Chrysin a promising anticancer agent: recent perspectives
ABSTRACTHoney, propolis, and passionflower contain a flavone known as chrysin. Researchers are studying chrysin to prove its potential to stop cancer cells growth. Chrysin cancer therapeutic potential is of great interest and numerous studies have been done to illustrate this potential. It is associ...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-09-01
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| Series: | International Journal of Food Properties |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/10942912.2023.2246678 |
| _version_ | 1797202497923710976 |
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| author | Muhammad Shahbaz Hammad Naeem Muhammad Imran Hammad Ul Hassan Suliman A. Alsagaby Waleed Al Abdulmonem Ahmed Bilal Waqar Ahmed H. Ghorab Mohamed A. Abdelgawad Mohammed M. Ghoneim Muzzamal Hussain Entessar Al Jbawi Amna Ihsan |
| author_facet | Muhammad Shahbaz Hammad Naeem Muhammad Imran Hammad Ul Hassan Suliman A. Alsagaby Waleed Al Abdulmonem Ahmed Bilal Waqar Ahmed H. Ghorab Mohamed A. Abdelgawad Mohammed M. Ghoneim Muzzamal Hussain Entessar Al Jbawi Amna Ihsan |
| author_sort | Muhammad Shahbaz |
| collection | DOAJ |
| description | ABSTRACTHoney, propolis, and passionflower contain a flavone known as chrysin. Researchers are studying chrysin to prove its potential to stop cancer cells growth. Chrysin cancer therapeutic potential is of great interest and numerous studies have been done to illustrate this potential. It is associated protein pathways effectively suppress tumor growth within the body. It is shown to have the ability to kill breast, prostate, lung, liver, and stomach cancerous cells. It can block Phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) and Mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling in different animals against various cancers. Chrysin has the potential to kill breast cancer cells in a laboratory setting by inhibiting their cell division. Chrysin strongly suppresses Matrix metalloproteinase-9 (MMP-9), Urokinase plasminogen activator (uPA) and Vascular endothelial growth factor (VEGF), i.e. factors that can cause cancer. Chrysin has the ability to suppress the androgen receptor (AR), a protein necessary for prostate cancer development and metastasis. It starts the caspase cascade and blocks protein synthesis to kill lung cancer cells. Unnecessary apoptosis can be prevented by stopping certain protein pathways. Chrysin significantly decreased lung cancer metastasis in various animal-modeled studies. Chrysin induces apoptosis and stops colon cancer cells in the G2/M cell cycle phase. Chrysin suppresses colon cancer-promoting cyclin B1 and cyclin-dependent kinase 2. Chrysin suppressed cyclin B1 and CDK2 production in order to stop cancerous growth. Chrysin prevents tumor growth and cancer spread by blocking blood vessel expansion. Chrysin’s solubility, accessibility and bioavailability may limit its medical use. Chrysin targets numerous cancer-related communication pathways present in cells. Chrysin may reduce the chances of the onset of cancer, it can also serve as an alternative treatment as a whole to prevent and treat various cancers, but more clinical trials and research studies are needed to fully unlock its potential. |
| first_indexed | 2024-03-11T18:20:35Z |
| format | Article |
| id | doaj.art-e59ce7df96164b41890ae790769f8793 |
| institution | Directory Open Access Journal |
| issn | 1094-2912 1532-2386 |
| language | English |
| last_indexed | 2024-04-24T08:04:23Z |
| publishDate | 2023-09-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Food Properties |
| spelling | doaj.art-e59ce7df96164b41890ae790769f87932024-04-17T13:20:13ZengTaylor & Francis GroupInternational Journal of Food Properties1094-29121532-23862023-09-012612294233710.1080/10942912.2023.2246678Chrysin a promising anticancer agent: recent perspectivesMuhammad Shahbaz0Hammad Naeem1Muhammad Imran2Hammad Ul Hassan3Suliman A. Alsagaby4Waleed Al Abdulmonem5Ahmed Bilal Waqar6Ahmed H. Ghorab7Mohamed A. Abdelgawad8Mohammed M. Ghoneim9Muzzamal Hussain10Entessar Al Jbawi11Amna Ihsan12Department of Food Science and Technology, Muhammad Nawaz Shareef University of Agriculture Multan, Multan, PakistanDepartment of Food Science and Technology, Muhammad Nawaz Shareef University of Agriculture Multan, Multan, PakistanDepartment of Food Science and Technology, University of Narowal-Pakistan, Narowal, PakistanDepartment of Food Science and Technology, Muhammad Nawaz Shareef University of Agriculture Multan, Multan, PakistanDepartment of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, AL-Majmaah, Saudi ArabiaDepartment of Pathology, College of Medicine, Qassim University, Buraidah, Kingdom of Saudi ArabiaFaculty of Allied Health Sciences, The University of Chenab, Gujrat, PakistanDepartment of Chemistry, College of Science, Jouf University, Sakaka, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi ArabiaDepartment of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi ArabiaDepartment of Food Sciences, Government College University Faisalabad, Faisalabad, PakistanAgricultural Extension Directorate, MAAR, Damascus, SyriaDepartment of Biochemistry, King Edward Medical University, Lahore, PakistanABSTRACTHoney, propolis, and passionflower contain a flavone known as chrysin. Researchers are studying chrysin to prove its potential to stop cancer cells growth. Chrysin cancer therapeutic potential is of great interest and numerous studies have been done to illustrate this potential. It is associated protein pathways effectively suppress tumor growth within the body. It is shown to have the ability to kill breast, prostate, lung, liver, and stomach cancerous cells. It can block Phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) and Mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling in different animals against various cancers. Chrysin has the potential to kill breast cancer cells in a laboratory setting by inhibiting their cell division. Chrysin strongly suppresses Matrix metalloproteinase-9 (MMP-9), Urokinase plasminogen activator (uPA) and Vascular endothelial growth factor (VEGF), i.e. factors that can cause cancer. Chrysin has the ability to suppress the androgen receptor (AR), a protein necessary for prostate cancer development and metastasis. It starts the caspase cascade and blocks protein synthesis to kill lung cancer cells. Unnecessary apoptosis can be prevented by stopping certain protein pathways. Chrysin significantly decreased lung cancer metastasis in various animal-modeled studies. Chrysin induces apoptosis and stops colon cancer cells in the G2/M cell cycle phase. Chrysin suppresses colon cancer-promoting cyclin B1 and cyclin-dependent kinase 2. Chrysin suppressed cyclin B1 and CDK2 production in order to stop cancerous growth. Chrysin prevents tumor growth and cancer spread by blocking blood vessel expansion. Chrysin’s solubility, accessibility and bioavailability may limit its medical use. Chrysin targets numerous cancer-related communication pathways present in cells. Chrysin may reduce the chances of the onset of cancer, it can also serve as an alternative treatment as a whole to prevent and treat various cancers, but more clinical trials and research studies are needed to fully unlock its potential.https://www.tandfonline.com/doi/10.1080/10942912.2023.2246678Chrysinhoneypropolisantioxidantanticancermedicinal properties |
| spellingShingle | Muhammad Shahbaz Hammad Naeem Muhammad Imran Hammad Ul Hassan Suliman A. Alsagaby Waleed Al Abdulmonem Ahmed Bilal Waqar Ahmed H. Ghorab Mohamed A. Abdelgawad Mohammed M. Ghoneim Muzzamal Hussain Entessar Al Jbawi Amna Ihsan Chrysin a promising anticancer agent: recent perspectives International Journal of Food Properties Chrysin honey propolis antioxidant anticancer medicinal properties |
| title | Chrysin a promising anticancer agent: recent perspectives |
| title_full | Chrysin a promising anticancer agent: recent perspectives |
| title_fullStr | Chrysin a promising anticancer agent: recent perspectives |
| title_full_unstemmed | Chrysin a promising anticancer agent: recent perspectives |
| title_short | Chrysin a promising anticancer agent: recent perspectives |
| title_sort | chrysin a promising anticancer agent recent perspectives |
| topic | Chrysin honey propolis antioxidant anticancer medicinal properties |
| url | https://www.tandfonline.com/doi/10.1080/10942912.2023.2246678 |
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