...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2015-01-01
|
| Series: | Biomarker Insights |
| Online Access: | https://doi.org/10.4137/BMI.S29519 |
| _version_ | 1828453328060678144 |
|---|---|
| author | Bethany M. Biron Alfred Ayala Joanne L. Lomas-Neira |
| author_facet | Bethany M. Biron Alfred Ayala Joanne L. Lomas-Neira |
| author_sort | Bethany M. Biron |
| collection | DOAJ |
| description | Every year numerous individuals develop the morbid condition of sepsis. Therefore, novel biomarkers that might better inform clinicians treating such patients are sorely needed. Difficulty in identifying such markers is in part due to the complex heterogeneity of sepsis, resulting from the broad and vague definition of this state/condition based on numerous possible clinical signs and symptoms as well as an incomplete understanding of the underlying pathobiology of this complex condition. This review considers some of the attempts that have been made so far, looking at both the pro- and anti-inflammatory response to sepsis, as well as genomic analysis, as sources of potential biomarkers. Irrespective, for functional biomarker(s) of sepsis to successfully translate from the laboratory to a clinical setting, the biomarker must be target specific and sensitive as well as easy to implement/interpret, and be cost effective, such that they can be utilized routinely in patient diagnosis and treatment. |
| first_indexed | 2024-12-11T00:06:29Z |
| format | Article |
| id | doaj.art-e58f098101c34071878fc5248e31bb79 |
| institution | Directory Open Access Journal |
| issn | 1177-2719 |
| language | English |
| last_indexed | 2024-12-11T00:06:29Z |
| publishDate | 2015-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Biomarker Insights |
| spelling | doaj.art-e58f098101c34071878fc5248e31bb792022-12-22T01:28:19ZengSAGE PublishingBiomarker Insights1177-27192015-01-0110s410.4137/BMI.S29519Biomarkers for Sepsis: What is and What Might Be?Bethany M. Biron0Alfred Ayala1Joanne L. Lomas-Neira2Division of Surgical Research, Department of Surgery, The Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI, USA.Division of Surgical Research, Department of Surgery, The Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI, USA.Division of Surgical Research, Department of Surgery, The Warren Alpert Medical School of Brown University/Rhode Island Hospital, Providence, RI, USA.Every year numerous individuals develop the morbid condition of sepsis. Therefore, novel biomarkers that might better inform clinicians treating such patients are sorely needed. Difficulty in identifying such markers is in part due to the complex heterogeneity of sepsis, resulting from the broad and vague definition of this state/condition based on numerous possible clinical signs and symptoms as well as an incomplete understanding of the underlying pathobiology of this complex condition. This review considers some of the attempts that have been made so far, looking at both the pro- and anti-inflammatory response to sepsis, as well as genomic analysis, as sources of potential biomarkers. Irrespective, for functional biomarker(s) of sepsis to successfully translate from the laboratory to a clinical setting, the biomarker must be target specific and sensitive as well as easy to implement/interpret, and be cost effective, such that they can be utilized routinely in patient diagnosis and treatment.https://doi.org/10.4137/BMI.S29519 |
| spellingShingle | Bethany M. Biron Alfred Ayala Joanne L. Lomas-Neira Biomarkers for Sepsis: What is and What Might Be? Biomarker Insights |
| title | Biomarkers for Sepsis: What is and What Might Be? |
| title_full | Biomarkers for Sepsis: What is and What Might Be? |
| title_fullStr | Biomarkers for Sepsis: What is and What Might Be? |
| title_full_unstemmed | Biomarkers for Sepsis: What is and What Might Be? |
| title_short | Biomarkers for Sepsis: What is and What Might Be? |
| title_sort | biomarkers for sepsis what is and what might be |
| url | https://doi.org/10.4137/BMI.S29519 |
| work_keys_str_mv | AT bethanymbiron biomarkersforsepsiswhatisandwhatmightbe AT alfredayala biomarkersforsepsiswhatisandwhatmightbe AT joannellomasneira biomarkersforsepsiswhatisandwhatmightbe |