Prolonged Alprazolam Treatment Alters Components of Glutamatergic Neurotransmission in the Hippocampus of Male Wistar Rats—The Neuroadaptive Changes following Long-Term Benzodiazepine (Mis)Use

Prolonged Alprazolam Treatment Alters Components of Glutamatergic Neurotransmission in the Hippocampus of Male Wistar Rats—The Neuroadaptive Changes following Long-Term Benzodiazepine (Mis)Use

Alprazolam (ALP), a benzodiazepine (BDZ) used to treat anxiety, panic, and sleep disorders, is one of the most prescribed psychotropic drugs worldwide. The side effects associated with long-term (mis)use of ALP have become a major challenge in pharmacotherapy, emphasizing the unmet need to further i...

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Bibliographic Details
Main Authors: Marina Zaric Kontic, Milorad Dragic, Jelena Martinovic, Katarina Mihajlovic, Zeljka Brkic, Natasa Mitrovic, Ivana Grkovic
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceuticals
Subjects:
Alprazolam
benzodiazepines
hippocampus
<i>N</i>-Methyl-<span style="font-variant: small-caps">d</span>-aspartate receptor
gammaaminobutyric acid receptor type A
excitatory amino acid transporters 1/2
Online Access:https://www.mdpi.com/1424-8247/16/3/331

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