Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D

Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D

Experience and activity refine cortical circuits through synapse elimination, but little is known about the activity patterns and downstream molecular mechanisms that mediate this process. We used optogenetics to drive individual mouse CA1 hippocampal neurons to fire in theta frequency bursts to und...

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Bibliographic Details
Main Authors: Chia-Wei Chang, Julia R Wilkerson, Carly F Hale, Jay R Gibson, Kimberly M Huber
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
MEF2
synapse silencing
activity-dependent synapse plasticity
Online Access:https://elifesciences.org/articles/26278

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