Comparative assessment of effect of malt with different bud length on prolactin in hyperprolactinemia rat
Malt is the mature fruit of Hordeum vulgare L. after germination and drying and has been applied for treatment female abnormal galactorrhea. Previous studies have showed total alkaloids in malt have anti-HPRL effect. However, total alkaloids of malt change with the growth cycle, and the specified le...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2021-11-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502021000100536&tlng=en |
| _version_ | 1818367780605394944 |
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| author | Min Chen Mingyan Wang Yonggang Chen Jin He Jili Zou Junhua Meng Lin Zhao Jinhu Wu |
| author_facet | Min Chen Mingyan Wang Yonggang Chen Jin He Jili Zou Junhua Meng Lin Zhao Jinhu Wu |
| author_sort | Min Chen |
| collection | DOAJ |
| description | Malt is the mature fruit of Hordeum vulgare L. after germination and drying and has been applied for treatment female abnormal galactorrhea. Previous studies have showed total alkaloids in malt have anti-HPRL effect. However, total alkaloids of malt change with the growth cycle, and the specified levels of total alkaloids in different bud length of malt have not been decided. To determine the definitive level of total alkaloids in different buds of malt and the most suitable bud length for clinical application by comparing effects on hyperprolactinemia rat. During the budding of malt, the content of total alkaloids first increased and then decreased, and it peaked at a bud length of 0.75 cm. Treated the HPRL model rats with different buds of malt, the PRL level was decreased, the number of PRLpositive cells and the mRNA expression level in the pituitary were significantly declined, and the number of dopamine D1 and D2 receptors in the hypothalamus was increased. The above changes were most significant in 0.75 cm bud. These results suggest that in terms of the content of effective substance and the effects on HPRL model rats, a malt bud length of 0.75 cm is optimal for clinical application. |
| first_indexed | 2024-12-13T22:57:30Z |
| format | Article |
| id | doaj.art-e5a014d261cc41b28577ec3b354c7b81 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-13T22:57:30Z |
| publishDate | 2021-11-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-e5a014d261cc41b28577ec3b354c7b812022-12-21T23:28:29ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902021-11-015710.1590/s2175-979020200004181104Comparative assessment of effect of malt with different bud length on prolactin in hyperprolactinemia ratMin ChenMingyan WangYonggang Chenhttps://orcid.org/0000-0002-7861-7831Jin HeJili ZouJunhua MengLin ZhaoJinhu WuMalt is the mature fruit of Hordeum vulgare L. after germination and drying and has been applied for treatment female abnormal galactorrhea. Previous studies have showed total alkaloids in malt have anti-HPRL effect. However, total alkaloids of malt change with the growth cycle, and the specified levels of total alkaloids in different bud length of malt have not been decided. To determine the definitive level of total alkaloids in different buds of malt and the most suitable bud length for clinical application by comparing effects on hyperprolactinemia rat. During the budding of malt, the content of total alkaloids first increased and then decreased, and it peaked at a bud length of 0.75 cm. Treated the HPRL model rats with different buds of malt, the PRL level was decreased, the number of PRLpositive cells and the mRNA expression level in the pituitary were significantly declined, and the number of dopamine D1 and D2 receptors in the hypothalamus was increased. The above changes were most significant in 0.75 cm bud. These results suggest that in terms of the content of effective substance and the effects on HPRL model rats, a malt bud length of 0.75 cm is optimal for clinical application.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502021000100536&tlng=enMaltAlkaloidEndocrine systemHormoneDopamine receptors |
| spellingShingle | Min Chen Mingyan Wang Yonggang Chen Jin He Jili Zou Junhua Meng Lin Zhao Jinhu Wu Comparative assessment of effect of malt with different bud length on prolactin in hyperprolactinemia rat Brazilian Journal of Pharmaceutical Sciences Malt Alkaloid Endocrine system Hormone Dopamine receptors |
| title | Comparative assessment of effect of malt with different bud length on prolactin in hyperprolactinemia rat |
| title_full | Comparative assessment of effect of malt with different bud length on prolactin in hyperprolactinemia rat |
| title_fullStr | Comparative assessment of effect of malt with different bud length on prolactin in hyperprolactinemia rat |
| title_full_unstemmed | Comparative assessment of effect of malt with different bud length on prolactin in hyperprolactinemia rat |
| title_short | Comparative assessment of effect of malt with different bud length on prolactin in hyperprolactinemia rat |
| title_sort | comparative assessment of effect of malt with different bud length on prolactin in hyperprolactinemia rat |
| topic | Malt Alkaloid Endocrine system Hormone Dopamine receptors |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502021000100536&tlng=en |
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