Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study
Abstract Introduction Overweight or obese children develop abnormal endothelial cell dysfunction and arterial intima–media thickening with increased vasomotor tone and inflammation. Curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D have shown beneficial effects on endothelial function....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-01-01
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| Series: | Nutrition & Diabetes |
| Online Access: | https://doi.org/10.1038/s41387-021-00180-1 |
| _version_ | 1798026541856194560 |
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| author | Pecoraro Luca Zoller Thomas Richard L. Atkinson Nisi Fulvio Antoniazzi Franco Cavarzere Paolo Piacentini Giorgio Pietrobelli Angelo |
| author_facet | Pecoraro Luca Zoller Thomas Richard L. Atkinson Nisi Fulvio Antoniazzi Franco Cavarzere Paolo Piacentini Giorgio Pietrobelli Angelo |
| author_sort | Pecoraro Luca |
| collection | DOAJ |
| description | Abstract Introduction Overweight or obese children develop abnormal endothelial cell dysfunction and arterial intima–media thickening with increased vasomotor tone and inflammation. Curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D have shown beneficial effects on endothelial function. We test, among overweight and obese pediatric subjects, the effects on the endothelium of a combination of curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D. Methods Forty-eight subjects (6–17 years) were randomized into two groups (placebo vs treatment) attended three visits at 0, 3, and 6 months (±15 days). Endothelial function was assessed by means of a post-occlusive release hyperemic (PORH) test for estimation of delta flow (DF) and hyperemic AUC index, and a heat provocation test (HPT) to measure DF HPT (DFHPT). Results Significant DF difference was noted at 6 months in both groups (p < 0.001). Overall time trend was significantly different between baseline, 3 months, and 6 months both in placebo (p < 0.05) and treatment (p < 0.001) groups and their comparison (p < 0.001). No differences were noted in hyperemic AUC index (3 and 6 months), whilst there were significant differences in time trends of rreatment (p < 0.001) and placebo (p < 0.05) groups and their comparison (p < 0.001). DFHPT difference between groups was significant at 3 and 6 months (p < 0.05). The overall time trend was significant exclusively in Treatment group between 3 and 6 months (p < 0.05). Correlation with anthropometrics was found for DF and body mass index (r = 0.677 6 months, p < 0.05), as well as for hyperemic AUC index and males (r = 0.348, p < 0.05), while DFHPT showed no correlation. Conclusion Curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D appear to be promising in enhancing endothelial function by improvement of both DF in the PORH test and DF in the HPT, lowering the risk of developing cardiovascular diseases in overweight and obese pediatric subjects. |
| first_indexed | 2024-04-11T18:36:58Z |
| format | Article |
| id | doaj.art-e59507408a484ae58bd7347466d6061b |
| institution | Directory Open Access Journal |
| issn | 2044-4052 |
| language | English |
| last_indexed | 2024-04-11T18:36:58Z |
| publishDate | 2022-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Nutrition & Diabetes |
| spelling | doaj.art-e59507408a484ae58bd7347466d6061b2022-12-22T04:09:13ZengNature Publishing GroupNutrition & Diabetes2044-40522022-01-011211810.1038/s41387-021-00180-1Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX studyPecoraro Luca0Zoller Thomas1Richard L. Atkinson2Nisi Fulvio3Antoniazzi Franco4Cavarzere Paolo5Piacentini Giorgio6Pietrobelli Angelo7Department of Medicine, University of VeronaPediatric Unit, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of VeronaDepartment of Medicine, Virginia Commonwealth UniversityHumanitas Clinical and Research Center—IRCCSPediatric Unit, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of VeronaPediatric Unit, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of VeronaPediatric Unit, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of VeronaPediatric Unit, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of VeronaAbstract Introduction Overweight or obese children develop abnormal endothelial cell dysfunction and arterial intima–media thickening with increased vasomotor tone and inflammation. Curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D have shown beneficial effects on endothelial function. We test, among overweight and obese pediatric subjects, the effects on the endothelium of a combination of curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D. Methods Forty-eight subjects (6–17 years) were randomized into two groups (placebo vs treatment) attended three visits at 0, 3, and 6 months (±15 days). Endothelial function was assessed by means of a post-occlusive release hyperemic (PORH) test for estimation of delta flow (DF) and hyperemic AUC index, and a heat provocation test (HPT) to measure DF HPT (DFHPT). Results Significant DF difference was noted at 6 months in both groups (p < 0.001). Overall time trend was significantly different between baseline, 3 months, and 6 months both in placebo (p < 0.05) and treatment (p < 0.001) groups and their comparison (p < 0.001). No differences were noted in hyperemic AUC index (3 and 6 months), whilst there were significant differences in time trends of rreatment (p < 0.001) and placebo (p < 0.05) groups and their comparison (p < 0.001). DFHPT difference between groups was significant at 3 and 6 months (p < 0.05). The overall time trend was significant exclusively in Treatment group between 3 and 6 months (p < 0.05). Correlation with anthropometrics was found for DF and body mass index (r = 0.677 6 months, p < 0.05), as well as for hyperemic AUC index and males (r = 0.348, p < 0.05), while DFHPT showed no correlation. Conclusion Curcumin, resveratrol, zinc, magnesium, selenium, and vitamin D appear to be promising in enhancing endothelial function by improvement of both DF in the PORH test and DF in the HPT, lowering the risk of developing cardiovascular diseases in overweight and obese pediatric subjects.https://doi.org/10.1038/s41387-021-00180-1 |
| spellingShingle | Pecoraro Luca Zoller Thomas Richard L. Atkinson Nisi Fulvio Antoniazzi Franco Cavarzere Paolo Piacentini Giorgio Pietrobelli Angelo Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study Nutrition & Diabetes |
| title | Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study |
| title_full | Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study |
| title_fullStr | Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study |
| title_full_unstemmed | Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study |
| title_short | Supportive treatment of vascular dysfunction in pediatric subjects with obesity: the OBELIX study |
| title_sort | supportive treatment of vascular dysfunction in pediatric subjects with obesity the obelix study |
| url | https://doi.org/10.1038/s41387-021-00180-1 |
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