C-Reactive Protein in Bipolar Disorder in an Indian Clinical Setting
Introduction: Serious psychiatric illnesses like bipolar disorder lack specific biomarkers of diagnosis or prognosis. However, association between Bipolar Disorder (BD) and various inflammatory markers has been consistently demonstrated by earlier studies pointing to underlying inflammation/dysimmun...
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JCDR Research and Publications Private Limited
2018-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/12014/37177_CE[Ra1]_F(SL)_PF1(SH_SS)_PFA(MJ_AP)_PN(AP).pdf |
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| author | Aparna Sundaresh Ravi Philip Rajkumar Rajagopal Krishnamoorthy Marion Leboyer Vir Singh Negi Ryad Tamouza |
| author_facet | Aparna Sundaresh Ravi Philip Rajkumar Rajagopal Krishnamoorthy Marion Leboyer Vir Singh Negi Ryad Tamouza |
| author_sort | Aparna Sundaresh |
| collection | DOAJ |
| description | Introduction: Serious psychiatric illnesses like bipolar disorder lack specific biomarkers of diagnosis or prognosis. However, association between Bipolar Disorder (BD) and various inflammatory markers has been consistently demonstrated by earlier studies pointing to underlying inflammation/dysimmunity. Often implicated in particular is the acute phase C-Reactive Protein (CRP) of hepatic origin, a generic marker of inflammation which is robust and very easy to test even in field settings without the need for a laboratory. Aim: To study the status of CRP, a generic marker of inflammation, in a well-characterised south Indian Tamil BD cohort, and investigate whether it can be a specifier of disease state. Materials and Methods: CRP was qualitatively estimated by latex agglutination method in the serum of 145 BD patients and 151 healthy controls. Statistical analyses were performed to test the association of CRP with the disease state. Results: It was found that, after controlling for age, gender, BMI and smoking status, CRP positivity (>0.6 mg/dL) was: (i) significantly higher among BD patients compared to healthy controls; (ii) significantly higher among patients having an acute mood episode (both mania (n=85), and depression (n=9) combined) compared to patients with residual symptoms or in remission, as well as compared to healthy subjects; (iii) not significantly different between patients in acute mania versus acute depression, but significantly higher in both acute mania and in acute depression compared to patients with residual symptoms or in remission. Conclusion: CRP, a robust generic inflammatory marker is significantly higher among BD patients as compared to normal controls, pointing to underlying inflammation operating in the disease. Also, it can differentiate between patients in acute phase and those in remission or having residual symptoms. If validated in longitudinal follow-up studies, these results could be helpful in Point Of Care (POC), as well as field settings especially in low income countries to identify patients whose symptoms are progressing towards relapse, at low costs, and without the need for a sophisticated laboratory. |
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| language | English |
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| publishDate | 2018-09-01 |
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| spelling | doaj.art-e59a3425177e419aa54babe43405584d2022-12-21T21:11:42ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-09-01129VM01VM0310.7860/JCDR/2018/37177.12014C-Reactive Protein in Bipolar Disorder in an Indian Clinical SettingAparna Sundaresh0Ravi Philip Rajkumar1Rajagopal Krishnamoorthy2Marion Leboyer3Vir Singh Negi4Ryad Tamouza5Scholar and Senior Research Fellow, Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India; INSERM, U955, Psychiatrie Translationnelle, Henri Mondor Hospital, Créteil, F94000, France; INSERM, UMRS 1160, Saint Louis Hospital, Paris, France.Additional Professor and Head, Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.INSERM, UMRS 1160, Saint Louis Hospital, Paris, France; Fondation FondaMental, Créteil F94000, France.Fondation FondaMental, Créteil F94000, France; AP-HP, DHU PePSY, Pôle de Psychiatrie, Hôpitaux Universitaires Henri Mondor, Créteil, F94000, France; Université Paris-Est-Créteil, Faculté de Médecine, Créteil, F94000, France.Professor and Head, Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.Fondation FondaMental, Créteil F94000, France; AP-HP, DHU PePSY, Pôle de Psychiatrie, Hôpitaux Universitaires Henri Mondor, Créteil, F94000, France; Université Paris-Est-Créteil, Faculté de Médecine, Créteil, F94000, France.Introduction: Serious psychiatric illnesses like bipolar disorder lack specific biomarkers of diagnosis or prognosis. However, association between Bipolar Disorder (BD) and various inflammatory markers has been consistently demonstrated by earlier studies pointing to underlying inflammation/dysimmunity. Often implicated in particular is the acute phase C-Reactive Protein (CRP) of hepatic origin, a generic marker of inflammation which is robust and very easy to test even in field settings without the need for a laboratory. Aim: To study the status of CRP, a generic marker of inflammation, in a well-characterised south Indian Tamil BD cohort, and investigate whether it can be a specifier of disease state. Materials and Methods: CRP was qualitatively estimated by latex agglutination method in the serum of 145 BD patients and 151 healthy controls. Statistical analyses were performed to test the association of CRP with the disease state. Results: It was found that, after controlling for age, gender, BMI and smoking status, CRP positivity (>0.6 mg/dL) was: (i) significantly higher among BD patients compared to healthy controls; (ii) significantly higher among patients having an acute mood episode (both mania (n=85), and depression (n=9) combined) compared to patients with residual symptoms or in remission, as well as compared to healthy subjects; (iii) not significantly different between patients in acute mania versus acute depression, but significantly higher in both acute mania and in acute depression compared to patients with residual symptoms or in remission. Conclusion: CRP, a robust generic inflammatory marker is significantly higher among BD patients as compared to normal controls, pointing to underlying inflammation operating in the disease. Also, it can differentiate between patients in acute phase and those in remission or having residual symptoms. If validated in longitudinal follow-up studies, these results could be helpful in Point Of Care (POC), as well as field settings especially in low income countries to identify patients whose symptoms are progressing towards relapse, at low costs, and without the need for a sophisticated laboratory.https://jcdr.net/articles/PDF/12014/37177_CE[Ra1]_F(SL)_PF1(SH_SS)_PFA(MJ_AP)_PN(AP).pdfinflammationlatex agglutinationpsychoneuroimmunology |
| spellingShingle | Aparna Sundaresh Ravi Philip Rajkumar Rajagopal Krishnamoorthy Marion Leboyer Vir Singh Negi Ryad Tamouza C-Reactive Protein in Bipolar Disorder in an Indian Clinical Setting Journal of Clinical and Diagnostic Research inflammation latex agglutination psychoneuroimmunology |
| title | C-Reactive Protein in Bipolar Disorder in an Indian Clinical Setting |
| title_full | C-Reactive Protein in Bipolar Disorder in an Indian Clinical Setting |
| title_fullStr | C-Reactive Protein in Bipolar Disorder in an Indian Clinical Setting |
| title_full_unstemmed | C-Reactive Protein in Bipolar Disorder in an Indian Clinical Setting |
| title_short | C-Reactive Protein in Bipolar Disorder in an Indian Clinical Setting |
| title_sort | c reactive protein in bipolar disorder in an indian clinical setting |
| topic | inflammation latex agglutination psychoneuroimmunology |
| url | https://jcdr.net/articles/PDF/12014/37177_CE[Ra1]_F(SL)_PF1(SH_SS)_PFA(MJ_AP)_PN(AP).pdf |
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