Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis

Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis

Abstract Background Idiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by aberrant fibroblast activation and progressive fibrotic remodelling of the lungs. Though the exact pathophysiological mechanisms of IPF remain unknown, TGF-β1 is thought to act as a main driver of...

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Bibliographic Details
Main Authors: Eva Schruf, Victoria Schroeder, Christian A. Kuttruff, Sabine Weigle, Martin Krell, Maryke Benz, Tom Bretschneider, Alexander Holweg, Michael Schuler, Manfred Frick, Paul Nicklin, James P. Garnett, Mirko C. Sobotta
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Respiratory Research
Subjects:
Idiopathic pulmonary fibrosis
Fibroblast-to-myofibroblast transformation
Metabolic shift
Aerobic glycolysis
Lactate dehydrogenase
TGF-β1
Online Access:http://link.springer.com/article/10.1186/s12931-019-1058-2

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