The association between vaccine hesitancy and pertussis: a systematic review and meta-analysis
Abstract Background Robust routine immunization schedules for pertussis-containing vaccines have been applied for years, but pertussis outbreaks remain a worldwide problem. This study aimed to investigate the association between vaccine hesitancy and pertussis in infants and children. Methods We sea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Italian Journal of Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13052-023-01495-8 |
| _version_ | 1797778798643511296 |
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| author | Yuning Wang Naiyang Shi Qiang Wang Liuqing Yang Tingting Cui Hui Jin |
| author_facet | Yuning Wang Naiyang Shi Qiang Wang Liuqing Yang Tingting Cui Hui Jin |
| author_sort | Yuning Wang |
| collection | DOAJ |
| description | Abstract Background Robust routine immunization schedules for pertussis-containing vaccines have been applied for years, but pertussis outbreaks remain a worldwide problem. This study aimed to investigate the association between vaccine hesitancy and pertussis in infants and children. Methods We searched PubMed, Cochrane, Web of Science, Embase, and China National Knowledge Internet for studies published between January 2012 and June 2022. This study included case–control and cohort studies that assessed the association between childhood/maternal vaccine hesitancy and odds ratios (ORs), risk ratios (RRs), and vaccine effectiveness (VE) related to pertussis in infants and children $$\le$$ ≤ 9 years old. ORs/VEs with a 95% confidence interval (CI) were calculated. Random-effects meta-analysis models were used for appropriate pooled estimates, and heterogeneity was assessed using $${I}^{2}$$ I 2 . Cumulative meta-analysis and subgroup analyses stratified by study characteristics were performed. Results Twenty-two studies were included, with a mean quality score of 7.0 (range 6.0–9.0). Infants and children with pertussis were associated with higher vaccine hesitancy to all doses (OR = 4.12 [95% CI: 3.09–5.50]). The highest OR was between children who were unvaccinated over four doses and children who were fully vaccinated (OR = 14.26 [95%CI: 7.62–26.70]); childhood vaccine delay was not statistically significantly associated with pertussis risk (OR = 1.18 [95% CI: 0.74–1.89]). Maternal vaccine hesitancy was associated with significantly higher pertussis risk in infants aged 2 and 3 months old, with higher pertussis ORs in infants $$\le$$ ≤ 2 months old (OR = 6.02 [95%CI: 4.31–8.50], OR = 5.14 [95%CI: 1.95–13.52] for infants $$\le$$ ≤ 2 and $$\le$$ ≤ 3 months old, respectively). Maternal and childhood VEs were high in reducing pertussis infection in infants and children. The administration time of maternal vaccination had little effect on VE. Conclusion Vaccine hesitancy increased pertussis risks in infants and children. Ensuring that children receive up-to-date pertussis vaccines is essential; short delays in receiving childhood vaccinations may be unimportant. Maternal vaccinations for pertussis should be encouraged. |
| first_indexed | 2024-03-12T23:22:46Z |
| format | Article |
| id | doaj.art-e591926ad7e44be096f894d2ad8844e5 |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-03-12T23:22:46Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-e591926ad7e44be096f894d2ad8844e52023-07-16T11:23:22ZengBMCItalian Journal of Pediatrics1824-72882023-07-0149111010.1186/s13052-023-01495-8The association between vaccine hesitancy and pertussis: a systematic review and meta-analysisYuning Wang0Naiyang Shi1Qiang Wang2Liuqing Yang3Tingting Cui4Hui Jin5Department of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityAbstract Background Robust routine immunization schedules for pertussis-containing vaccines have been applied for years, but pertussis outbreaks remain a worldwide problem. This study aimed to investigate the association between vaccine hesitancy and pertussis in infants and children. Methods We searched PubMed, Cochrane, Web of Science, Embase, and China National Knowledge Internet for studies published between January 2012 and June 2022. This study included case–control and cohort studies that assessed the association between childhood/maternal vaccine hesitancy and odds ratios (ORs), risk ratios (RRs), and vaccine effectiveness (VE) related to pertussis in infants and children $$\le$$ ≤ 9 years old. ORs/VEs with a 95% confidence interval (CI) were calculated. Random-effects meta-analysis models were used for appropriate pooled estimates, and heterogeneity was assessed using $${I}^{2}$$ I 2 . Cumulative meta-analysis and subgroup analyses stratified by study characteristics were performed. Results Twenty-two studies were included, with a mean quality score of 7.0 (range 6.0–9.0). Infants and children with pertussis were associated with higher vaccine hesitancy to all doses (OR = 4.12 [95% CI: 3.09–5.50]). The highest OR was between children who were unvaccinated over four doses and children who were fully vaccinated (OR = 14.26 [95%CI: 7.62–26.70]); childhood vaccine delay was not statistically significantly associated with pertussis risk (OR = 1.18 [95% CI: 0.74–1.89]). Maternal vaccine hesitancy was associated with significantly higher pertussis risk in infants aged 2 and 3 months old, with higher pertussis ORs in infants $$\le$$ ≤ 2 months old (OR = 6.02 [95%CI: 4.31–8.50], OR = 5.14 [95%CI: 1.95–13.52] for infants $$\le$$ ≤ 2 and $$\le$$ ≤ 3 months old, respectively). Maternal and childhood VEs were high in reducing pertussis infection in infants and children. The administration time of maternal vaccination had little effect on VE. Conclusion Vaccine hesitancy increased pertussis risks in infants and children. Ensuring that children receive up-to-date pertussis vaccines is essential; short delays in receiving childhood vaccinations may be unimportant. Maternal vaccinations for pertussis should be encouraged.https://doi.org/10.1186/s13052-023-01495-8Vaccine hesitancyPertussisVaccine effectivenessChildren |
| spellingShingle | Yuning Wang Naiyang Shi Qiang Wang Liuqing Yang Tingting Cui Hui Jin The association between vaccine hesitancy and pertussis: a systematic review and meta-analysis Italian Journal of Pediatrics Vaccine hesitancy Pertussis Vaccine effectiveness Children |
| title | The association between vaccine hesitancy and pertussis: a systematic review and meta-analysis |
| title_full | The association between vaccine hesitancy and pertussis: a systematic review and meta-analysis |
| title_fullStr | The association between vaccine hesitancy and pertussis: a systematic review and meta-analysis |
| title_full_unstemmed | The association between vaccine hesitancy and pertussis: a systematic review and meta-analysis |
| title_short | The association between vaccine hesitancy and pertussis: a systematic review and meta-analysis |
| title_sort | association between vaccine hesitancy and pertussis a systematic review and meta analysis |
| topic | Vaccine hesitancy Pertussis Vaccine effectiveness Children |
| url | https://doi.org/10.1186/s13052-023-01495-8 |
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