The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy
Food allergy (FA) is a growing public health concern, with an increasing prevalence in Western countries. Increasing evidence suggests that the balance of human gut microbiota and the integrity of our intestinal barrier may play roles in the development of FA. Environmental factors, including indust...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/1/92 |
| _version_ | 1797358359067754496 |
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| author | Remo Poto William Fusco Emanuele Rinninella Marco Cintoni Francesco Kaitsas Pauline Raoul Cristiano Caruso Maria Cristina Mele Gilda Varricchi Antonio Gasbarrini Giovanni Cammarota Gianluca Ianiro |
| author_facet | Remo Poto William Fusco Emanuele Rinninella Marco Cintoni Francesco Kaitsas Pauline Raoul Cristiano Caruso Maria Cristina Mele Gilda Varricchi Antonio Gasbarrini Giovanni Cammarota Gianluca Ianiro |
| author_sort | Remo Poto |
| collection | DOAJ |
| description | Food allergy (FA) is a growing public health concern, with an increasing prevalence in Western countries. Increasing evidence suggests that the balance of human gut microbiota and the integrity of our intestinal barrier may play roles in the development of FA. Environmental factors, including industrialization and consumption of highly processed food, can contribute to altering the gut microbiota and the intestinal barrier, increasing the susceptibility to allergic sensitization. Compositional and functional alterations to the gut microbiome have also been associated with FA. In addition, increased permeability of the gut barrier allows the translocation of allergenic molecules, triggering Th2 immune responses. Preclinical and clinical studies have highlighted the potential of probiotics, prebiotics, and postbiotics in the prevention and treatment of FA through enhancing gut barrier function and promoting the restoration of healthy gut microbiota. Finally, fecal microbiota transplantation (FMT) is now being explored as a promising therapeutic strategy to prevent FA in both experimental and clinical studies. In this review article, we aim to explore the complex interplay between intestinal permeability and gut microbiota in the development of FA, as well as depict potential therapeutic strategies. |
| first_indexed | 2024-03-08T15:00:47Z |
| format | Article |
| id | doaj.art-e59f53743133456a84e288e24256463d |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T15:00:47Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e59f53743133456a84e288e24256463d2024-01-10T15:05:30ZengMDPI AGNutrients2072-66432023-12-011619210.3390/nu16010092The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food AllergyRemo Poto0William Fusco1Emanuele Rinninella2Marco Cintoni3Francesco Kaitsas4Pauline Raoul5Cristiano Caruso6Maria Cristina Mele7Gilda Varricchi8Antonio Gasbarrini9Giovanni Cammarota10Gianluca Ianiro11Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyFood allergy (FA) is a growing public health concern, with an increasing prevalence in Western countries. Increasing evidence suggests that the balance of human gut microbiota and the integrity of our intestinal barrier may play roles in the development of FA. Environmental factors, including industrialization and consumption of highly processed food, can contribute to altering the gut microbiota and the intestinal barrier, increasing the susceptibility to allergic sensitization. Compositional and functional alterations to the gut microbiome have also been associated with FA. In addition, increased permeability of the gut barrier allows the translocation of allergenic molecules, triggering Th2 immune responses. Preclinical and clinical studies have highlighted the potential of probiotics, prebiotics, and postbiotics in the prevention and treatment of FA through enhancing gut barrier function and promoting the restoration of healthy gut microbiota. Finally, fecal microbiota transplantation (FMT) is now being explored as a promising therapeutic strategy to prevent FA in both experimental and clinical studies. In this review article, we aim to explore the complex interplay between intestinal permeability and gut microbiota in the development of FA, as well as depict potential therapeutic strategies.https://www.mdpi.com/2072-6643/16/1/92food allergyintestinal barrierleaky gutgut microbiotaprebioticsprobiotics |
| spellingShingle | Remo Poto William Fusco Emanuele Rinninella Marco Cintoni Francesco Kaitsas Pauline Raoul Cristiano Caruso Maria Cristina Mele Gilda Varricchi Antonio Gasbarrini Giovanni Cammarota Gianluca Ianiro The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy Nutrients food allergy intestinal barrier leaky gut gut microbiota prebiotics probiotics |
| title | The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy |
| title_full | The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy |
| title_fullStr | The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy |
| title_full_unstemmed | The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy |
| title_short | The Role of Gut Microbiota and Leaky Gut in the Pathogenesis of Food Allergy |
| title_sort | role of gut microbiota and leaky gut in the pathogenesis of food allergy |
| topic | food allergy intestinal barrier leaky gut gut microbiota prebiotics probiotics |
| url | https://www.mdpi.com/2072-6643/16/1/92 |
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