Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2.
Recent clinical trials raised concerns regarding the cardiovascular toxicity of selective cyclooxygenase-2 (COX-2) inhibitors. Many active dietary factors are reported to suppress carcinogenesis by targeting COX-2. A major question was accordingly raised: why has the lifelong use of phytochemicals t...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3789677?pdf=render |
| _version_ | 1818330767132983296 |
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| author | Haitao Li Feng Zhu Yanwen Sun Bing Li Naomi Oi Hanyong Chen Ronald A Lubet Ann M Bode Zigang Dong |
| author_facet | Haitao Li Feng Zhu Yanwen Sun Bing Li Naomi Oi Hanyong Chen Ronald A Lubet Ann M Bode Zigang Dong |
| author_sort | Haitao Li |
| collection | DOAJ |
| description | Recent clinical trials raised concerns regarding the cardiovascular toxicity of selective cyclooxygenase-2 (COX-2) inhibitors. Many active dietary factors are reported to suppress carcinogenesis by targeting COX-2. A major question was accordingly raised: why has the lifelong use of phytochemicals that likely inhibit COX-2 presumably not been associated with adverse cardiovascular side effects. To answer this question, we selected a library of dietary-derived phytochemicals and evaluated their potential cardiovascular toxicity in human umbilical vein endothelial cells. Our data indicated that the possibility of cardiovascular toxicity of these dietary phytochemicals was low. Further mechanistic studies revealed that the actions of these phytochemicals were similar to aspirin in that they mainly inhibited COX-1 rather than COX-2, especially at low doses. |
| first_indexed | 2024-12-13T13:09:11Z |
| format | Article |
| id | doaj.art-e5ae3c7251064df2997bdbc8a1fa9fbe |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T13:09:11Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e5ae3c7251064df2997bdbc8a1fa9fbe2022-12-21T23:44:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7645210.1371/journal.pone.0076452Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2.Haitao LiFeng ZhuYanwen SunBing LiNaomi OiHanyong ChenRonald A LubetAnn M BodeZigang DongRecent clinical trials raised concerns regarding the cardiovascular toxicity of selective cyclooxygenase-2 (COX-2) inhibitors. Many active dietary factors are reported to suppress carcinogenesis by targeting COX-2. A major question was accordingly raised: why has the lifelong use of phytochemicals that likely inhibit COX-2 presumably not been associated with adverse cardiovascular side effects. To answer this question, we selected a library of dietary-derived phytochemicals and evaluated their potential cardiovascular toxicity in human umbilical vein endothelial cells. Our data indicated that the possibility of cardiovascular toxicity of these dietary phytochemicals was low. Further mechanistic studies revealed that the actions of these phytochemicals were similar to aspirin in that they mainly inhibited COX-1 rather than COX-2, especially at low doses.http://europepmc.org/articles/PMC3789677?pdf=render |
| spellingShingle | Haitao Li Feng Zhu Yanwen Sun Bing Li Naomi Oi Hanyong Chen Ronald A Lubet Ann M Bode Zigang Dong Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2. PLoS ONE |
| title | Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2. |
| title_full | Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2. |
| title_fullStr | Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2. |
| title_full_unstemmed | Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2. |
| title_short | Select dietary phytochemicals function as inhibitors of COX-1 but not COX-2. |
| title_sort | select dietary phytochemicals function as inhibitors of cox 1 but not cox 2 |
| url | http://europepmc.org/articles/PMC3789677?pdf=render |
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