Cerebrospinal Fluid Metabolomics: Pilot Study of Using Metabolomics to Assess Diet and Metabolic Interventions in Alzheimer’s Disease and Mild Cognitive Impairment

Cerebrospinal Fluid Metabolomics: Pilot Study of Using Metabolomics to Assess Diet and Metabolic Interventions in Alzheimer’s Disease and Mild Cognitive Impairment

Brain glucose hypometabolism is an early sign of Alzheimer’s disease (AD), and interventions which offset this deficit, such as ketogenic diets, show promise as AD therapeutics. Conversely, high-fat feeding may exacerbate AD risk. We analyzed the metabolomic profile of cerebrospinal fluid (CSF) in a...

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Bibliographic Details
Main Authors: Angela J. Hanson, William A. Banks, Lisa F. Bettcher, Robert Pepin, Daniel Raftery, Sandi L. Navarro, Suzanne Craft
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Metabolites
Subjects:
metabolomics
ketone bodies
cerebrospinal fluid
Alzheimer’s
blood brain barrier
Online Access:https://www.mdpi.com/2218-1989/13/4/569

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