Understanding the Roles of the Hedgehog Signaling Pathway during T-Cell Lymphopoiesis and in T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Understanding the Roles of the Hedgehog Signaling Pathway during T-Cell Lymphopoiesis and in T-Cell Acute Lymphoblastic Leukemia (T-ALL)

The Hedgehog (HH) signaling network is one of the main regulators of invertebrate and vertebrate embryonic development. Along with other networks, such as NOTCH and WNT, HH signaling specifies both the early patterning and the polarity events as well as the subsequent organ formation via the tempora...

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Bibliographic Details
Main Authors: Alberto M. Martelli, Francesca Paganelli, Serena Truocchio, Carla Palumbo, Francesca Chiarini, James A. McCubrey
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
Hedgehog signaling
thymocyte differentiation
T-ALL
targeted therapy
crosstalk
signaling pathways
Online Access:https://www.mdpi.com/1422-0067/24/3/2962

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