The ZJU index is associated with the risk of obstructive sleep apnea syndrome in Chinese middle-aged and older people: a cross-sectional study
Abstract Background The ZJU index, a novel calculation that combines body mass index, triglycerides, fasting blood glucose and the ratio of alanine aminotransferase to aspartate aminotransferase, is a closely related measure of obesity and insulin resistance. Studies of the ZJU index in relation to...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-023-01974-1 |
| _version_ | 1797414209920696320 |
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| author | Liping Wang Guqiao Nie Fengqin Yan Nianli Zhou Meng Zhang Wen Peng |
| author_facet | Liping Wang Guqiao Nie Fengqin Yan Nianli Zhou Meng Zhang Wen Peng |
| author_sort | Liping Wang |
| collection | DOAJ |
| description | Abstract Background The ZJU index, a novel calculation that combines body mass index, triglycerides, fasting blood glucose and the ratio of alanine aminotransferase to aspartate aminotransferase, is a closely related measure of obesity and insulin resistance. Studies of the ZJU index in relation to obstructive sleep apnea syndrome (OSAS) have not been reported. This study assessed the correlation between the ZJU values and OSAS risk. Methods A total of 2,130 participants who underwent polysomnographic monitoring were included in the study. The participants’ basic information and laboratory biochemical indicators were collected, and the ZJU index was computed. The ZJU index was divided into quartiles. The correlation between the different ZJU index levels and OSAS risk was assessed using logistic regression. Drew a receiver operating characteristic (ROC) relationship curve, with prediction efficacy judged by the area under the curve (AUC), and found the optimum cut-off point for ZJU index to predict OSAS. Relative risks were presented as odds ratios (OR). The range of OR values is expressed in the form of 95% confidence intervals (95% CI). Results The number of patients diagnosed with OSAS increased progressively with increasing ZJU index (T1: 9.4%; T2: 20.6%; T3: 28.3%; T4: 41.7%; P < 0.001). The additional confounders were adjusted by the logistic regression models, the study revealed an independent correlation between ZJU index and OSAS. (P < 0.001). The OSAS risk was notably higher at the highest ZJU index levels. (OR = 2.046 [95% CI: 1.057 to 3.964]). The ROC curve for the ZJU index showed an AUC of 0.64 (P < 0.001) for males and 0.75 (P < 0.001) for females, with a specificity of 64% and 55% and a sensitivity of 60% and 92% for males and females, respectively, with the optimum cut-off values of 36.568 and 34.722, respectively. Conclusion A high ZJU index was significantly associated with an increasing risk of OSAS. The ZJU is expected to be a meaningful index for detecting OSAS in the general population. |
| first_indexed | 2024-03-09T05:28:46Z |
| format | Article |
| id | doaj.art-e59ba1fe6b444fc5b8e63a5c90fdbac0 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-03-09T05:28:46Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-e59ba1fe6b444fc5b8e63a5c90fdbac02023-12-03T12:34:33ZengBMCLipids in Health and Disease1476-511X2023-11-012211810.1186/s12944-023-01974-1The ZJU index is associated with the risk of obstructive sleep apnea syndrome in Chinese middle-aged and older people: a cross-sectional studyLiping Wang0Guqiao Nie1Fengqin Yan2Nianli Zhou3Meng Zhang4Wen Peng5General Practice Department, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyGeneral Practice Department, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyGeneral Practice Department, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyGeneral Practice Department, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyGeneral Practice Department, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyGeneral Practice Department, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background The ZJU index, a novel calculation that combines body mass index, triglycerides, fasting blood glucose and the ratio of alanine aminotransferase to aspartate aminotransferase, is a closely related measure of obesity and insulin resistance. Studies of the ZJU index in relation to obstructive sleep apnea syndrome (OSAS) have not been reported. This study assessed the correlation between the ZJU values and OSAS risk. Methods A total of 2,130 participants who underwent polysomnographic monitoring were included in the study. The participants’ basic information and laboratory biochemical indicators were collected, and the ZJU index was computed. The ZJU index was divided into quartiles. The correlation between the different ZJU index levels and OSAS risk was assessed using logistic regression. Drew a receiver operating characteristic (ROC) relationship curve, with prediction efficacy judged by the area under the curve (AUC), and found the optimum cut-off point for ZJU index to predict OSAS. Relative risks were presented as odds ratios (OR). The range of OR values is expressed in the form of 95% confidence intervals (95% CI). Results The number of patients diagnosed with OSAS increased progressively with increasing ZJU index (T1: 9.4%; T2: 20.6%; T3: 28.3%; T4: 41.7%; P < 0.001). The additional confounders were adjusted by the logistic regression models, the study revealed an independent correlation between ZJU index and OSAS. (P < 0.001). The OSAS risk was notably higher at the highest ZJU index levels. (OR = 2.046 [95% CI: 1.057 to 3.964]). The ROC curve for the ZJU index showed an AUC of 0.64 (P < 0.001) for males and 0.75 (P < 0.001) for females, with a specificity of 64% and 55% and a sensitivity of 60% and 92% for males and females, respectively, with the optimum cut-off values of 36.568 and 34.722, respectively. Conclusion A high ZJU index was significantly associated with an increasing risk of OSAS. The ZJU is expected to be a meaningful index for detecting OSAS in the general population.https://doi.org/10.1186/s12944-023-01974-1ZJU indexObstructive sleep apnea syndromeMetabolism |
| spellingShingle | Liping Wang Guqiao Nie Fengqin Yan Nianli Zhou Meng Zhang Wen Peng The ZJU index is associated with the risk of obstructive sleep apnea syndrome in Chinese middle-aged and older people: a cross-sectional study Lipids in Health and Disease ZJU index Obstructive sleep apnea syndrome Metabolism |
| title | The ZJU index is associated with the risk of obstructive sleep apnea syndrome in Chinese middle-aged and older people: a cross-sectional study |
| title_full | The ZJU index is associated with the risk of obstructive sleep apnea syndrome in Chinese middle-aged and older people: a cross-sectional study |
| title_fullStr | The ZJU index is associated with the risk of obstructive sleep apnea syndrome in Chinese middle-aged and older people: a cross-sectional study |
| title_full_unstemmed | The ZJU index is associated with the risk of obstructive sleep apnea syndrome in Chinese middle-aged and older people: a cross-sectional study |
| title_short | The ZJU index is associated with the risk of obstructive sleep apnea syndrome in Chinese middle-aged and older people: a cross-sectional study |
| title_sort | zju index is associated with the risk of obstructive sleep apnea syndrome in chinese middle aged and older people a cross sectional study |
| topic | ZJU index Obstructive sleep apnea syndrome Metabolism |
| url | https://doi.org/10.1186/s12944-023-01974-1 |
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