Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses
Aim: Paracetamol is widely used by important societal groups such as pregnant women and the elderly. Paracetamol, taken in high doses especially during pregnancy, causes liver failure. The aim of our study is to investigate the effects of paracetamol, which is widely used during pregnancy, on the fe...
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| Format: | Article |
| Language: | English |
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Alanya Alaaddin Keykubat University
2020-07-01
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| Series: | Acta Medica Alanya |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/pub/medalanya/issue/56070/688286?publisher=alku |
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| author | Seher Yi̇lmaz Yeşim Göçmen Adem Tokpınar İlyas Uçar Şükrü Ateş Seda Avni̇oğlu Mehtap Ni̇sari̇ |
| author_facet | Seher Yi̇lmaz Yeşim Göçmen Adem Tokpınar İlyas Uçar Şükrü Ateş Seda Avni̇oğlu Mehtap Ni̇sari̇ |
| author_sort | Seher Yi̇lmaz |
| collection | DOAJ |
| description | Aim: Paracetamol is widely used by important societal groups such as pregnant women and the elderly. Paracetamol, taken in high doses especially during pregnancy, causes liver failure. The aim of our study is to investigate the effects of paracetamol, which is widely used during pregnancy, on the fetal liver. Methods: In our study, five groups of randomly selected rats from 10 Wistar Albino rats (n=2) were formed as control group, 50 mg / kg paracetamol group, 125 mg / kg paracetamol group, 250 mg / kg paracetamol group and 500 mg / kg paracetamol group. Paracetamol by gavage was given to pregnant rats in specified doses. Fetuses were taken by cesarean on the 20th day of pregnancy (10 fetuses were taken from each group). The fetus livers were then taken for biochemical analysis. Biochemically, vascular endothelial growth factor A (VEGF-A), FETU-A (FETUIN-A) (α2-heremans-schmid glikoprotein) and Sclerostin (SOST) values were examined.Results: In this study, changes in liver hepatocyte cells are seen as the dose of paracetamol increases. Regular increase is observed in VEGF-A and FETU-A. SOST increased at a dose of 250 mg / kg and decreased in the group of 500 mg / kg paracetamol. (p<0.05).Conclusions: As a result, it is seen that the use of high doses of paracetamol in pregnancy causes changes in the liver and many biochemical values on the fetus. We think that an overdosing of paracetamol, which is sold without prescription and used as an innocent analgesic during pregnancy, should be examined and this study will be a reference for other studies to be conducted. |
| first_indexed | 2024-04-10T11:16:13Z |
| format | Article |
| id | doaj.art-e59d06f6c77d4f3d9f430ee83586bc2f |
| institution | Directory Open Access Journal |
| issn | 2587-0319 |
| language | English |
| last_indexed | 2024-04-10T11:16:13Z |
| publishDate | 2020-07-01 |
| publisher | Alanya Alaaddin Keykubat University |
| record_format | Article |
| series | Acta Medica Alanya |
| spelling | doaj.art-e59d06f6c77d4f3d9f430ee83586bc2f2023-02-15T16:18:50ZengAlanya Alaaddin Keykubat UniversityActa Medica Alanya2587-03192020-07-014215015510.30565/medalanya.688286727Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat FetusesSeher Yi̇lmazYeşim Göçmen0Adem Tokpınar1İlyas Uçar2Şükrü Ateş3Seda Avni̇oğlu4Mehtap Ni̇sari̇5BOZOK ÜNİVERSİTESİYOZGAT BOZOK ÜNİVERSİTESİ, TIP FAKÜLTESİAHİ EVRAN ÜNİVERSİTESİBOZOK ÜNİVERSİTESİALANYA ALAADDİN KEYKUBAT ÜNİVERSİTESİERCİYES ÜNİVERSİTESİ, TIP FAKÜLTESİAim: Paracetamol is widely used by important societal groups such as pregnant women and the elderly. Paracetamol, taken in high doses especially during pregnancy, causes liver failure. The aim of our study is to investigate the effects of paracetamol, which is widely used during pregnancy, on the fetal liver. Methods: In our study, five groups of randomly selected rats from 10 Wistar Albino rats (n=2) were formed as control group, 50 mg / kg paracetamol group, 125 mg / kg paracetamol group, 250 mg / kg paracetamol group and 500 mg / kg paracetamol group. Paracetamol by gavage was given to pregnant rats in specified doses. Fetuses were taken by cesarean on the 20th day of pregnancy (10 fetuses were taken from each group). The fetus livers were then taken for biochemical analysis. Biochemically, vascular endothelial growth factor A (VEGF-A), FETU-A (FETUIN-A) (α2-heremans-schmid glikoprotein) and Sclerostin (SOST) values were examined.Results: In this study, changes in liver hepatocyte cells are seen as the dose of paracetamol increases. Regular increase is observed in VEGF-A and FETU-A. SOST increased at a dose of 250 mg / kg and decreased in the group of 500 mg / kg paracetamol. (p<0.05).Conclusions: As a result, it is seen that the use of high doses of paracetamol in pregnancy causes changes in the liver and many biochemical values on the fetus. We think that an overdosing of paracetamol, which is sold without prescription and used as an innocent analgesic during pregnancy, should be examined and this study will be a reference for other studies to be conducted.https://dergipark.org.tr/en/pub/medalanya/issue/56070/688286?publisher=alkuvegfparacetamollivervegf-afetusvegfparasetamolkaraciğervegf-afetüs |
| spellingShingle | Seher Yi̇lmaz Yeşim Göçmen Adem Tokpınar İlyas Uçar Şükrü Ateş Seda Avni̇oğlu Mehtap Ni̇sari̇ Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses Acta Medica Alanya vegf paracetamol liver vegf-a fetus vegf parasetamol karaciğer vegf-a fetüs |
| title | Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses |
| title_full | Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses |
| title_fullStr | Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses |
| title_full_unstemmed | Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses |
| title_short | Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses |
| title_sort | effects of paracetamol on vascular endothelial growth factor sclerostin and fetuin a in the liver of rat fetuses |
| topic | vegf paracetamol liver vegf-a fetus vegf parasetamol karaciğer vegf-a fetüs |
| url | https://dergipark.org.tr/en/pub/medalanya/issue/56070/688286?publisher=alku |
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