TSPO is a potential independent prognostic factor associated with cellular respiration and p16 in head and neck squamous cell carcinoma
BackgroundTreatment resistance and relapse are common problems in head and neck squamous cell carcinoma (HNSCC). Except for p16, no clinically accepted prognostic biomarkers are available for HNSCC. New biomarkers predictive of recurrence and survival are crucial for optimal treatment planning and p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1298333/full |
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| author | Sanni Tuominen Sanni Tuominen Sanni Tuominen Sanni Tuominen Linda Nissi Antti Kukkula Antti Kukkula Johannes Routila Teemu Huusko Ilmo Leivo Heikki Minn Heikki Irjala Eliisa Löyttyniemi Sami Ventelä Maria Sundvall Maria Sundvall Maria Sundvall Tove J. Grönroos Tove J. Grönroos Tove J. Grönroos |
| author_facet | Sanni Tuominen Sanni Tuominen Sanni Tuominen Sanni Tuominen Linda Nissi Antti Kukkula Antti Kukkula Johannes Routila Teemu Huusko Ilmo Leivo Heikki Minn Heikki Irjala Eliisa Löyttyniemi Sami Ventelä Maria Sundvall Maria Sundvall Maria Sundvall Tove J. Grönroos Tove J. Grönroos Tove J. Grönroos |
| author_sort | Sanni Tuominen |
| collection | DOAJ |
| description | BackgroundTreatment resistance and relapse are common problems in head and neck squamous cell carcinoma (HNSCC). Except for p16, no clinically accepted prognostic biomarkers are available for HNSCC. New biomarkers predictive of recurrence and survival are crucial for optimal treatment planning and patient outcome. High translocator protein (TSPO) levels have been associated with poor survival in cancer, but the role of TSPO has not been extensively evaluated in HNSCC.Materials and methodsTSPO expression was determined in a large population-based tissue microarray cohort including 611 patients with HNSCC and evaluated for survival in several clinicopathological subgroups. A TCGA HNSCC cohort was used to further analyze the role of TSPO in HNSCC.ResultsTSPO expression was downregulated in more aggressive tumors. Low TSPO expression associated with worse 5-year survival and was an independent prognostic factor for disease-specific survival. Subgroup analyses showed that low TSPO expression associated with worse survival particularly in p16-positive oropharyngeal cancer. In silico analyses supported the prognostic role of TSPO. Cellular respiration had the highest significance in pathway analyses for genes expressed positively with TSPO.ConclusionDecreased TSPO expression associates with poor prognosis in HNSCC. TSPO is a prognostic biomarker in HNSCC to potentially guide treatment stratification especially in p16-positive oropharyngeal cancer. |
| first_indexed | 2024-03-08T23:29:18Z |
| format | Article |
| id | doaj.art-e593201e187a47768d76a1ee1ab78441 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T23:29:18Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e593201e187a47768d76a1ee1ab784412023-12-14T16:48:28ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-12-011310.3389/fonc.2023.12983331298333TSPO is a potential independent prognostic factor associated with cellular respiration and p16 in head and neck squamous cell carcinomaSanni Tuominen0Sanni Tuominen1Sanni Tuominen2Sanni Tuominen3Linda Nissi4Antti Kukkula5Antti Kukkula6Johannes Routila7Teemu Huusko8Ilmo Leivo9Heikki Minn10Heikki Irjala11Eliisa Löyttyniemi12Sami Ventelä13Maria Sundvall14Maria Sundvall15Maria Sundvall16Tove J. Grönroos17Tove J. Grönroos18Tove J. Grönroos19Preclinical Imaging Laboratory, Turku PET Centre, University of Turku, Turku, FinlandCancer Research Unit, Institute of Biomedicine, University of Turku, Turku, FinlandFICAN West Cancer Research Laboratory, Turku University Hospital and University of Turku, Turku, FinlandMedicity Research Laboratory, Faculty of Medicine, University of Turku, Turku, FinlandDepartment of Clinical Oncology, Turku University Hospital and University of Turku, Turku, FinlandCancer Research Unit, Institute of Biomedicine, University of Turku, Turku, FinlandFICAN West Cancer Research Laboratory, Turku University Hospital and University of Turku, Turku, FinlandDepartment of Otorhinolaryngology – Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, FinlandDepartment of Otorhinolaryngology – Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, FinlandDepartment of Pathology, Turku University Hospital and University of Turku, Turku, FinlandDepartment of Clinical Oncology, Turku University Hospital and University of Turku, Turku, FinlandDepartment of Otorhinolaryngology – Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, FinlandDepartment of Biostatistics, Turku University Hospital and University of Turku, Turku, FinlandDepartment of Otorhinolaryngology – Head and Neck Surgery, Turku University Hospital and University of Turku, Turku, FinlandCancer Research Unit, Institute of Biomedicine, University of Turku, Turku, FinlandFICAN West Cancer Research Laboratory, Turku University Hospital and University of Turku, Turku, FinlandDepartment of Clinical Oncology, Turku University Hospital and University of Turku, Turku, FinlandPreclinical Imaging Laboratory, Turku PET Centre, University of Turku, Turku, FinlandMedicity Research Laboratory, Faculty of Medicine, University of Turku, Turku, FinlandDepartment of Clinical Oncology, Turku University Hospital and University of Turku, Turku, FinlandBackgroundTreatment resistance and relapse are common problems in head and neck squamous cell carcinoma (HNSCC). Except for p16, no clinically accepted prognostic biomarkers are available for HNSCC. New biomarkers predictive of recurrence and survival are crucial for optimal treatment planning and patient outcome. High translocator protein (TSPO) levels have been associated with poor survival in cancer, but the role of TSPO has not been extensively evaluated in HNSCC.Materials and methodsTSPO expression was determined in a large population-based tissue microarray cohort including 611 patients with HNSCC and evaluated for survival in several clinicopathological subgroups. A TCGA HNSCC cohort was used to further analyze the role of TSPO in HNSCC.ResultsTSPO expression was downregulated in more aggressive tumors. Low TSPO expression associated with worse 5-year survival and was an independent prognostic factor for disease-specific survival. Subgroup analyses showed that low TSPO expression associated with worse survival particularly in p16-positive oropharyngeal cancer. In silico analyses supported the prognostic role of TSPO. Cellular respiration had the highest significance in pathway analyses for genes expressed positively with TSPO.ConclusionDecreased TSPO expression associates with poor prognosis in HNSCC. TSPO is a prognostic biomarker in HNSCC to potentially guide treatment stratification especially in p16-positive oropharyngeal cancer.https://www.frontiersin.org/articles/10.3389/fonc.2023.1298333/fullhead and neck cancerbiomarkerp16translocator proteinoxidative phosphorylationimmune landscape |
| spellingShingle | Sanni Tuominen Sanni Tuominen Sanni Tuominen Sanni Tuominen Linda Nissi Antti Kukkula Antti Kukkula Johannes Routila Teemu Huusko Ilmo Leivo Heikki Minn Heikki Irjala Eliisa Löyttyniemi Sami Ventelä Maria Sundvall Maria Sundvall Maria Sundvall Tove J. Grönroos Tove J. Grönroos Tove J. Grönroos TSPO is a potential independent prognostic factor associated with cellular respiration and p16 in head and neck squamous cell carcinoma Frontiers in Oncology head and neck cancer biomarker p16 translocator protein oxidative phosphorylation immune landscape |
| title | TSPO is a potential independent prognostic factor associated with cellular respiration and p16 in head and neck squamous cell carcinoma |
| title_full | TSPO is a potential independent prognostic factor associated with cellular respiration and p16 in head and neck squamous cell carcinoma |
| title_fullStr | TSPO is a potential independent prognostic factor associated with cellular respiration and p16 in head and neck squamous cell carcinoma |
| title_full_unstemmed | TSPO is a potential independent prognostic factor associated with cellular respiration and p16 in head and neck squamous cell carcinoma |
| title_short | TSPO is a potential independent prognostic factor associated with cellular respiration and p16 in head and neck squamous cell carcinoma |
| title_sort | tspo is a potential independent prognostic factor associated with cellular respiration and p16 in head and neck squamous cell carcinoma |
| topic | head and neck cancer biomarker p16 translocator protein oxidative phosphorylation immune landscape |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1298333/full |
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