Synthesis, spectral studies and antibacterial activity of Cu(II), Co(II) and Ni(II) complexes of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol- -1-yl)methyl]hydrazone
A new series of Cu(II), Co(II) and Ni(II) complexes with the 1-(2- -hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol-1- -yl)methyl]hydrazone ligand, C21H22N4O (LH), were synthesized by the reaction of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, hydrazone with (3,5-dimethyl- 1H-p...
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Serbian Chemical Society
2009-01-01
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| Series: | Journal of the Serbian Chemical Society |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2009/0352-51390909927T.pdf |
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| author | Tharmaraj Paulmony Kodimunthiri Deivasigamani Sheela Clarence D. Priya Shanmuga Chappani S. |
| author_facet | Tharmaraj Paulmony Kodimunthiri Deivasigamani Sheela Clarence D. Priya Shanmuga Chappani S. |
| author_sort | Tharmaraj Paulmony |
| collection | DOAJ |
| description | A new series of Cu(II), Co(II) and Ni(II) complexes with the 1-(2- -hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol-1- -yl)methyl]hydrazone ligand, C21H22N4O (LH), were synthesized by the reaction of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, hydrazone with (3,5-dimethyl- 1H-pyrazol-1-yl)methanol and characterized. The nature of the bonding and geometry of the complexes were deduced from elemental analysis, IR, electronic and 1H-NMR spectroscopy, and magnetic susceptibility and conductivity measurements. The studies indicated square-planar, tetrahedral and octahedral geometry for the copper(II), cobalt(II) and nickel(II) complexes, respectively. The ESR spectra of the copper(II) complex in acetonitrile at 300 and 77 K were recorded and their salient features are reported. The electrochemical behavior of the copper (II) complex was studied by cyclic voltammetry. The antimicrobial activity of the ligand and its metal complexes were studied against the following strains of microorganism: Staphylococcus aureus, Salmonella enterica typhi, Escherichia coli and Bacillus subtilis by the well diffusion method. Metal complexes showed enhanced antimicrobial activity compared with that of the free ligand. |
| first_indexed | 2024-12-13T23:37:36Z |
| format | Article |
| id | doaj.art-e59a33ade0104033b77804caad8f8c03 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-13T23:37:36Z |
| publishDate | 2009-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-e59a33ade0104033b77804caad8f8c032022-12-21T23:27:16ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212009-01-01748-992793810.2298/JSC0909927T0352-51390909927TSynthesis, spectral studies and antibacterial activity of Cu(II), Co(II) and Ni(II) complexes of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol- -1-yl)methyl]hydrazoneTharmaraj Paulmony0Kodimunthiri Deivasigamani1Sheela Clarence D.2Priya Shanmuga Chappani S.3Department of Chemistry, Thiagarajar College, Madurai, IndiaDepartment of Chemistry, Thiagarajar College, Madurai, IndiaDepartment of Chemistry, the American College, Madurai, IndiaDepartment of Chemistry, Thiagarajar College, Madurai, IndiaA new series of Cu(II), Co(II) and Ni(II) complexes with the 1-(2- -hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol-1- -yl)methyl]hydrazone ligand, C21H22N4O (LH), were synthesized by the reaction of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, hydrazone with (3,5-dimethyl- 1H-pyrazol-1-yl)methanol and characterized. The nature of the bonding and geometry of the complexes were deduced from elemental analysis, IR, electronic and 1H-NMR spectroscopy, and magnetic susceptibility and conductivity measurements. The studies indicated square-planar, tetrahedral and octahedral geometry for the copper(II), cobalt(II) and nickel(II) complexes, respectively. The ESR spectra of the copper(II) complex in acetonitrile at 300 and 77 K were recorded and their salient features are reported. The electrochemical behavior of the copper (II) complex was studied by cyclic voltammetry. The antimicrobial activity of the ligand and its metal complexes were studied against the following strains of microorganism: Staphylococcus aureus, Salmonella enterica typhi, Escherichia coli and Bacillus subtilis by the well diffusion method. Metal complexes showed enhanced antimicrobial activity compared with that of the free ligand.http://www.doiserbia.nb.rs/img/doi/0352-5139/2009/0352-51390909927T.pdf3,5-dimethyl-1-(hydroxymethyl)pyrazole2'-hydroxychalconemetal complexespyrazolecu(ii), co(ii) and ni(ii) complexesantimicrobial activity |
| spellingShingle | Tharmaraj Paulmony Kodimunthiri Deivasigamani Sheela Clarence D. Priya Shanmuga Chappani S. Synthesis, spectral studies and antibacterial activity of Cu(II), Co(II) and Ni(II) complexes of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol- -1-yl)methyl]hydrazone Journal of the Serbian Chemical Society 3,5-dimethyl-1-(hydroxymethyl)pyrazole 2'-hydroxychalcone metal complexes pyrazole cu(ii), co(ii) and ni(ii) complexes antimicrobial activity |
| title | Synthesis, spectral studies and antibacterial activity of Cu(II), Co(II) and Ni(II) complexes of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol- -1-yl)methyl]hydrazone |
| title_full | Synthesis, spectral studies and antibacterial activity of Cu(II), Co(II) and Ni(II) complexes of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol- -1-yl)methyl]hydrazone |
| title_fullStr | Synthesis, spectral studies and antibacterial activity of Cu(II), Co(II) and Ni(II) complexes of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol- -1-yl)methyl]hydrazone |
| title_full_unstemmed | Synthesis, spectral studies and antibacterial activity of Cu(II), Co(II) and Ni(II) complexes of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol- -1-yl)methyl]hydrazone |
| title_short | Synthesis, spectral studies and antibacterial activity of Cu(II), Co(II) and Ni(II) complexes of 1-(2-hydroxyphenyl)-3-phenyl-2-propen-1-one, N2-[(3,5-dimethyl-1H-pyrazol- -1-yl)methyl]hydrazone |
| title_sort | synthesis spectral studies and antibacterial activity of cu ii co ii and ni ii complexes of 1 2 hydroxyphenyl 3 phenyl 2 propen 1 one n2 3 5 dimethyl 1h pyrazol 1 yl methyl hydrazone |
| topic | 3,5-dimethyl-1-(hydroxymethyl)pyrazole 2'-hydroxychalcone metal complexes pyrazole cu(ii), co(ii) and ni(ii) complexes antimicrobial activity |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2009/0352-51390909927T.pdf |
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