Aberrant hydroxymethylation in promoter CpG regions of genes related to the cell cycle and apoptosis characterizes advanced chronic myeloid leukemia disease, poor imatinib respondents and poor survival

Aberrant hydroxymethylation in promoter CpG regions of genes related to the cell cycle and apoptosis characterizes advanced chronic myeloid leukemia disease, poor imatinib respondents and poor survival

Abstract Background There is strong evidence that disease progression, drug response and overall clinical outcomes of CML disease are not only decided by BCR/ABL1 oncoprotein but depend on accumulation of additional genetic and epigenetic aberrations. DNA hydroxymethylation is implicated in the deve...

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Bibliographic Details
Main Authors: Sameer Ahmad Guru, Mamta Pervin Sumi, Abdul Rashid Mir, Mirza Masroor Ali Beg, Bidhan Chandra koner, Alpana Saxena
Format: Article
Language:English
Published: BMC 2022-04-01
Series:BMC Cancer
Subjects:
Chronic Myeloid Leukaemia
Imatinib
Epigenetics
Promoter hypermethylation
Cell cycle and apoptosis related genes
Online Access:https://doi.org/10.1186/s12885-022-09481-9

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