Protocol for a randomized controlled trial on community education and surveillance on antibiotics use among young children in Nepal
Background: Antimicrobial resistance (AMR) is one of the top ten threats to global health. There exists limited empirical evidence on effective approaches to address this threat. In low- and middle-income countries (LMICs), one of the primary drivers of AMR is easy access to antibiotics without pres...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-08-01
|
| Series: | Contemporary Clinical Trials Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451865423001230 |
| _version_ | 1797781889618018304 |
|---|---|
| author | Prajwol Nepal Anup Subedee Henish Shakya Sanjaya Poudel Supriya Joshi Kshitij Karki Deepak Bajracharya Tyler Prentiss Linda Kaljee Yubraj Acharya |
| author_facet | Prajwol Nepal Anup Subedee Henish Shakya Sanjaya Poudel Supriya Joshi Kshitij Karki Deepak Bajracharya Tyler Prentiss Linda Kaljee Yubraj Acharya |
| author_sort | Prajwol Nepal |
| collection | DOAJ |
| description | Background: Antimicrobial resistance (AMR) is one of the top ten threats to global health. There exists limited empirical evidence on effective approaches to address this threat. In low- and middle-income countries (LMICs), one of the primary drivers of AMR is easy access to antibiotics without prescriptions, in particular from community pharmacies. Interventions to reduce non-prescribed use of antibiotics and surveillance systems to track such usage are critically needed. This protocol describes a study that aims to test the effect of an educational intervention targeted to parents of young children on non-prescribed antibiotics consumption in Nepal and to track such consumption using a phone-based application. Methods: The study is a clustered randomized controlled trial, in which we randomly assign 40 urban wards of Kathmandu Valley to either treatment group or control group, and randomly select 24 households in each ward. Households in the treatment group will receive an education intervention consisting of an “AMR pitch” (an in-person interaction that lasts up to an hour) by community nurses, videos and text messages on AMR every two weeks, and a brochure. We will conduct a survey at baseline with the parents of children ages 6 months to 10 years and track consumption of antibiotics and health care use among these children for a period of 6 months using a phone-based application. Conclusion: While the study will primarily inform future policy and programmatic efforts to reduce AMR in Nepal, the study—both the education intervention and the surveillance system—can serve as a prototype for tackling AMR in other similar settings. |
| first_indexed | 2024-03-13T00:03:16Z |
| format | Article |
| id | doaj.art-e5aaaf2a01a04b04838286e0bf467c75 |
| institution | Directory Open Access Journal |
| issn | 2451-8654 |
| language | English |
| last_indexed | 2024-03-13T00:03:16Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Contemporary Clinical Trials Communications |
| spelling | doaj.art-e5aaaf2a01a04b04838286e0bf467c752023-07-13T05:30:38ZengElsevierContemporary Clinical Trials Communications2451-86542023-08-0134101177Protocol for a randomized controlled trial on community education and surveillance on antibiotics use among young children in NepalPrajwol Nepal0Anup Subedee1Henish Shakya2Sanjaya Poudel3Supriya Joshi4Kshitij Karki5Deepak Bajracharya6Tyler Prentiss7Linda Kaljee8Yubraj Acharya9University of North Carolina-Chapel Hill, Chapel Hill, USAPublic Health Concern Trust, Nepal & Kirtipur Hospital, NepalKIST Medical College Hospital, Kathmandu, NepalSunyaEk, Kathmandu, NepalThe Pennsylvania State University, University Park, USAGroup for Technical Assistance (G.T.A.) Foundation, Kathmandu, NepalGroup for Technical Assistance (G.T.A.) Foundation, Kathmandu, NepalGlobal Health Initiative, Henry Ford Health, Detroit, USAGlobal Health Initiative, Henry Ford Health, Detroit, USAThe Pennsylvania State University, University Park, USA; Corresponding author. Department of Health Policy & Administration, 601L Ford Building, University Park, PA, 16802, USA.Background: Antimicrobial resistance (AMR) is one of the top ten threats to global health. There exists limited empirical evidence on effective approaches to address this threat. In low- and middle-income countries (LMICs), one of the primary drivers of AMR is easy access to antibiotics without prescriptions, in particular from community pharmacies. Interventions to reduce non-prescribed use of antibiotics and surveillance systems to track such usage are critically needed. This protocol describes a study that aims to test the effect of an educational intervention targeted to parents of young children on non-prescribed antibiotics consumption in Nepal and to track such consumption using a phone-based application. Methods: The study is a clustered randomized controlled trial, in which we randomly assign 40 urban wards of Kathmandu Valley to either treatment group or control group, and randomly select 24 households in each ward. Households in the treatment group will receive an education intervention consisting of an “AMR pitch” (an in-person interaction that lasts up to an hour) by community nurses, videos and text messages on AMR every two weeks, and a brochure. We will conduct a survey at baseline with the parents of children ages 6 months to 10 years and track consumption of antibiotics and health care use among these children for a period of 6 months using a phone-based application. Conclusion: While the study will primarily inform future policy and programmatic efforts to reduce AMR in Nepal, the study—both the education intervention and the surveillance system—can serve as a prototype for tackling AMR in other similar settings.http://www.sciencedirect.com/science/article/pii/S2451865423001230Antimicrobial resistanceRandomized controlled trialsNepal |
| spellingShingle | Prajwol Nepal Anup Subedee Henish Shakya Sanjaya Poudel Supriya Joshi Kshitij Karki Deepak Bajracharya Tyler Prentiss Linda Kaljee Yubraj Acharya Protocol for a randomized controlled trial on community education and surveillance on antibiotics use among young children in Nepal Contemporary Clinical Trials Communications Antimicrobial resistance Randomized controlled trials Nepal |
| title | Protocol for a randomized controlled trial on community education and surveillance on antibiotics use among young children in Nepal |
| title_full | Protocol for a randomized controlled trial on community education and surveillance on antibiotics use among young children in Nepal |
| title_fullStr | Protocol for a randomized controlled trial on community education and surveillance on antibiotics use among young children in Nepal |
| title_full_unstemmed | Protocol for a randomized controlled trial on community education and surveillance on antibiotics use among young children in Nepal |
| title_short | Protocol for a randomized controlled trial on community education and surveillance on antibiotics use among young children in Nepal |
| title_sort | protocol for a randomized controlled trial on community education and surveillance on antibiotics use among young children in nepal |
| topic | Antimicrobial resistance Randomized controlled trials Nepal |
| url | http://www.sciencedirect.com/science/article/pii/S2451865423001230 |
| work_keys_str_mv | AT prajwolnepal protocolforarandomizedcontrolledtrialoncommunityeducationandsurveillanceonantibioticsuseamongyoungchildreninnepal AT anupsubedee protocolforarandomizedcontrolledtrialoncommunityeducationandsurveillanceonantibioticsuseamongyoungchildreninnepal AT henishshakya protocolforarandomizedcontrolledtrialoncommunityeducationandsurveillanceonantibioticsuseamongyoungchildreninnepal AT sanjayapoudel protocolforarandomizedcontrolledtrialoncommunityeducationandsurveillanceonantibioticsuseamongyoungchildreninnepal AT supriyajoshi protocolforarandomizedcontrolledtrialoncommunityeducationandsurveillanceonantibioticsuseamongyoungchildreninnepal AT kshitijkarki protocolforarandomizedcontrolledtrialoncommunityeducationandsurveillanceonantibioticsuseamongyoungchildreninnepal AT deepakbajracharya protocolforarandomizedcontrolledtrialoncommunityeducationandsurveillanceonantibioticsuseamongyoungchildreninnepal AT tylerprentiss protocolforarandomizedcontrolledtrialoncommunityeducationandsurveillanceonantibioticsuseamongyoungchildreninnepal AT lindakaljee protocolforarandomizedcontrolledtrialoncommunityeducationandsurveillanceonantibioticsuseamongyoungchildreninnepal AT yubrajacharya protocolforarandomizedcontrolledtrialoncommunityeducationandsurveillanceonantibioticsuseamongyoungchildreninnepal |