Production efficiency of the bacterial non-ribosomal peptide indigoidine relies on the respiratory metabolic state in S. cerevisiae

Production efficiency of the bacterial non-ribosomal peptide indigoidine relies on the respiratory metabolic state in S. cerevisiae

Abstract Background Beyond pathway engineering, the metabolic state of the production host is critical in maintaining the efficiency of cellular production. The biotechnologically important yeast Saccharomyces cerevisiae adjusts its energy metabolism based on the availability of oxygen and carbon so...

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Bibliographic Details
Main Authors: Maren Wehrs, Jan-Philip Prahl, Jadie Moon, Yuchen Li, Deepti Tanjore, Jay D. Keasling, Todd Pray, Aindrila Mukhopadhyay
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Microbial Cell Factories
Subjects:
Non-ribosomal peptide synthetase
NRPS
S. cerevisiae
Indigoidine
Metabolic state
TCA cycle activity
Online Access:http://link.springer.com/article/10.1186/s12934-018-1045-1

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