Analysis of ADORA2A rs5760423 and CYP1A2 rs762551 Genetic Variants in Patients with Alzheimer’s Disease
Various studies have been conducted, exploring the genetic susceptibility of Alzheimer’s disease (AD). Adenosine receptor subtype A2a (ADORA2A) and cytochrome P450 1A2 (CYP1A2) are implicated in pathways such as oxidative stress and caffeine metabolism, which are associated with AD. The aim of this...
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/14400 |
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| author | Vasileios Siokas Dimitra S. Mouliou Ioannis Liampas Athina-Maria Aloizou Vasiliki Folia Elli Zoupa Anastasios Papadimitriou Eleftherios Lavdas Dimitrios P. Bogdanos Efthimios Dardiotis |
| author_facet | Vasileios Siokas Dimitra S. Mouliou Ioannis Liampas Athina-Maria Aloizou Vasiliki Folia Elli Zoupa Anastasios Papadimitriou Eleftherios Lavdas Dimitrios P. Bogdanos Efthimios Dardiotis |
| author_sort | Vasileios Siokas |
| collection | DOAJ |
| description | Various studies have been conducted, exploring the genetic susceptibility of Alzheimer’s disease (AD). Adenosine receptor subtype A2a (ADORA2A) and cytochrome P450 1A2 (CYP1A2) are implicated in pathways such as oxidative stress and caffeine metabolism, which are associated with AD. The aim of this study was to explore for any potential association between the ADORA2A rs5760423 and the CYP1A2 rs762551 genetic variants and AD. A case–control study was performed with a total of 654 subjects (327 healthy controls and 327 patients with AD). Five genetic models were assumed. We also examined the allele–allele combination of both variants. The value of 0.05 was considered as the statistical significance threshold. A statistically significant association was found between ADORA2A rs5760423 and AD, as the “T” allele was associated with increased AD risk in recessive (OR = 1.51 (1.03–2.21)) and log-additive (OR = 1.30 (1.04–1.62)) genetic modes. In the codominant model, the TT genotype was more prevalent compared to the GG genotype (OR = 1.71 (1.09–2.66)). The statistical significance was maintained after adjustment for sex. No association between CYP1A2 rs762551 or allele–allele combination and AD was detected. We provide preliminary indication for a possible association between the ADORA2A rs5760423 genetic polymorphism and AD. |
| first_indexed | 2024-03-09T18:16:10Z |
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| id | doaj.art-e5a9b2e20b06407997ae17dccc0a04be |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:16:10Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e5a9b2e20b06407997ae17dccc0a04be2023-11-24T08:43:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221440010.3390/ijms232214400Analysis of ADORA2A rs5760423 and CYP1A2 rs762551 Genetic Variants in Patients with Alzheimer’s DiseaseVasileios Siokas0Dimitra S. Mouliou1Ioannis Liampas2Athina-Maria Aloizou3Vasiliki Folia4Elli Zoupa5Anastasios Papadimitriou6Eleftherios Lavdas7Dimitrios P. Bogdanos8Efthimios Dardiotis9Laboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceLab of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceLarisa Day Care Center of People with Alzheimer’s Disease, Association for Regional Development and Mental Health (EPAPSY), 15124 Marousi, GreeceGeneral Hospital of Lamia, 35100 Lamia, GreeceDepartment of Biomedical Sciences, University of West Attica, 12243 Athens, GreeceDepartment of Rheumatology and Clinical Immunology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, GreeceVarious studies have been conducted, exploring the genetic susceptibility of Alzheimer’s disease (AD). Adenosine receptor subtype A2a (ADORA2A) and cytochrome P450 1A2 (CYP1A2) are implicated in pathways such as oxidative stress and caffeine metabolism, which are associated with AD. The aim of this study was to explore for any potential association between the ADORA2A rs5760423 and the CYP1A2 rs762551 genetic variants and AD. A case–control study was performed with a total of 654 subjects (327 healthy controls and 327 patients with AD). Five genetic models were assumed. We also examined the allele–allele combination of both variants. The value of 0.05 was considered as the statistical significance threshold. A statistically significant association was found between ADORA2A rs5760423 and AD, as the “T” allele was associated with increased AD risk in recessive (OR = 1.51 (1.03–2.21)) and log-additive (OR = 1.30 (1.04–1.62)) genetic modes. In the codominant model, the TT genotype was more prevalent compared to the GG genotype (OR = 1.71 (1.09–2.66)). The statistical significance was maintained after adjustment for sex. No association between CYP1A2 rs762551 or allele–allele combination and AD was detected. We provide preliminary indication for a possible association between the ADORA2A rs5760423 genetic polymorphism and AD.https://www.mdpi.com/1422-0067/23/22/14400Alzheimer’s diseasecaffeine metabolismoxidative stresspolymorphismgeneticsADORA2A rs5760423 |
| spellingShingle | Vasileios Siokas Dimitra S. Mouliou Ioannis Liampas Athina-Maria Aloizou Vasiliki Folia Elli Zoupa Anastasios Papadimitriou Eleftherios Lavdas Dimitrios P. Bogdanos Efthimios Dardiotis Analysis of ADORA2A rs5760423 and CYP1A2 rs762551 Genetic Variants in Patients with Alzheimer’s Disease International Journal of Molecular Sciences Alzheimer’s disease caffeine metabolism oxidative stress polymorphism genetics ADORA2A rs5760423 |
| title | Analysis of ADORA2A rs5760423 and CYP1A2 rs762551 Genetic Variants in Patients with Alzheimer’s Disease |
| title_full | Analysis of ADORA2A rs5760423 and CYP1A2 rs762551 Genetic Variants in Patients with Alzheimer’s Disease |
| title_fullStr | Analysis of ADORA2A rs5760423 and CYP1A2 rs762551 Genetic Variants in Patients with Alzheimer’s Disease |
| title_full_unstemmed | Analysis of ADORA2A rs5760423 and CYP1A2 rs762551 Genetic Variants in Patients with Alzheimer’s Disease |
| title_short | Analysis of ADORA2A rs5760423 and CYP1A2 rs762551 Genetic Variants in Patients with Alzheimer’s Disease |
| title_sort | analysis of adora2a rs5760423 and cyp1a2 rs762551 genetic variants in patients with alzheimer s disease |
| topic | Alzheimer’s disease caffeine metabolism oxidative stress polymorphism genetics ADORA2A rs5760423 |
| url | https://www.mdpi.com/1422-0067/23/22/14400 |
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