Hepatitis C Virus Infection Induces Hepatic Expression of NF-κB-Inducing Kinase and Lipogenesis by Downregulating miR-122

Hepatitis C Virus Infection Induces Hepatic Expression of NF-κB-Inducing Kinase and Lipogenesis by Downregulating miR-122

ABSTRACT Hepatitis C virus (HCV) harnesses host dependencies to infect human hepatocytes. We previously identified a pivotal role of IκB kinase α (IKK-α) in regulating cellular lipogenesis and HCV assembly. In this study, we defined and characterized NF-κB-inducing kinase (NIK) as an IKK-α upstream...

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Bibliographic Details
Main Authors: Brianna Lowey, Laura Hertz, Stephan Chiu, Kristin Valdez, Qisheng Li, T. Jake Liang
Format: Article
Language:English
Published: American Society for Microbiology 2019-08-01
Series:mBio
Subjects:
cell signaling
hepatic inflammation
lipid synthesis
microRNA
viral pathogenesis
Online Access:https://journals.asm.org/doi/10.1128/mBio.01617-19

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