Neuroprotective Potential of Seed Extracts: Review of In Vitro and In Vivo Studies
Introduction: Neurodegenerative diseases are characterized by neuronal dysfunction and death. Studies suggest that some seed extracts have a neuroprotective effect. Considering the increased incidence of these diseases and the need for new effective therapies with fewer side effects, this review aim...
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MDPI AG
2023-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/11/2502 |
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| author | Gabriella Mendes Duarte Francisco Emanoel Alves de Araújo João Matheus Caé da Rocha Francisca Idalina Neta Amália Cinthia Meneses do Rego Irami Araújo Filho Francisco Irochima Pinheiro Eduardo Pereira de Azevedo Ricardo Ney Cobucci Fausto Pierdoná Guzen |
| author_facet | Gabriella Mendes Duarte Francisco Emanoel Alves de Araújo João Matheus Caé da Rocha Francisca Idalina Neta Amália Cinthia Meneses do Rego Irami Araújo Filho Francisco Irochima Pinheiro Eduardo Pereira de Azevedo Ricardo Ney Cobucci Fausto Pierdoná Guzen |
| author_sort | Gabriella Mendes Duarte |
| collection | DOAJ |
| description | Introduction: Neurodegenerative diseases are characterized by neuronal dysfunction and death. Studies suggest that some seed extracts have a neuroprotective effect. Considering the increased incidence of these diseases and the need for new effective therapies with fewer side effects, this review aimed to assess the evidence of the efficacy and safety of seed extracts in experimental models of neurodegeneration. Material and Method: The search was carried out through studies published between 2000 and 2021 in Science Direct, PubMed, Scientific Electronic Library Online (SciELO), and Latin American Literature in Health Sciences (LILACS) databases, in which the effects of seed extracts in in vitro and in vivo experimental models of neurodegeneration were investigated. Based on the eligibility criteria, 47 studies were selected for this review. Results: In the in vitro models, the neuroprotection of the seed extracts was a result of their antioxidant, anti-inflammatory, and anti-apoptotic properties. In the in vivo models, neuroprotection resulted from the antioxidant and anti-inflammatory properties, a decrease in motor deficits, an improvement in learning and memory, as well as the increased release of neurotransmitters. The results show promise for the future of clinical research on new therapies for neurodegenerative diseases. However, the studies are still limited, which does not allow us to extrapolate the results to human beings with ND. Conclusions: Therefore, clinical trials are needed in order to prove the results of the in vitro and in vivo studies, as well as to assess the ideal, safe, and effective dose of these seed extracts in patients with neurodegenerative diseases. |
| first_indexed | 2024-03-11T03:01:09Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T03:01:09Z |
| publishDate | 2023-05-01 |
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| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e59964a7ce3c46dc8c5fd44c2a10a7842023-11-18T08:20:59ZengMDPI AGNutrients2072-66432023-05-011511250210.3390/nu15112502Neuroprotective Potential of Seed Extracts: Review of In Vitro and In Vivo StudiesGabriella Mendes Duarte0Francisco Emanoel Alves de Araújo1João Matheus Caé da Rocha2Francisca Idalina Neta3Amália Cinthia Meneses do Rego4Irami Araújo Filho5Francisco Irochima Pinheiro6Eduardo Pereira de Azevedo7Ricardo Ney Cobucci8Fausto Pierdoná Guzen9Postgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, BrazilGraduating in Pharmacy, Health School, Potiguar University (UnP), Mossoró 59056-000, BrazilGraduated in Nutrition, Health School, Potiguar University (UnP), Mossoró 59056-000, BrazilPostgraduate Program in Physiological Sciences, Department of Biomedical Sciences, Faculty of Health Sciences, State University of Rio Grande do Norte (UERN), Mossoró 59610-210, BrazilPostgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, BrazilPostgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, BrazilPostgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, BrazilPostgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, BrazilPostgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, BrazilPostgraduate Program in Biotechnology, Health School, Potiguar University (UnP), Natal 59056-000, BrazilIntroduction: Neurodegenerative diseases are characterized by neuronal dysfunction and death. Studies suggest that some seed extracts have a neuroprotective effect. Considering the increased incidence of these diseases and the need for new effective therapies with fewer side effects, this review aimed to assess the evidence of the efficacy and safety of seed extracts in experimental models of neurodegeneration. Material and Method: The search was carried out through studies published between 2000 and 2021 in Science Direct, PubMed, Scientific Electronic Library Online (SciELO), and Latin American Literature in Health Sciences (LILACS) databases, in which the effects of seed extracts in in vitro and in vivo experimental models of neurodegeneration were investigated. Based on the eligibility criteria, 47 studies were selected for this review. Results: In the in vitro models, the neuroprotection of the seed extracts was a result of their antioxidant, anti-inflammatory, and anti-apoptotic properties. In the in vivo models, neuroprotection resulted from the antioxidant and anti-inflammatory properties, a decrease in motor deficits, an improvement in learning and memory, as well as the increased release of neurotransmitters. The results show promise for the future of clinical research on new therapies for neurodegenerative diseases. However, the studies are still limited, which does not allow us to extrapolate the results to human beings with ND. Conclusions: Therefore, clinical trials are needed in order to prove the results of the in vitro and in vivo studies, as well as to assess the ideal, safe, and effective dose of these seed extracts in patients with neurodegenerative diseases.https://www.mdpi.com/2072-6643/15/11/2502seedsneurodegenerative diseasesneuroprotectionexperimental models |
| spellingShingle | Gabriella Mendes Duarte Francisco Emanoel Alves de Araújo João Matheus Caé da Rocha Francisca Idalina Neta Amália Cinthia Meneses do Rego Irami Araújo Filho Francisco Irochima Pinheiro Eduardo Pereira de Azevedo Ricardo Ney Cobucci Fausto Pierdoná Guzen Neuroprotective Potential of Seed Extracts: Review of In Vitro and In Vivo Studies Nutrients seeds neurodegenerative diseases neuroprotection experimental models |
| title | Neuroprotective Potential of Seed Extracts: Review of In Vitro and In Vivo Studies |
| title_full | Neuroprotective Potential of Seed Extracts: Review of In Vitro and In Vivo Studies |
| title_fullStr | Neuroprotective Potential of Seed Extracts: Review of In Vitro and In Vivo Studies |
| title_full_unstemmed | Neuroprotective Potential of Seed Extracts: Review of In Vitro and In Vivo Studies |
| title_short | Neuroprotective Potential of Seed Extracts: Review of In Vitro and In Vivo Studies |
| title_sort | neuroprotective potential of seed extracts review of in vitro and in vivo studies |
| topic | seeds neurodegenerative diseases neuroprotection experimental models |
| url | https://www.mdpi.com/2072-6643/15/11/2502 |
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