Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study)
Background Apart from nondippers’ impact on cardiovascular events, the prevalence of isolated nocturnal hypertension (INH) and its consequences on both the heart and brain were not clearly investigated in the general population. Methods and Results The participants underwent ambulatory blood pressur...
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| Format: | Article |
| Language: | English |
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Wiley
2022-10-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.025641 |
| _version_ | 1797857455001042944 |
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| author | Seong Hwan Kim Chol Shin Sunwon Kim Jin‐Seok Kim Sang Yup Lim Hyeong‐Seok Seo Hong Euy Lim Ki‐Chul Sung Goo‐Yeong Cho Seung Ku Lee Yong‐Hyun Kim |
| author_facet | Seong Hwan Kim Chol Shin Sunwon Kim Jin‐Seok Kim Sang Yup Lim Hyeong‐Seok Seo Hong Euy Lim Ki‐Chul Sung Goo‐Yeong Cho Seung Ku Lee Yong‐Hyun Kim |
| author_sort | Seong Hwan Kim |
| collection | DOAJ |
| description | Background Apart from nondippers’ impact on cardiovascular events, the prevalence of isolated nocturnal hypertension (INH) and its consequences on both the heart and brain were not clearly investigated in the general population. Methods and Results The participants underwent ambulatory blood pressure monitoring evaluations for arterial stiffness, echocardiography, and brain magnetic resonance imaging. They were grouped into normotension, INH, and overt diurnal hypertension, based on ambulatory blood pressure monitoring and history of antihypertensive treatment. White matter hyperintensity, arterial stiffness, and echocardiographic parameters were compared. Of the 1734 participants, there were 475 (27.4%) subjects with normotension, 314 with INH (18.1%), and 945 with overt diurnal hypertension (54.5%). Prevalence of INH was not different between sex or age. Of INH, 71.3% (n=224) was caused by elevated diastolic blood pressure. After multivariable adjustment, INH showed higher pulse wave velocity (P<0.001) and central systolic blood pressure (P<0.001), left ventricular mass index (P=0.026), and worse left ventricular diastolic function (early diastolic mitral annular velocity) (P<0.001) than normotension. Mean white matter hyperintensity scores of INH were not different from normotension (P=0.321), but the odds for white matter hyperintensity presence were higher in INH than normotension (odds ratio, 1.504 [95% CI, 1.097–2.062]; P=0.011). Conclusions INH was common in the general population and associated with increased arterial stiffness, left ventricular hypertrophy, and diastolic dysfunction. White matter hyperintensity was more likely to be present in the INH group than in the normotension group. The use of ambulatory blood pressure monitoring should be encouraged to identify masked INH and prevent the occurrence of cardiovascular events. |
| first_indexed | 2024-04-09T20:56:58Z |
| format | Article |
| id | doaj.art-e592c122692045749e23a946608f97de |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-09T20:56:58Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-e592c122692045749e23a946608f97de2023-03-29T18:35:57ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-10-01111910.1161/JAHA.122.025641Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study)Seong Hwan Kim0Chol Shin1Sunwon Kim2Jin‐Seok Kim3Sang Yup Lim4Hyeong‐Seok Seo5Hong Euy Lim6Ki‐Chul Sung7Goo‐Yeong Cho8Seung Ku Lee9Yong‐Hyun Kim10Division of Cardiology, Department of Internal Medicine Korea University Ansan Hospital Ansan Republic of KoreaInstitute of Human Genomic Study, Department of Radiology Korea University Ansan Hospital Ansan Republic of KoreaDivision of Cardiology, Department of Internal Medicine Korea University Ansan Hospital Ansan Republic of KoreaDivision of Cardiology, Department of Internal Medicine Korea University Ansan Hospital Ansan Republic of KoreaDivision of Cardiology, Department of Internal Medicine Korea University Ansan Hospital Ansan Republic of KoreaInstitute of Human Genomic Study, Department of Radiology Korea University Ansan Hospital Ansan Republic of KoreaDivision of Cardiology, Department of Internal Medicine Hallym University Sacred Heart Hospital Anyang Republic of KoreaDivision of Cardiology, Department of Internal Medicine Kangbuk Samsung Medical Center Seoul Republic of KoreaDivision of Cardiology, Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Republic of KoreaInstitute of Human Genomic Study, Department of Radiology Korea University Ansan Hospital Ansan Republic of KoreaDivision of Cardiology, Department of Internal Medicine Korea University Ansan Hospital Ansan Republic of KoreaBackground Apart from nondippers’ impact on cardiovascular events, the prevalence of isolated nocturnal hypertension (INH) and its consequences on both the heart and brain were not clearly investigated in the general population. Methods and Results The participants underwent ambulatory blood pressure monitoring evaluations for arterial stiffness, echocardiography, and brain magnetic resonance imaging. They were grouped into normotension, INH, and overt diurnal hypertension, based on ambulatory blood pressure monitoring and history of antihypertensive treatment. White matter hyperintensity, arterial stiffness, and echocardiographic parameters were compared. Of the 1734 participants, there were 475 (27.4%) subjects with normotension, 314 with INH (18.1%), and 945 with overt diurnal hypertension (54.5%). Prevalence of INH was not different between sex or age. Of INH, 71.3% (n=224) was caused by elevated diastolic blood pressure. After multivariable adjustment, INH showed higher pulse wave velocity (P<0.001) and central systolic blood pressure (P<0.001), left ventricular mass index (P=0.026), and worse left ventricular diastolic function (early diastolic mitral annular velocity) (P<0.001) than normotension. Mean white matter hyperintensity scores of INH were not different from normotension (P=0.321), but the odds for white matter hyperintensity presence were higher in INH than normotension (odds ratio, 1.504 [95% CI, 1.097–2.062]; P=0.011). Conclusions INH was common in the general population and associated with increased arterial stiffness, left ventricular hypertrophy, and diastolic dysfunction. White matter hyperintensity was more likely to be present in the INH group than in the normotension group. The use of ambulatory blood pressure monitoring should be encouraged to identify masked INH and prevent the occurrence of cardiovascular events.https://www.ahajournals.org/doi/10.1161/JAHA.122.025641ambulatory blood pressurenocturnal hypertensiontarget organ damagewhite matter hyperintensity |
| spellingShingle | Seong Hwan Kim Chol Shin Sunwon Kim Jin‐Seok Kim Sang Yup Lim Hyeong‐Seok Seo Hong Euy Lim Ki‐Chul Sung Goo‐Yeong Cho Seung Ku Lee Yong‐Hyun Kim Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study) Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease ambulatory blood pressure nocturnal hypertension target organ damage white matter hyperintensity |
| title | Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study) |
| title_full | Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study) |
| title_fullStr | Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study) |
| title_full_unstemmed | Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study) |
| title_short | Prevalence of Isolated Nocturnal Hypertension and Development of Arterial Stiffness, Left Ventricular Hypertrophy, and Silent Cerebrovascular Lesions: The KoGES (Korean Genome and Epidemiology Study) |
| title_sort | prevalence of isolated nocturnal hypertension and development of arterial stiffness left ventricular hypertrophy and silent cerebrovascular lesions the koges korean genome and epidemiology study |
| topic | ambulatory blood pressure nocturnal hypertension target organ damage white matter hyperintensity |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.025641 |
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