Pilot study on gut microbiota profile in Indian children with type 1 diabetes
Background: Non-genetic factors like microbial dysbiosis may be contributing to the increasing incidence/progression of type 1 diabetes mellitus (T1DM). Objectives: To analyse the gut microbiota profile in Indian children with T1DM and its effect on glycaemic control. Methodology: Faecal samples of...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=5;spage=404;epage=409;aulast=Shah |
| _version_ | 1827269813910634496 |
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| author | Nikhil Shah Abhijit Kulkarni Dattatray Mongad Kunal Jaani Neha Kajale Vaishali Tamahane Shital Bhor Dipali Ladkat Vaman Khadilkar Ketan Gondhalekar Yogesh Shouche Anuradha V Khadilkar |
| author_facet | Nikhil Shah Abhijit Kulkarni Dattatray Mongad Kunal Jaani Neha Kajale Vaishali Tamahane Shital Bhor Dipali Ladkat Vaman Khadilkar Ketan Gondhalekar Yogesh Shouche Anuradha V Khadilkar |
| author_sort | Nikhil Shah |
| collection | DOAJ |
| description | Background: Non-genetic factors like microbial dysbiosis may be contributing to the increasing incidence/progression of type 1 diabetes mellitus (T1DM). Objectives: To analyse the gut microbiota profile in Indian children with T1DM and its effect on glycaemic control. Methodology: Faecal samples of 29 children with T1DM were collected and faecal microbial DNA was extracted and subjected to 16S rRNA (ribosomal RNA) sequencing and further analysis. Results: The dominant phyla in children with T1DM were Firmicutes and Bacteroidetes. Butyrate-producing bacteria Blautia and Ruminococcus showed a significant negative correlation with the glycosylated haemoglobin (HbA1C) levels (p < 0.05). Coprococcus and Propionibacterium were important negative predictors of glycaemic control (p < 0.05). Conclusion: Our study suggests that Indian children with T1DM have a distinct gut microbiome taxonomic composition and that short-chain fatty acid-producing bacteria like Ruminococcus and Blautia (butyrate-producing) may play an important role in the glycaemic control of subjects with T1DM. |
| first_indexed | 2024-03-07T21:36:04Z |
| format | Article |
| id | doaj.art-e59013b4ac4e45f89f5a82d0491bd606 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 |
| language | English |
| last_indexed | 2025-03-22T05:11:30Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-e59013b4ac4e45f89f5a82d0491bd6062024-04-27T06:30:15ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102023-01-0127540440910.4103/ijem.ijem_22_22Pilot study on gut microbiota profile in Indian children with type 1 diabetesNikhil ShahAbhijit KulkarniDattatray MongadKunal JaaniNeha KajaleVaishali TamahaneShital BhorDipali LadkatVaman KhadilkarKetan GondhalekarYogesh ShoucheAnuradha V KhadilkarBackground: Non-genetic factors like microbial dysbiosis may be contributing to the increasing incidence/progression of type 1 diabetes mellitus (T1DM). Objectives: To analyse the gut microbiota profile in Indian children with T1DM and its effect on glycaemic control. Methodology: Faecal samples of 29 children with T1DM were collected and faecal microbial DNA was extracted and subjected to 16S rRNA (ribosomal RNA) sequencing and further analysis. Results: The dominant phyla in children with T1DM were Firmicutes and Bacteroidetes. Butyrate-producing bacteria Blautia and Ruminococcus showed a significant negative correlation with the glycosylated haemoglobin (HbA1C) levels (p < 0.05). Coprococcus and Propionibacterium were important negative predictors of glycaemic control (p < 0.05). Conclusion: Our study suggests that Indian children with T1DM have a distinct gut microbiome taxonomic composition and that short-chain fatty acid-producing bacteria like Ruminococcus and Blautia (butyrate-producing) may play an important role in the glycaemic control of subjects with T1DM.http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=5;spage=404;epage=409;aulast=Shahchildrenglycaemic controlindiamicrobiotascfashort-chain fatty acidstype 1 diabetes |
| spellingShingle | Nikhil Shah Abhijit Kulkarni Dattatray Mongad Kunal Jaani Neha Kajale Vaishali Tamahane Shital Bhor Dipali Ladkat Vaman Khadilkar Ketan Gondhalekar Yogesh Shouche Anuradha V Khadilkar Pilot study on gut microbiota profile in Indian children with type 1 diabetes Indian Journal of Endocrinology and Metabolism children glycaemic control india microbiota scfa short-chain fatty acids type 1 diabetes |
| title | Pilot study on gut microbiota profile in Indian children with type 1 diabetes |
| title_full | Pilot study on gut microbiota profile in Indian children with type 1 diabetes |
| title_fullStr | Pilot study on gut microbiota profile in Indian children with type 1 diabetes |
| title_full_unstemmed | Pilot study on gut microbiota profile in Indian children with type 1 diabetes |
| title_short | Pilot study on gut microbiota profile in Indian children with type 1 diabetes |
| title_sort | pilot study on gut microbiota profile in indian children with type 1 diabetes |
| topic | children glycaemic control india microbiota scfa short-chain fatty acids type 1 diabetes |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2023;volume=27;issue=5;spage=404;epage=409;aulast=Shah |
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