Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway

Moderate mechanical stress suppresses chondrocyte ferroptosis in osteoarthritis by regulating NF-κB p65/GPX4 signaling pathway

Abstract Ferroptosis is a recently identified form of programmed cell death that plays an important role in the pathophysiological process of osteoarthritis (OA). Herein, we investigated the protective effect of moderate mechanical stress on chondrocyte ferroptosis and further revealed the internal...

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Bibliographic Details
Main Authors: Juanjuan Han, Li-nan Zhan, Yue Huang, Shijia Guo, Xiaoding Zhou, Leonid Kapilevich, Zhuo Wang, Ke Ning, Mingli Sun, Xin-an Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Mechanical stress
Osteoarthritis
Ferroptosis
Cartilage
Online Access:https://doi.org/10.1038/s41598-024-55629-x

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