Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis
Metabolic-associated fatty liver disease (MAFLD) and its potential impact on the severity of COVID-19 have gained significant attention during the pandemic. This review aimed to explore the genetic determinants associated with MAFLD, previously recognized as non-alcoholic fatty liver disease (NAFLD)...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/8/1724 |
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| author | Mykhailo Buchynskyi Valentyn Oksenych Iryna Kamyshna Sandor G. Vari Aleksandr Kamyshnyi |
| author_facet | Mykhailo Buchynskyi Valentyn Oksenych Iryna Kamyshna Sandor G. Vari Aleksandr Kamyshnyi |
| author_sort | Mykhailo Buchynskyi |
| collection | DOAJ |
| description | Metabolic-associated fatty liver disease (MAFLD) and its potential impact on the severity of COVID-19 have gained significant attention during the pandemic. This review aimed to explore the genetic determinants associated with MAFLD, previously recognized as non-alcoholic fatty liver disease (NAFLD), and their potential influence on COVID-19 outcomes. Various genetic polymorphisms, including PNPLA3 (rs738409), GCKR (rs780094), TM6SF2 (rs58542926), and LYPLAL1 (rs12137855), have been investigated in relation to MAFLD susceptibility and progression. Genome-wide association studies and meta-analyses have revealed associations between these genetic variants and MAFLD risk, as well as their effects on lipid metabolism, glucose regulation, and liver function. Furthermore, emerging evidence suggests a possible connection between these MAFLD-associated polymorphisms and the severity of COVID-19. Studies exploring the association between indicated genetic variants and COVID-19 outcomes have shown conflicting results. Some studies observed a potential protective effect of certain variants against severe COVID-19, while others reported no significant associations. This review highlights the importance of understanding the genetic determinants of MAFLD and its potential implications for COVID-19 outcomes. Further research is needed to elucidate the precise mechanisms linking these genetic variants to disease severity and to develop gene profiling tools for the early prediction of COVID-19 outcomes. If confirmed as determinants of disease severity, these genetic polymorphisms could aid in the identification of high-risk individuals and in improving the management of COVID-19. |
| first_indexed | 2024-03-10T23:31:10Z |
| format | Article |
| id | doaj.art-e59d42abb7d74520b0c1d0128da2badc |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T23:31:10Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-e59d42abb7d74520b0c1d0128da2badc2023-11-19T03:20:55ZengMDPI AGViruses1999-49152023-08-01158172410.3390/v15081724Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive AnalysisMykhailo Buchynskyi0Valentyn Oksenych1Iryna Kamyshna2Sandor G. Vari3Aleksandr Kamyshnyi4Department of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, UkraineBroegelmann Research Laboratory, Department of Clinical Science, University of Bergen, 5020 Bergen, NorwayDepartment of Medical Rehabilitation, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, UkraineInternational Research and Innovation in Medicine Program, Cedars–Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Microbiology, Virology, and Immunology, I. Horbachevsky Ternopil National Medical University, 46001 Ternopil, UkraineMetabolic-associated fatty liver disease (MAFLD) and its potential impact on the severity of COVID-19 have gained significant attention during the pandemic. This review aimed to explore the genetic determinants associated with MAFLD, previously recognized as non-alcoholic fatty liver disease (NAFLD), and their potential influence on COVID-19 outcomes. Various genetic polymorphisms, including PNPLA3 (rs738409), GCKR (rs780094), TM6SF2 (rs58542926), and LYPLAL1 (rs12137855), have been investigated in relation to MAFLD susceptibility and progression. Genome-wide association studies and meta-analyses have revealed associations between these genetic variants and MAFLD risk, as well as their effects on lipid metabolism, glucose regulation, and liver function. Furthermore, emerging evidence suggests a possible connection between these MAFLD-associated polymorphisms and the severity of COVID-19. Studies exploring the association between indicated genetic variants and COVID-19 outcomes have shown conflicting results. Some studies observed a potential protective effect of certain variants against severe COVID-19, while others reported no significant associations. This review highlights the importance of understanding the genetic determinants of MAFLD and its potential implications for COVID-19 outcomes. Further research is needed to elucidate the precise mechanisms linking these genetic variants to disease severity and to develop gene profiling tools for the early prediction of COVID-19 outcomes. If confirmed as determinants of disease severity, these genetic polymorphisms could aid in the identification of high-risk individuals and in improving the management of COVID-19.https://www.mdpi.com/1999-4915/15/8/1724MAFLDCOVID-19NAFLDSARS-CoV-2PNPLArs738409 |
| spellingShingle | Mykhailo Buchynskyi Valentyn Oksenych Iryna Kamyshna Sandor G. Vari Aleksandr Kamyshnyi Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis Viruses MAFLD COVID-19 NAFLD SARS-CoV-2 PNPLA rs738409 |
| title | Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis |
| title_full | Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis |
| title_fullStr | Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis |
| title_full_unstemmed | Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis |
| title_short | Genetic Predictors of Comorbid Course of COVID-19 and MAFLD: A Comprehensive Analysis |
| title_sort | genetic predictors of comorbid course of covid 19 and mafld a comprehensive analysis |
| topic | MAFLD COVID-19 NAFLD SARS-CoV-2 PNPLA rs738409 |
| url | https://www.mdpi.com/1999-4915/15/8/1724 |
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