Controlled Synthesis and Characterization of Micrometric Single Crystalline Magnetite With Superparamagnetic Behavior and Cytocompatibility/Cytotoxicity Assessments
A new class of magnetite (Fe3O4) particles, coined as “Single Crystalline Micrometric Iron Oxide Particles” (SCMIOPs), were obtained by hydrothermal synthesis. Both the single Fe3O4 phase content and the particle sizes range, from 1 µm to 30 µm, can be controlled by synthesis. The notable finding st...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphar.2020.00410/full |
| _version_ | 1811206557117972480 |
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| author | Claudia Geanina Farcas Claudia Geanina Farcas Ioana Macasoi Iulia Pinzaru Marius Chirita Marius Constantin Chirita Mihaila Marius Constantin Chirita Mihaila Marius Constantin Chirita Mihaila Cristina Dehelean Stefana Avram Felicia Loghin Liviu Mocanu Virgil Rotaru Adrian Ieta Aurel Ercuta Dorina Coricovac |
| author_facet | Claudia Geanina Farcas Claudia Geanina Farcas Ioana Macasoi Iulia Pinzaru Marius Chirita Marius Constantin Chirita Mihaila Marius Constantin Chirita Mihaila Marius Constantin Chirita Mihaila Cristina Dehelean Stefana Avram Felicia Loghin Liviu Mocanu Virgil Rotaru Adrian Ieta Aurel Ercuta Dorina Coricovac |
| author_sort | Claudia Geanina Farcas |
| collection | DOAJ |
| description | A new class of magnetite (Fe3O4) particles, coined as “Single Crystalline Micrometric Iron Oxide Particles” (SCMIOPs), were obtained by hydrothermal synthesis. Both the single Fe3O4 phase content and the particle sizes range, from 1 µm to 30 µm, can be controlled by synthesis. The notable finding states that these particles exhibit vanishing remanent magnetization (σr=0.28 emu/g) and coercive force (Hc=1.5 Oe), which indicate a superparamagnetic-like behavior (unexpected at micrometric particles size), and remarkably high saturation magnetization (σs=95.5 emu/g), what ensures strong magnetic response, and the lack of agglomeration after the magnetic field removal. These qualities make such particles candidates for biomedical applications, to be used instead of magnetic nanoparticles which inevitably involve some drawbacks like aglommeration and insufficient magnetic response. In this sense, cytocompatibility/cytotoxicity tests were performed on human cells, and the results have clearly indicated that SCMIOPs are cytocompatible for healthy cell lines HaCaT (human keratinocytes) and HEMa (primary epidermal melanocytes) and cytotoxic for neoplastic cell lines A375 (human melanoma) and B164A5 (murine melanoma) in a dose-dependent manner. |
| first_indexed | 2024-04-12T03:50:13Z |
| format | Article |
| id | doaj.art-e590d6e7ee9e4cfeaa0aaf0597e38636 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T03:50:13Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-e590d6e7ee9e4cfeaa0aaf0597e386362022-12-22T03:49:01ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122020-04-011110.3389/fphar.2020.00410486648Controlled Synthesis and Characterization of Micrometric Single Crystalline Magnetite With Superparamagnetic Behavior and Cytocompatibility/Cytotoxicity AssessmentsClaudia Geanina Farcas0Claudia Geanina Farcas1Ioana Macasoi2Iulia Pinzaru3Marius Chirita4Marius Constantin Chirita Mihaila5Marius Constantin Chirita Mihaila6Marius Constantin Chirita Mihaila7Cristina Dehelean8Stefana Avram9Felicia Loghin10Liviu Mocanu11Virgil Rotaru12Adrian Ieta13Aurel Ercuta14Dorina Coricovac15Department of Toxicology, Faculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaFaculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaFaculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaFaculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaDepartment of Condensed Matter, National Institute for Research and Development in Electrochemistry and Condensed Matter, Timisoara, RomaniaDepartment of Condensed Matter, National Institute for Research and Development in Electrochemistry and Condensed Matter, Timisoara, RomaniaMax F. Prutz Laboratories, Department of Structural and Computational Biology, University of Vienna, Vienna, AustriaQuantum Optics, Quantum Nanophysics and Quantum Information, Faculty of Physics, University of Vienna, Vienna, AustriaFaculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaFaculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaDepartment of Toxicology, Faculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Condensed Matter, National Institute for Research and Development in Electrochemistry and Condensed Matter, Timisoara, RomaniaFaculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaElectrical and Computer Science Department SUNY Oswego, Oswego, NY, United StatesFaculty of Physics, West University of Timisoara, Timisoara, RomaniaFaculty of Pharmacy, “Victor Babes” University of Medicine and Pharmacy, Timisoara, RomaniaA new class of magnetite (Fe3O4) particles, coined as “Single Crystalline Micrometric Iron Oxide Particles” (SCMIOPs), were obtained by hydrothermal synthesis. Both the single Fe3O4 phase content and the particle sizes range, from 1 µm to 30 µm, can be controlled by synthesis. The notable finding states that these particles exhibit vanishing remanent magnetization (σr=0.28 emu/g) and coercive force (Hc=1.5 Oe), which indicate a superparamagnetic-like behavior (unexpected at micrometric particles size), and remarkably high saturation magnetization (σs=95.5 emu/g), what ensures strong magnetic response, and the lack of agglomeration after the magnetic field removal. These qualities make such particles candidates for biomedical applications, to be used instead of magnetic nanoparticles which inevitably involve some drawbacks like aglommeration and insufficient magnetic response. In this sense, cytocompatibility/cytotoxicity tests were performed on human cells, and the results have clearly indicated that SCMIOPs are cytocompatible for healthy cell lines HaCaT (human keratinocytes) and HEMa (primary epidermal melanocytes) and cytotoxic for neoplastic cell lines A375 (human melanoma) and B164A5 (murine melanoma) in a dose-dependent manner.https://www.frontiersin.org/article/10.3389/fphar.2020.00410/fullsingle-crystallinesuperparamagneticmicrometrichealthy/tumor cellsviability |
| spellingShingle | Claudia Geanina Farcas Claudia Geanina Farcas Ioana Macasoi Iulia Pinzaru Marius Chirita Marius Constantin Chirita Mihaila Marius Constantin Chirita Mihaila Marius Constantin Chirita Mihaila Cristina Dehelean Stefana Avram Felicia Loghin Liviu Mocanu Virgil Rotaru Adrian Ieta Aurel Ercuta Dorina Coricovac Controlled Synthesis and Characterization of Micrometric Single Crystalline Magnetite With Superparamagnetic Behavior and Cytocompatibility/Cytotoxicity Assessments Frontiers in Pharmacology single-crystalline superparamagnetic micrometric healthy/tumor cells viability |
| title | Controlled Synthesis and Characterization of Micrometric Single Crystalline Magnetite With Superparamagnetic Behavior and Cytocompatibility/Cytotoxicity Assessments |
| title_full | Controlled Synthesis and Characterization of Micrometric Single Crystalline Magnetite With Superparamagnetic Behavior and Cytocompatibility/Cytotoxicity Assessments |
| title_fullStr | Controlled Synthesis and Characterization of Micrometric Single Crystalline Magnetite With Superparamagnetic Behavior and Cytocompatibility/Cytotoxicity Assessments |
| title_full_unstemmed | Controlled Synthesis and Characterization of Micrometric Single Crystalline Magnetite With Superparamagnetic Behavior and Cytocompatibility/Cytotoxicity Assessments |
| title_short | Controlled Synthesis and Characterization of Micrometric Single Crystalline Magnetite With Superparamagnetic Behavior and Cytocompatibility/Cytotoxicity Assessments |
| title_sort | controlled synthesis and characterization of micrometric single crystalline magnetite with superparamagnetic behavior and cytocompatibility cytotoxicity assessments |
| topic | single-crystalline superparamagnetic micrometric healthy/tumor cells viability |
| url | https://www.frontiersin.org/article/10.3389/fphar.2020.00410/full |
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