Diagnosis, classification and treatment of gestational trophoblastic neoplasia
Gestational trophoblastic neoplasia (GTN) is the term to describe a set of malignant placental diseases, including invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Both invasive mole and choriocarcinoma respond well to chemotherapy, and cure rat...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia
2015-01-01
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| Series: | Revista Brasileira de Ginecologia e Obstetrícia |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032015000100042&tlng=en |
| _version_ | 1798021258481238016 |
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| author | Andressa Biscaro Antônio Braga Ross Stuart Berkowitz |
| author_facet | Andressa Biscaro Antônio Braga Ross Stuart Berkowitz |
| author_sort | Andressa Biscaro |
| collection | DOAJ |
| description | Gestational trophoblastic neoplasia (GTN) is the term to describe a set of malignant placental diseases, including invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Both invasive mole and choriocarcinoma respond well to chemotherapy, and cure rates are greater than 90%. Since the advent of chemotherapy, low-risk GTN has been treated with a single agent, usually methotrexate or actinomycin D. Cases of high-risk GTN, however, should be treated with multiagent chemotherapy, and the regimen usually selected is EMA-CO, which combines etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine. This study reviews the literature about GTN to discuss current knowledge about its diagnosis and treatment. |
| first_indexed | 2024-04-11T17:12:00Z |
| format | Article |
| id | doaj.art-e59fbf0307764e20b8d386515e56cdfb |
| institution | Directory Open Access Journal |
| issn | 0100-7203 |
| language | English |
| last_indexed | 2024-04-11T17:12:00Z |
| publishDate | 2015-01-01 |
| publisher | Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
| record_format | Article |
| series | Revista Brasileira de Ginecologia e Obstetrícia |
| spelling | doaj.art-e59fbf0307764e20b8d386515e56cdfb2022-12-22T04:12:54ZengFederação Brasileira das Sociedades de Ginecologia e ObstetríciaRevista Brasileira de Ginecologia e Obstetrícia0100-72032015-01-01371425110.1590/SO100-720320140005198Diagnosis, classification and treatment of gestational trophoblastic neoplasiaAndressa BiscaroAntônio BragaRoss Stuart BerkowitzGestational trophoblastic neoplasia (GTN) is the term to describe a set of malignant placental diseases, including invasive mole, choriocarcinoma, placental site trophoblastic tumor and epithelioid trophoblastic tumor. Both invasive mole and choriocarcinoma respond well to chemotherapy, and cure rates are greater than 90%. Since the advent of chemotherapy, low-risk GTN has been treated with a single agent, usually methotrexate or actinomycin D. Cases of high-risk GTN, however, should be treated with multiagent chemotherapy, and the regimen usually selected is EMA-CO, which combines etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine. This study reviews the literature about GTN to discuss current knowledge about its diagnosis and treatment.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032015000100042&tlng=en |
| spellingShingle | Andressa Biscaro Antônio Braga Ross Stuart Berkowitz Diagnosis, classification and treatment of gestational trophoblastic neoplasia Revista Brasileira de Ginecologia e Obstetrícia |
| title | Diagnosis, classification and treatment of gestational trophoblastic neoplasia |
| title_full | Diagnosis, classification and treatment of gestational trophoblastic neoplasia |
| title_fullStr | Diagnosis, classification and treatment of gestational trophoblastic neoplasia |
| title_full_unstemmed | Diagnosis, classification and treatment of gestational trophoblastic neoplasia |
| title_short | Diagnosis, classification and treatment of gestational trophoblastic neoplasia |
| title_sort | diagnosis classification and treatment of gestational trophoblastic neoplasia |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032015000100042&tlng=en |
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