Effects of Hydrophobic Modifications on the Solution Self-Assembly of P(DMAEMA-co-QDMAEMA)-<i>b</i>-POEGMA Random Diblock Copolymers
In this work, the synthesis and the aqueous solution self-assembly behavior of novel partially hydrophobically modified poly(2-(dimethylamino) ethyl methacrylate)-b-poly(oligo(ethylelene glycol) methyl ether methacrylatetabel) pH and temperature responsive random diblock copolymers (P(DMAEMA-co-Q<...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/3/338 |
| _version_ | 1797408680871723008 |
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| author | Martha Kafetzi Stergios Pispas |
| author_facet | Martha Kafetzi Stergios Pispas |
| author_sort | Martha Kafetzi |
| collection | DOAJ |
| description | In this work, the synthesis and the aqueous solution self-assembly behavior of novel partially hydrophobically modified poly(2-(dimethylamino) ethyl methacrylate)-b-poly(oligo(ethylelene glycol) methyl ether methacrylatetabel) pH and temperature responsive random diblock copolymers (P(DMAEMA-co-Q<sub>6/12</sub>DMAEMA)-<i>b</i>-POEGMA), are reported. The chemical modifications were accomplished via quaternization with 1-iodohexane (Q<sub>6</sub>) and 1-iodododecane (Q<sub>12</sub>) and confirmed by <sup>1</sup>H-NMR spectroscopy. The successful synthesis of PDMAEMA-<i>b</i>-POEGMA precursor block copolymers was conducted by RAFT polymerization. The partial chemical modification of the diblocks resulted in the permanent attachment of long alkyl chains on the amine groups of the PDMAEMA block and the presence of tertiary and quaternary amines randomly distributed within the PDMAEMA block. Light scattering techniques confirmed that the increased hydrophobic character results in the formation of nanoaggregates of high mass and tunable pH and temperature response. The characteristics of the aggregates are also affected by the aqueous solution preparation protocol, the nature of the quaternizing agent and the quaternization degree. The incorporation of long alkyl chains allowed the encapsulation of indomethacin within the amphiphilic diblock copolymer aggregates. Nanostructures of increased size were detected due to the encapsulation of indomethacin into the interior of the hydrophobic domains. Drug release studies demonstrated that almost 50% of the encapsulated drug can be released on demand by aid of ultrasonication. |
| first_indexed | 2024-03-09T04:01:59Z |
| format | Article |
| id | doaj.art-e59e2d7142d54b6282a1bc0a82623942 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-09T04:01:59Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-e59e2d7142d54b6282a1bc0a826239422023-12-03T14:12:16ZengMDPI AGPolymers2073-43602021-01-0113333810.3390/polym13030338Effects of Hydrophobic Modifications on the Solution Self-Assembly of P(DMAEMA-co-QDMAEMA)-<i>b</i>-POEGMA Random Diblock CopolymersMartha Kafetzi0Stergios Pispas1Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, GreeceTheoretical and Physical Chemistry Institute, National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, 11635 Athens, GreeceIn this work, the synthesis and the aqueous solution self-assembly behavior of novel partially hydrophobically modified poly(2-(dimethylamino) ethyl methacrylate)-b-poly(oligo(ethylelene glycol) methyl ether methacrylatetabel) pH and temperature responsive random diblock copolymers (P(DMAEMA-co-Q<sub>6/12</sub>DMAEMA)-<i>b</i>-POEGMA), are reported. The chemical modifications were accomplished via quaternization with 1-iodohexane (Q<sub>6</sub>) and 1-iodododecane (Q<sub>12</sub>) and confirmed by <sup>1</sup>H-NMR spectroscopy. The successful synthesis of PDMAEMA-<i>b</i>-POEGMA precursor block copolymers was conducted by RAFT polymerization. The partial chemical modification of the diblocks resulted in the permanent attachment of long alkyl chains on the amine groups of the PDMAEMA block and the presence of tertiary and quaternary amines randomly distributed within the PDMAEMA block. Light scattering techniques confirmed that the increased hydrophobic character results in the formation of nanoaggregates of high mass and tunable pH and temperature response. The characteristics of the aggregates are also affected by the aqueous solution preparation protocol, the nature of the quaternizing agent and the quaternization degree. The incorporation of long alkyl chains allowed the encapsulation of indomethacin within the amphiphilic diblock copolymer aggregates. Nanostructures of increased size were detected due to the encapsulation of indomethacin into the interior of the hydrophobic domains. Drug release studies demonstrated that almost 50% of the encapsulated drug can be released on demand by aid of ultrasonication.https://www.mdpi.com/2073-4360/13/3/338amphiphilic block copolymersrandom blocksRAFT polymerizationquaternizationhydrophobic modificationsolution properties |
| spellingShingle | Martha Kafetzi Stergios Pispas Effects of Hydrophobic Modifications on the Solution Self-Assembly of P(DMAEMA-co-QDMAEMA)-<i>b</i>-POEGMA Random Diblock Copolymers Polymers amphiphilic block copolymers random blocks RAFT polymerization quaternization hydrophobic modification solution properties |
| title | Effects of Hydrophobic Modifications on the Solution Self-Assembly of P(DMAEMA-co-QDMAEMA)-<i>b</i>-POEGMA Random Diblock Copolymers |
| title_full | Effects of Hydrophobic Modifications on the Solution Self-Assembly of P(DMAEMA-co-QDMAEMA)-<i>b</i>-POEGMA Random Diblock Copolymers |
| title_fullStr | Effects of Hydrophobic Modifications on the Solution Self-Assembly of P(DMAEMA-co-QDMAEMA)-<i>b</i>-POEGMA Random Diblock Copolymers |
| title_full_unstemmed | Effects of Hydrophobic Modifications on the Solution Self-Assembly of P(DMAEMA-co-QDMAEMA)-<i>b</i>-POEGMA Random Diblock Copolymers |
| title_short | Effects of Hydrophobic Modifications on the Solution Self-Assembly of P(DMAEMA-co-QDMAEMA)-<i>b</i>-POEGMA Random Diblock Copolymers |
| title_sort | effects of hydrophobic modifications on the solution self assembly of p dmaema co qdmaema i b i poegma random diblock copolymers |
| topic | amphiphilic block copolymers random blocks RAFT polymerization quaternization hydrophobic modification solution properties |
| url | https://www.mdpi.com/2073-4360/13/3/338 |
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