Anti-metastatic mechanism of mountain cultivated wild ginseng in human cancer cell line
Objective : Ginseng is one of most widely used herbal medicine. Ginseng showed anti-metastasis activities. However, its molecular mechanisms of action are unknown. So we want to report the wild ginseng repress which plays key roles in neoplastic epithelial-mesenchymal transition process. Methods :...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Pharmacopuncture Institute
2010-03-01
|
| Series: | Journal of Pharmacopuncture |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3831/KPI.2010.13.1.037 |
| _version_ | 1811226257063411712 |
|---|---|
| author | Jang SB Lim CS Jang JH Kwon KR |
| author_facet | Jang SB Lim CS Jang JH Kwon KR |
| author_sort | Jang SB |
| collection | DOAJ |
| description | Objective : Ginseng is one of most widely used herbal medicine. Ginseng showed anti-metastasis activities. However, its molecular mechanisms of action are unknown. So we want to report the wild ginseng repress which plays key roles in neoplastic epithelial-mesenchymal transition process.
Methods : Treatment of the human colorectal carcinoma LOVO cells and human gastric carcinoma SNU601 cells with the increased concentrations of cultivated wild ginseng extracts resulted in a gradual decrease in the AXIN2 gene expression.
Results : Metastasis-suppressor genes, maspin and nm23 was not affected by the treatment of ginseng extracts in LOVO cells. Moreover, the mountain cultivated wild ginseng or mountain wild ginseng are similar in their inhibitory effects on the expression of AXIN2 gene, but are substantially stronger than cultivated ginseng.
Conclusion : We described the novel mechanism of wild ginseng-induced anti-metastasis activity by repressing the expression of AXIN2 gene that plays key roles in epithelial-mesenchymal transition process. |
| first_indexed | 2024-04-12T09:22:00Z |
| format | Article |
| id | doaj.art-e59460ccc00847b0b9115ce520f777c3 |
| institution | Directory Open Access Journal |
| issn | 2093-6966 2234-6856 |
| language | English |
| last_indexed | 2024-04-12T09:22:00Z |
| publishDate | 2010-03-01 |
| publisher | Korean Pharmacopuncture Institute |
| record_format | Article |
| series | Journal of Pharmacopuncture |
| spelling | doaj.art-e59460ccc00847b0b9115ce520f777c32022-12-22T03:38:37ZengKorean Pharmacopuncture InstituteJournal of Pharmacopuncture2093-69662234-68562010-03-01131374310.3831/KPI.2010.13.1.037Anti-metastatic mechanism of mountain cultivated wild ginseng in human cancer cell lineJang SB0Lim CS1Jang JH2Kwon KR3College of Oriental medicine, Sangji Univ.College of Oriental medicine, Sangji Univ.Department of Biochemistry, School of Inha Univ.College of Oriental medicine, Sangji Univ.Objective : Ginseng is one of most widely used herbal medicine. Ginseng showed anti-metastasis activities. However, its molecular mechanisms of action are unknown. So we want to report the wild ginseng repress which plays key roles in neoplastic epithelial-mesenchymal transition process. Methods : Treatment of the human colorectal carcinoma LOVO cells and human gastric carcinoma SNU601 cells with the increased concentrations of cultivated wild ginseng extracts resulted in a gradual decrease in the AXIN2 gene expression. Results : Metastasis-suppressor genes, maspin and nm23 was not affected by the treatment of ginseng extracts in LOVO cells. Moreover, the mountain cultivated wild ginseng or mountain wild ginseng are similar in their inhibitory effects on the expression of AXIN2 gene, but are substantially stronger than cultivated ginseng. Conclusion : We described the novel mechanism of wild ginseng-induced anti-metastasis activity by repressing the expression of AXIN2 gene that plays key roles in epithelial-mesenchymal transition process.http://dx.doi.org/10.3831/KPI.2010.13.1.037Ginsengcultivated wild ginsengantimetastasis activitiesAXIN2 gene |
| spellingShingle | Jang SB Lim CS Jang JH Kwon KR Anti-metastatic mechanism of mountain cultivated wild ginseng in human cancer cell line Journal of Pharmacopuncture Ginseng cultivated wild ginseng antimetastasis activities AXIN2 gene |
| title | Anti-metastatic mechanism of mountain cultivated wild ginseng in human cancer cell line |
| title_full | Anti-metastatic mechanism of mountain cultivated wild ginseng in human cancer cell line |
| title_fullStr | Anti-metastatic mechanism of mountain cultivated wild ginseng in human cancer cell line |
| title_full_unstemmed | Anti-metastatic mechanism of mountain cultivated wild ginseng in human cancer cell line |
| title_short | Anti-metastatic mechanism of mountain cultivated wild ginseng in human cancer cell line |
| title_sort | anti metastatic mechanism of mountain cultivated wild ginseng in human cancer cell line |
| topic | Ginseng cultivated wild ginseng antimetastasis activities AXIN2 gene |
| url | http://dx.doi.org/10.3831/KPI.2010.13.1.037 |
| work_keys_str_mv | AT jangsb antimetastaticmechanismofmountaincultivatedwildginsenginhumancancercellline AT limcs antimetastaticmechanismofmountaincultivatedwildginsenginhumancancercellline AT jangjh antimetastaticmechanismofmountaincultivatedwildginsenginhumancancercellline AT kwonkr antimetastaticmechanismofmountaincultivatedwildginsenginhumancancercellline |